Unmasking the Invisible Threat: Biological Impacts and Mechanisms of Polystyrene Nanoplastics on Cells DOI Creative Commons

Wenxia Bu,

Cui Ye, Yan Jin

et al.

Toxics, Journal Year: 2024, Volume and Issue: 12(12), P. 908 - 908

Published: Dec. 14, 2024

Polystyrene nanoplastics (PS-NPs), a pervasive component of plastic pollution, have emerged as significant environmental and health threat due to their microscopic size bioaccumulative properties. This review systematically explores the biological effects mechanisms PS-NPs on cellular systems, encompassing oxidative stress, mitochondrial dysfunction, DNA damage, inflammation, disruptions in autophagy. Notably, induce multiple forms cell death, including apoptosis, ferroptosis, necroptosis, pyroptosis, mediated through distinct yet interconnected molecular pathways. The also highlights various factors that influence cytotoxicity PS-NPs, such particle size, surface modifications, co-exposure with other pollutants, protein corona formation. These complex interactions underscore extensive potentially hazardous impacts health. findings presented here emphasize need for continued research underlying PS-NP toxicity development effective strategies mitigating effects, thereby informing regulatory frameworks aimed at minimizing risks.

Language: Английский

Drosophila melanogaster as a tractable eco-environmental model to unravel the toxicity of micro- and nanoplastics DOI Creative Commons
Yán Wāng, Yang Jiang

Environment International, Journal Year: 2024, Volume and Issue: 192, P. 109012 - 109012

Published: Sept. 17, 2024

Language: Английский

Citations

6
Microplastic Pollution in Soil and Water and the Potential Effects on Human Health: A Review DOI Open Access
Mario Alberto Pérez-Méndez,

Guadalupe Selene Fraga-Cruz,

Saúl Domínguez-García

et al.

Processes, Journal Year: 2025, Volume and Issue: 13(2), P. 502 - 502

Published: Feb. 11, 2025

The presence of microplastics in the environment has increased due to anthropogenic activities; it is estimated that 15 million kilograms plastic waste accumulate ocean annually. Pollution permeates every inch from food chain water bottles floating on surface. This monolith pollution made up all kinds marine debris and contains 1.8 trillion pieces plastic, covering an area twice size Texas. objective this review show advances study emerging problems, specifically soil their potential effects health. In addition, have synergy with residual contaminants exist such as textile waste, organic matter, pathogens, etc. causes damage aquatic organisms makes nutrient transfer more complex many these species. There a report estimates liabilities related will cost industry 100,000 dollars lawsuits for damages losses, which 20,000 occur United States. can generate indicators current effect public policies try control growth pollutant environment. It important discuss routes generation microplastics, distribution, cosmetics involved fast fashion glitter evaluate physical, chemical, biological, toxicological environment, proposing path future be followed regarding research topic.

Language: Английский

Citations

0
Unraveling the Impact of Micro- and Nano-sized Polymethyl methacrylate on Gut Microbiota and Liver Lipid Metabolism: Insights from Oral Exposure Studies DOI

Peng Chen Zheng,

Xin Pan, Yi Zhou

et al.

Environmental Pollution, Journal Year: 2025, Volume and Issue: unknown, P. 126157 - 126157

Published: March 1, 2025

Language: Английский

Citations

0
Exploring the Micro- and Nanoplastics–Diabetes Nexus: Shattered Barriers, Toxic Links, and Methodological Horizons DOI

V.C. Shruti,

Gurusamy Kutralam-Muniasamy, Fermín Pérez‐Guevara

et al.

Environmental Pollution, Journal Year: 2025, Volume and Issue: unknown, P. 126319 - 126319

Published: April 1, 2025

Language: Английский

Citations

0
Toxicity of long term exposure to low dose polystyrene microplastics and nanoplastics in human iPSC-derived cardiomyocytes DOI
Jianyong Ma,

Drew M Ladd,

Necati Kaval

et al.

Food and Chemical Toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 115489 - 115489

Published: April 1, 2025

Language: Английский

Citations

0
Multi-omics reveal toxicity mechanisms underpinning nanoplastic in redclaw crayfish (Cherax quadricarinatus) DOI
Tian Zhu, Chunxia Yao,

Shuang Hong

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 951, P. 175680 - 175680

Published: Aug. 22, 2024

Language: Английский

Citations

1
The Effects of Nanoplastics on the Dopamine System of Cerebrocortical Neurons DOI
Nahyun Kim, Young‐A Lee

International Journal of Toxicology, Journal Year: 2024, Volume and Issue: 44(1), P. 29 - 38

Published: Nov. 1, 2024

Nanoplastics (NPx) can enter living organisms, including humans, through ecosystems, inhalation, and dermal contact be found from the intestine to brain. However, it is unclear whether NPx accumulates affects dopamine system. In this study, we investigated effects of on system in cultured murine cerebral cortex neurons. Cultured cerebrocortical neurons were treated with 100 nm at following concentrations for 24 h: 1.896 × 105, 3.791 106, 7.583 107, 1.571 109, 3.033 1010, 1011 particles/mL. Dopamine-associated proteins analyzed using immunofluorescence staining. treatment induced its accumulation a dose-dependent manner increased levels receptors D1 D2 their co-expression. did not affect other receptors, transporters, tyrosine hydroxylase, microtubule-associated protein 2, or synaptophysin neuronal structures. This study demonstrated that potential modulator via rather than synthesis reuptake may associated dopamine-based psychiatric disorders.

Language: Английский

Citations

0
Proteomics reveals that nanoplastics with different sizes induce hepatocyte apoptosis in mice through distinct mechanisms involving mitophagy dysregulation and cell cycle arrest DOI

Yanyang Lu,

Weizhen Hua,

Yiqiong Sun

et al.

Toxicology Research, Journal Year: 2024, Volume and Issue: 13(6)

Published: Nov. 5, 2024

Nanoplastics (NPs) can penetrate the intestinal barrier of organisms and accumulate in liver, thereby inducing hepatocyte apoptosis. However, underlying mechanisms remain incompletely elucidated. This study examined effects PS-NPs exposure on apoptosis revealed role cell cycle arrest mitophagy. The C57BL/6 mice were administered a diet containing 100 nm 500 at concentration 0.1 g/kg for 180 days, respectively. TUNEL staining confirmed that induced more pronounced compared to mouse liver. Mechanistically, proteomic analysis Pdcd2l, associated with S phase apoptosis, exhibited highest fold changes among all detected proteins groups. Notably, expression Tbc1d17, Bcl2l13, Pgam5 involved mitophagosome formation liver was upregulated by but not PS-NPs; moreover, mitophagosomes observed HepG2 cells exposed PS-NPs. Additionally, internalized could lysosomes. protein levels Igf2r Rab7a altered,

Language: Английский

Citations

0
Reversibility of polystyrene nanoplastics-induced disruption of testosterone biosynthesis in mice: The role of histone modifications DOI

Yanyang Lu,

Rui Yang,

Meiyi Cao

et al.

Environmental Pollution, Journal Year: 2024, Volume and Issue: 366, P. 125506 - 125506

Published: Dec. 9, 2024

Language: Английский

Citations

0
Unmasking the Invisible Threat: Biological Impacts and Mechanisms of Polystyrene Nanoplastics on Cells DOI Creative Commons

Wenxia Bu,

Cui Ye, Yan Jin

et al.

Toxics, Journal Year: 2024, Volume and Issue: 12(12), P. 908 - 908

Published: Dec. 14, 2024

Polystyrene nanoplastics (PS-NPs), a pervasive component of plastic pollution, have emerged as significant environmental and health threat due to their microscopic size bioaccumulative properties. This review systematically explores the biological effects mechanisms PS-NPs on cellular systems, encompassing oxidative stress, mitochondrial dysfunction, DNA damage, inflammation, disruptions in autophagy. Notably, induce multiple forms cell death, including apoptosis, ferroptosis, necroptosis, pyroptosis, mediated through distinct yet interconnected molecular pathways. The also highlights various factors that influence cytotoxicity PS-NPs, such particle size, surface modifications, co-exposure with other pollutants, protein corona formation. These complex interactions underscore extensive potentially hazardous impacts health. findings presented here emphasize need for continued research underlying PS-NP toxicity development effective strategies mitigating effects, thereby informing regulatory frameworks aimed at minimizing risks.

Language: Английский

Citations

0