THE EFFECT OF NANOPLASTICS AND MICROPLASTICS ON LUNG MORPHOLOGY AND PHYSIOLOGY: A SYSTEMATIC REVIEW DOI Creative Commons

Y.V. Rybalchenko

The Medical and Ecological Problems, Journal Year: 2024, Volume and Issue: 28(3), P. 42 - 60

Published: Dec. 30, 2024

Airborne microplastic (NP) and nanoplastic (MP) pollution has emerged as a pressing environmental concern with significant implications for human health. While MPs are present both indoors outdoors, indoor concentrations generally higher due to the abrasion of household materials, furniture, other domestic sources. NPs, when inhaled, accumulate in various lung regions, exerting toxic effects potentially leading respiratory diseases. This systematic review, conducted according PRISMA guidelines, evaluates recent experimental studies on pathogenic impact nanomicroplastics (NMPs) tissues using vivo vitro models. The review included 10 analyzing MP accumulation 90 examining pathogenetic mechanisms exposure. Research data indicates predominance polymeric fibers such polypropylene, polyethylene terephthalate, polytetrafluoroethylene, accounting nearly half structures. NMPs exhibit size- composition-dependent accumulation, smaller positively charged particles showing translocation potential systemic circulation organs. highlights synergistic heavy metals pollutants, interaction pulmonary surfactant, role exacerbating Current analysis underscores growing interest NMP-related health risks identifies knowledge gaps, including need standardization NMP toxicity testing further exploration biological systems. findings emphasize importance mitigating exposure safeguard pave way future research long-term impacts airborne

Language: Английский

A particle of concern: explored and proposed underlying mechanisms of microplastic-induced lung damage and pulmonary fibrosis DOI
R. K. Gautam,

Laltanpuia,

Nishant Singh

et al.

Inhalation Toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 17

Published: Feb. 11, 2025

In the past decade, microplastics (MPs) have drawn significant attention as widespread environmental contaminants, with research increasingly highlighting their harmful effects on respiratory health in aquatic and terrestrial organisms. Findings revealed human lung tissues, raising concerns about potential role damaging tissue integrity contributing to pulmonary fibrosis-a chronic inflammatory condition characterized by scarring of epithelial tissues due accumulated extracellular matrix, triggered factors such alcohol, pathogens, genetic mutations, pollutants. this review, we explore both well-studied lesser-studied mechanisms signaling pathways, aiming shed light how might act mediators that activate distinct, often overlooked cascades. This review searched PubMed Google Scholar using keywords like "plastic," "microplastic," "lung fibrosis," "pulmonary system," "exposure route," "signaling pathways," combined "OR" "AND" singular plural forms. These pathways could not only induce damage but also play a development fibrosis. be targeted reduce microplastic-induced fibrosis, opening new avenues for future treatments.

Language: Английский

Citations

1
Drosophila melanogaster as a tractable eco-environmental model to unravel the toxicity of micro- and nanoplastics DOI Creative Commons
Yán Wāng, Yang Jiang

Environment International, Journal Year: 2024, Volume and Issue: 192, P. 109012 - 109012

Published: Sept. 17, 2024

Language: Английский

Citations

6
Biological Effects of Micro-/Nano-Plastics in Macrophages DOI Creative Commons
Massimiliano G. Bianchi, Lavinia Casati,

Giulia Sauro

et al.

Nanomaterials, Journal Year: 2025, Volume and Issue: 15(5), P. 394 - 394

Published: March 4, 2025

The environmental impact of plastics is worsened by their inadequate end-of-life disposal, leading to the ubiquitous presence micro- (MPs) and nanosized (NPs) plastic particles. MPs NPs are thus widely present in water air inevitably enter food chain, with inhalation ingestion as main exposure routes for humans. Many recent studies have demonstrated that gain access several body compartments, where they taken up cells, increase production reactive oxygen species, lead inflammatory changes. In most tissues, resident macrophages engage first approach foreign materials, this interaction largely affects subsequent fate material possible pathological outcomes. On other hand, organizers controllers both responses tissue repair. Here, we aim summarize available information on NPs. Particular attention will be devoted consequences macrophage viability functions, well implications pathology.

Language: Английский

Citations

0
Impacts of Microplastic Pollution on the Environment and its Effective Treatment – A Review DOI

Masilamani Shanmugaraja,

P. Kanagaraj,

B. Thangagiri

et al.

Water Air & Soil Pollution, Journal Year: 2024, Volume and Issue: 235(8)

Published: July 3, 2024

Language: Английский

Citations

1
THE EFFECT OF NANOPLASTICS AND MICROPLASTICS ON LUNG MORPHOLOGY AND PHYSIOLOGY: A SYSTEMATIC REVIEW DOI Creative Commons

Y.V. Rybalchenko

The Medical and Ecological Problems, Journal Year: 2024, Volume and Issue: 28(3), P. 42 - 60

Published: Dec. 30, 2024

Airborne microplastic (NP) and nanoplastic (MP) pollution has emerged as a pressing environmental concern with significant implications for human health. While MPs are present both indoors outdoors, indoor concentrations generally higher due to the abrasion of household materials, furniture, other domestic sources. NPs, when inhaled, accumulate in various lung regions, exerting toxic effects potentially leading respiratory diseases. This systematic review, conducted according PRISMA guidelines, evaluates recent experimental studies on pathogenic impact nanomicroplastics (NMPs) tissues using vivo vitro models. The review included 10 analyzing MP accumulation 90 examining pathogenetic mechanisms exposure. Research data indicates predominance polymeric fibers such polypropylene, polyethylene terephthalate, polytetrafluoroethylene, accounting nearly half structures. NMPs exhibit size- composition-dependent accumulation, smaller positively charged particles showing translocation potential systemic circulation organs. highlights synergistic heavy metals pollutants, interaction pulmonary surfactant, role exacerbating Current analysis underscores growing interest NMP-related health risks identifies knowledge gaps, including need standardization NMP toxicity testing further exploration biological systems. findings emphasize importance mitigating exposure safeguard pave way future research long-term impacts airborne

Language: Английский

Citations

0