Cadmium and polyvinyl chloride microplastics induce mitochondrial damage and apoptosis under oxidative stress in duck kidney DOI Creative Commons
Hui Zou, Song Jie, Xiang‐Qian Luo

et al.

Poultry Science, Journal Year: 2024, Volume and Issue: 104(1), P. 104490 - 104490

Published: Nov. 12, 2024

Polyvinyl chloride microplastics (PVC-MPs) and Cadmium (Cd) are widely occurring water pollutants that interact with each other to exert toxic effects. As a waterfowl, Muscovy duck is more susceptible PVC-MPs Cd than land poultry. In this study, was used as research model, 10 mg/L 50 mg/kg were alone in combine explore the effect on kidney of duck. We found treatment or changed weight, increased creatinine urea nitrogen content, disrupted oxidative balance macro/trace element metabolism, while combination PVC-MPs+Cd reduced accumulation kidney. addition, caused mitochondrial damage, increase decrease mitochondria-associated proteins (Fis1, Drp1, PGC-1α, Nrf1), Nrf2 signaling pathway plays key role detoxification alleviation stress, we recovered related (Nrf2, Keap-1, HO-1, NQO1, AC-SOD

Language: Английский

Mapping micro(nano)plastics in various organ systems: their emerging links to human diseases? DOI
Yating Luo,

Xiuya Xu,

Qin Yin

et al.

TrAC Trends in Analytical Chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 118114 - 118114

Published: Dec. 1, 2024

Language: Английский

Citations

2
Nanoelectrochemistry monitoring of intracellular reactive oxygen and nitrogen species induced by nanoplastic exposure DOI

Hui‐Qian Wu,

Yuting Qi,

Bing-Yi Guo

et al.

Chemical Communications, Journal Year: 2024, Volume and Issue: 60(42), P. 5546 - 5549

Published: Jan. 1, 2024

This work achieved the quantitative discrimination, dynamic monitoring and sources exploration of four main ROS/RNS (NO 2 − , NO, H O ONOO ) within individual alveolar epithelial cells treated by polystyrene nanoplastics using SiC@Pt nanowire electrodes.

Language: Английский

Citations

1
Degradation of floor finishing materials owing to continuous gait: A comprehensive study on the generation and impact of microplastics DOI

Won Duk Suh,

Ho Hyeon Jo, Young Uk Kim

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 484, P. 136726 - 136726

Published: Nov. 30, 2024

Language: Английский

Citations

1
Identifying ENO1 as a protein target of chlorogenic acid to inhibit cellular senescence and prevent skin photoaging in mice DOI Creative Commons

Xueling He,

Chen Wang, Qianyu Zhang

et al.

Aging Cell, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 31, 2024

Abstract Cellular senescence plays a critical role in repeated ultraviolet (UV) exposure‐induced skin photoaging. Currently, from the perspective of regulating senescent cells, potent compounds or reliable protein targets that could effectively prevent photoaging have not yet been reported. Herein, we demonstrated chlorogenic acid (CGA) significantly inhibited UVA‐induced human dermis fibroblasts (HDF) cells by screening natural product library. The activity‐based profiling (ABPP) result revealed Enolase 1 (ENO1) is one direct CGA HDF cells. Further mechanism research indicated covalently binds to ENO1, and prevented cellular suppressing activity ENO1 block glycolytic pathway. Importantly, found dose‐dependently reduced wrinkle score, alleviated pathological features characteristics mouse model. proteomic analysis treatment senescence‐associated secretory phenotype (SASP) secretion glycolysis samples mice. Collectively, our study only inhibiting cell an effective anti‐skin strategy, but also promising target

Language: Английский

Citations

1
Cadmium and polyvinyl chloride microplastics induce mitochondrial damage and apoptosis under oxidative stress in duck kidney DOI Creative Commons
Hui Zou, Song Jie, Xiang‐Qian Luo

et al.

Poultry Science, Journal Year: 2024, Volume and Issue: 104(1), P. 104490 - 104490

Published: Nov. 12, 2024

Polyvinyl chloride microplastics (PVC-MPs) and Cadmium (Cd) are widely occurring water pollutants that interact with each other to exert toxic effects. As a waterfowl, Muscovy duck is more susceptible PVC-MPs Cd than land poultry. In this study, was used as research model, 10 mg/L 50 mg/kg were alone in combine explore the effect on kidney of duck. We found treatment or changed weight, increased creatinine urea nitrogen content, disrupted oxidative balance macro/trace element metabolism, while combination PVC-MPs+Cd reduced accumulation kidney. addition, caused mitochondrial damage, increase decrease mitochondria-associated proteins (Fis1, Drp1, PGC-1α, Nrf1), Nrf2 signaling pathway plays key role detoxification alleviation stress, we recovered related (Nrf2, Keap-1, HO-1, NQO1, AC-SOD

Language: Английский

Citations

0