High-Resolution Mass Spectrometry for Human Exposomics: Expanding Chemical Space Coverage
Environmental Science & Technology,
Journal Year:
2024,
Volume and Issue:
58(29), P. 12784 - 12822
Published: July 10, 2024
In
the
modern
"omics"
era,
measurement
of
human
exposome
is
a
critical
missing
link
between
genetic
drivers
and
disease
outcomes.
High-resolution
mass
spectrometry
(HRMS),
routinely
used
in
proteomics
metabolomics,
has
emerged
as
leading
technology
to
broadly
profile
chemical
exposure
agents
related
biomolecules
for
accurate
measurement,
high
sensitivity,
rapid
data
acquisition,
increased
resolution
space.
Non-targeted
approaches
are
increasingly
accessible,
supporting
shift
from
conventional
hypothesis-driven,
quantitation-centric
targeted
analyses
toward
data-driven,
hypothesis-generating
exposome-wide
profiling.
However,
HRMS-based
exposomics
encounters
unique
challenges.
New
analytical
computational
infrastructures
needed
expand
analysis
coverage
through
streamlined,
scalable,
harmonized
workflows
pipelines
that
permit
longitudinal
tracking,
retrospective
validation,
multi-omics
integration
meaningful
health-oriented
inferences.
this
article,
we
survey
literature
on
state-of-the-art
technologies,
review
current
informatic
pipelines,
provide
an
up-to-date
reference
exposomic
chemists,
toxicologists,
epidemiologists,
care
providers,
stakeholders
health
sciences
medicine.
We
propose
efforts
benchmark
fit-for-purpose
platforms
expanding
space,
including
gas/liquid
chromatography-HRMS
(GC-HRMS
LC-HRMS),
discuss
opportunities,
challenges,
strategies
advance
burgeoning
field
exposome.
Language: Английский
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