Bile acids as a key target: traditional Chinese medicine for precision management of insulin resistance in type 2 diabetes mellitus through the gut microbiota-bile acids axis DOI Creative Commons

Yu Wang,

Jing Yu,

Binqin Chen

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 10, 2024

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease caused by insulin resistance (IR) and insufficient secretion. Its characteristic pathophysiological processes involve the interaction of multiple mechanisms. In recent years, globally, prevalence T2DM has shown sharp rise due to profound changes in socio-economic structure, persistent influence environmental factors, complex role genetic background. It worth noting that most patients show significant IR, which further exacerbates difficulty progression prevention. process extensively exploring pathogenesis T2DM, dynamic equilibrium gut microbes its diverse activities have increasingly emphasized central T2DM. Bile acids (BAs) metabolism, as crucial link between development not only precisely regulates lipid absorption metabolism but also profoundly influences glucose homeostasis energy balance through intricate signaling pathways, thus playing pivotal IR This review aims delve into specific mechanism BAs contribute especially emphasizing how mediate transformation based on current traditional Chinese medicine research. Ultimately, it seeks offer new insights prevention treatment Diet, genetics, environment intricately sculpt microbiota influencing T2DM-IR. The research illuminated impact single herbal medicine, TCM formulae, external therapeutic methods such electroacupuncture pool perturbations structure. affects well sensitivity. Additionally, pathways including BA-FXR-SHP, BA-FXR-FGFR15/19, BA-FXR-NLRP3, BA-TGR5-GLP-1, BAs-TGR5/FXR been identified significantly alter blood levels improve IR. These findings novel approaches for enhancing managing disorders among with

Language: Английский

Sex- and trimester-specific impact of gestational co-exposure to organophosphate esters and phthalates on insulin action among preschoolers: Findings from the Ma’anshan birth cohort DOI Creative Commons

Hong Gan,

Mengjuan Lu,

Juan Tong

et al.

Environment International, Journal Year: 2025, Volume and Issue: 196, P. 109287 - 109287

Published: Jan. 18, 2025

Prenatal exposure to organophosphate esters (OPEs) and phthalic acid (PAEs) is ubiquitous among pregnant individuals. However, research exploring the relationship between prenatal co-exposure OPEs PAEs childhood insulin function remains limited. In this study, utilizing data from 2,246 maternal-fetal dyads in Ma'anshan Birth Cohort, associations action were analyzed. Repeated measures of tris (2-chloroethyl) phosphate, six OPE metabolites, seven PAE metabolites collected maternal urine. Homeostasis model assessment resistance (HOMA-IR) index (IAI) served as outcome measures. After adjusting for potential confounders, effects repeated on evaluated using generalized estimating equations, while mixture assessed through BayesianKernel Machine Regression Quantile-Based G-Computation. The average age children at time study was 5.33 years. analysis revealed that MEP positively associated with increased HOMA-IR (β, 0.027; 95 % CI: 0.002, 0.053), IAI inversely correlated rising levels 0.025; -0.046, -0.004) MEHHP -0.128; -0.218, -0.037). Mixed modeling further indicated linked 0.058; 0.001, 0.114) negatively -0.054; -0.097, -0.010), stronger observed during second trimester. Notably, association more pronounced female compared males. This provides first epidemiological evidence highlighting pregnancy- sex-specific links action.

Language: Английский

Citations

1
Liquid and gas-chromatography-mass spectrometry methods for exposome analysis DOI
Victor Castro‐Alves, Nguyễn Hoàng Anh, João Marcos G. Barbosa

et al.

Journal of Chromatography A, Journal Year: 2025, Volume and Issue: unknown, P. 465728 - 465728

Published: Jan. 1, 2025

Language: Английский

Citations

1
Dose‐Dependent Hepatorenal Damage Induced by Erythrosine: A Study of Biochemical, Oxidative Stress, DNA Damage, and Histopathological Effects in Wistar Rats DOI Creative Commons
Mandeep Singh, Pooja Chadha

Journal of Applied Toxicology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

ABSTRACT This study aimed to provide insights into the hepatorenal toxicity induced by erythrosine, a synthetic red dye commonly used in food and pharmaceuticals, which has raised concerns over its potential health risks. Twenty‐four rats were randomly divided four groups ( n = 6). The first group was control other received one of three doses erythrosine based on acceptable daily intake (¼ ADI, ½ 0.1 mg/kg body weight). examined biological activity via biochemical enzyme analysis, oxidative stress indices, DNA damage, histopathology. Compared with group, administration increased serum alanine aminotransferase, aspartate alkaline phosphatase, total bilirubin, protein, urea, creatinine, uric acid at highest dose. catalase superoxide dismutase decreased both tissues glutathione‐S‐transferase ¼ ADI dose higher tissues. In contrast, acetylcholinesterase greater erythrosine‐treated than rats. Oxidative indices indicated lipid peroxidation, hydrogen peroxide content, lactate dehydrogenase activity. comet assay assess revealing significant damage groups. Histopathological examination revealed necrotic degenerative changes liver kidney findings underscore dose‐dependent highlight novelty demonstrating comprehensive link between exposure, stress, damage. These results emphasize need for cautious evaluation consumption due

Language: Английский

Citations

0
Overview of the hazardous impacts of metabolism-disrupting chemicals on the progression of fatty liver diseases DOI Creative Commons

G.-H. An,

Jinyeop Song, Wei Ying

et al.

Molecular & Cellular Toxicology, Journal Year: 2025, Volume and Issue: 21(2), P. 387 - 397

Published: Feb. 27, 2025

Given the global increase in obesity, metabolic dysfunction-associated steatotic liver disease (MASLD) is a major health concern. Because primary organ for xenobiotic metabolism, impact of environmental stressors on homeostasis and MASLD has garnered significant interest over past few decades. The concept metabolism-disrupting chemicals (MDCs) been introduced to underscore importance factors homeostasis. Recent epidemiological biological studies suggest causal link between exposure MDCs prevalence progression MASLD. This review aims introduce emerging their representative toxic mechanisms. In particular, this focuses broadening understanding impacts or steatohepatitis (MASH) progression. research highlighted contaminants, such as heavy metals, microplastics, pesticides, have potential influence hepatic metabolism aggravate MASLD/MASH These not only directly affect lipid hepatocytes but also other cell types, immune cells stellate cells, well gut-liver axis. Collectively, these findings contribute establishing well-defined adverse outcome pathway identify novel therapeutic options diseases associated with pollutants.

Language: Английский

Citations

0
Urinary Metabolomics of Plastic Manufacturing Workers: A Pilot Study DOI Creative Commons
Michele De Rosa, Ottavia Giampaoli, A. Patriarca

et al.

Journal of Xenobiotics, Journal Year: 2025, Volume and Issue: 15(2), P. 39 - 39

Published: March 4, 2025

The plastic manufacturing industry has a crucial role in the global economy with significant impact wide range of fields. chemical risk to which workers are potentially exposed is difficult characterize and strictly related both products processes adopted. Among chemicals used, we can cite styrene, phenol, butadiene phthalates, but nano- microplastic particles also be released work environment. In this pilot study, present for first time an NMR-based metabolomic approach assessing urinary profiles employed company. Urine samples from twelve thirteen healthy volunteers were collected analyzed by NMR spectroscopy. Forty-six metabolites belonging different classes univocally identified quantified. dataset so obtained was then subjected multivariate statistical analysis each profile highlight any differences. An alteration some involved several pathways, such as amino acid metabolism NAD metabolism, found, strong on gut microflora speculated. Ultimately, our objective adding tile knowledge biological effects possibly occupational exposure even if it below threshold limit values.

Language: Английский

Citations

0
Per- and polyfluoroalkyl substances mixture impairs intestinal barrier function through microbiota-derived 21-deoxycortisol and cortisol metabolism dysregulation DOI
Tingting Lin,

Luyang He,

Sishuo Liu

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: unknown, P. 138378 - 138378

Published: April 1, 2025

Language: Английский

Citations

0
Per- and polyfluoroalkyl substances (PFASs) Exposure and Gastric Cancer Risk: Insights from Exposome-Metabolome Profiling DOI Creative Commons

Juan Zhu,

Sainan Li, Xue Li

et al.

Environmental Technology & Innovation, Journal Year: 2025, Volume and Issue: unknown, P. 104242 - 104242

Published: May 1, 2025

Language: Английский

Citations

0
PFAS Exposure and Kidney Health with Gut Microbiota, Blood Metabolites, and Multi-Organ Implications Across Medical Specialties DOI
Nicholas A Kerna,

Adina Boulos,

Melany Abreu

et al.

European journal of ecology, biology and agriculture., Journal Year: 2025, Volume and Issue: 2(2), P. 30 - 46

Published: March 1, 2025

PFAS (per- and polyfluoroalkyl substances) exposure has been linked to kidney damage through mechanisms involving gut microbiota dysbiosis alterations in blood metabolites. These disruptions trigger renal inflammation, oxidative stress, metabolic dysregulation, impairing function. significantly alters microbial communities, impacting metabolites like short-chain fatty acids (SCFAs), bile acids, trimethylamine N-oxide (TMAO). imbalances contribute chronic inflammation fibrosis the gut-kidney axis. Additionally, disrupts related energy metabolism, mitochondrial function, lipid oxidation, amino acid metabolism. Biomarkers such as uric acid, creatinine, homocysteine indicate nephrotoxic stress. This paper explores potential by which impact health interactions with It also highlights its effects role affecting multiple body systems that may involve various medical specialists, internists, gastroenterologists, cardiologists, obstetricians, gynecologists, psychiatrists.

Language: Английский

Citations

0
Triphenyl phosphate induces lipid metabolism disorder and promotes obesity through PI3K/AKT signaling pathway DOI Creative Commons

Tianlan Li,

Yiwa Liu,

Jingyi Cao

et al.

Environment International, Journal Year: 2025, Volume and Issue: 198, P. 109428 - 109428

Published: April 1, 2025

Triphenyl phosphate (TPHP) is a widely used organic flame retardant that has been reported as potential environmental obesogen. However, the impact and mechanism of action TPHP on adipose tissue are still unclear. This study investigates lipid metabolism disorders through in vivo vitro experiments. Male female BALB/c mice were exposed to (0, 1, 10, 150 mg/kg/day) for 60 days, 3T3-L1 preadipocytes treated with concentrations 0.1, 10 μM) during differentiation. The results showed exposure could cause gender specific dyslipidemia, male exhibiting dose-dependent increases inguinal coefficient, adipocyte hypertrophy, upregulation differentiation adipogenesis-related genes. In contrast, did not show significant changes morphology. suggested might promote occurrence adiposity by disrupting homeostasis tissue. During maturation process preadipocytes, led increased accumulation disrupted simultaneous activation adipogenesis lipolysis. Multiple omics data peroxisome proliferator-activated receptor γ (PPARγ) signaling pathway fatty acid was core induced metabolic dysfunction. Further research activated PI3K/AKT pathway, PI3K inhibitor (LY294002) rescue droplet formation normalize expression adipogenic markers. These findings confirm obesogen can disrupt white PPARγ pathways, higher susceptibility males. provides compelling evidence obesogenic effects information risk assessment organophosphorus retardants.

Language: Английский

Citations

0
Lead promoted bile acid deconjugation by modulating gut bacteria encoding bile salt hydrolase (BSH) in Rana chensinensis tadpoles DOI
Ying Liu,

Yanchun Pei,

Hongyuan Wang

et al.

Environmental Pollution, Journal Year: 2025, Volume and Issue: unknown, P. 126187 - 126187

Published: April 1, 2025

Language: Английский

Citations

0