Molecular insight into reproductive toxicity and transgenerational effects of Cadmium exposure on Drosophila melanogaster

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 291, P. 117870 - 117870

Published: Feb. 1, 2025

Cadmium (Cd), a widespread and serious environmental pollutant, has recently garnered increasing scientific scrutiny due to its profound adverse effects. Although the evidence for Cd-induced reproductive toxicity is well established, it remains elusive on intricate dose-response relationship underlying molecular mechanisms, especially transgenerational in animals. Here, we employed fruit fly (Drosophila melanogaster) as model organism examine performance across five generations by parental exposure varying concentrations of Cd (5, 50, 500 μM). Firstly, our observations number eggs laid, pupae formed, adult flies emerged directly exposed generation (F0) confirmed dose-dependent decline fecundity. Transcriptome analysis revealed that, oxidative stress ion transport disruption F0 could underlie synaptic dysfunction impaired follicle cell development, impacting behavior oocyte fertility. Employing analysis, Wnt signaling pathway mTOR were identified early responses toxicity. Secondly, sustained detrimental effects observed at least two three after removal. At epigenetic level, perturb fecundity modulating Dnmt2 expression, pivotal regulator methylation processes. Moreover, despite phenotypic recovery F4, persistent changes indicate enduring toxicity, highlighting need vigilance against contamination long-term Collectively, findings enhance understanding effects, highlight further improve assessment multigenerational consequences contamination.

Language: Английский

Insights into the synergistic toxicity mechanisms caused by nano- and microplastics with triclosan using a dose-dependent functional genomics approach in Saccharomyces cerevisiae

Chemosphere, Journal Year: 2024, Volume and Issue: 362, P. 142629 - 142629

Published: June 15, 2024

Language: Английский

Mechanism-based toxicity screening of organophosphate flame retardants using Tox21 assays and molecular docking analysis

Chemosphere, Journal Year: 2024, Volume and Issue: 368, P. 143772 - 143772

Published: Nov. 1, 2024

Language: Английский