Toxics,
Journal Year:
2024,
Volume and Issue:
12(12), P. 853 - 853
Published: Nov. 26, 2024
The
highly
hazardous
chemical
ammonia
has
been
proven
to
be
absorbed
by
nanoparticles,
thereby
exerting
toxic
effects
on
aquatic
organisms.
As
a
ubiquitous
pollutant
in
environments,
polystyrene
nanomicroplastics
(PSNPs)
have
shown
strong
adsorption
capacity
due
their
large
surface
area.
Therefore,
the
potential
joint
of
and
PSNPs
need
clarified.
In
this
study,
zebrafish
embryos
were
exposed
water
solution
with
concentrations
(0,
0.1,
1,
10
mg/L)
or
without
PSNP
(100
μg/L)
treatment
up
120
hpf.
results
showed
that
combined
exposure
increased
accumulation
obviously
reduced
locomotor
speed
larvae
compared
alone.
Further
studies
indicated
can
aggravate
ammonia-induced
neurotoxicity
altering
cholinergic
system,
dopaminergic
neurons,
retinal
structure
larvae.
addition,
our
revealed
caused
significant
alterations
expression
genes
related
neurodevelopment
development,
exacerbated
adverse
effect.
conclusion,
early
stage
associated
health
risk
animals
should
not
underestimated.
main
contribution
article
lies
revealing
synergistic
zebrafish.
Moreover;
it
emphasizes
risks
Ecotoxicology and Environmental Safety,
Journal Year:
2024,
Volume and Issue:
278, P. 116426 - 116426
Published: May 8, 2024
The
increase
of
micro-
and
nano-plastics
(MNPs)
in
aquatic
environments
has
become
a
significant
concern
due
to
their
potential
toxicological
effects
on
ecosystems,
food
web
dynamics,
human
health.
These
plastic
particles
emerge
from
range
sources,
such
as
the
breakdown
larger
waste,
consumer
products,
industrial
outputs.
This
review
provides
detailed
report
transmission
dangers
MNPs
environmental
behavior,
interactions
within
webs,
emphasizing
toxic
impact
marine
life.
It
explores
relationship
between
particle
size
toxicity,
distribution
different
tissues,
process
trophic
transfer
through
web.
MNPs,
once
consumed,
can
be
found
various
organs,
including
digestive
system,
gills,
liver.
Their
consumption
by
lower
level
organisms
facilitates
progression
up
chain,
potentially
leading
bioaccumulation
biomagnification,
thereby
posing
substantial
risks
health,
reproduction,
behavior
species.
work
also
how
persistence
bioaccumulation,
pose
biodiversity
disrupt
relationships.
addresses
implications
for
particularly
contaminated
seafood,
highlighting
direct
indirect
pathways
which
humans
are
exposed
these
pollutants.
Furthermore,
highlights
recommendations
future
research
directions,
integration
ecological,
toxicological,
health
studies
inform
risk
assessments
develop
mitigation
strategies
address
global
challenge
pollution
environments.
Toxics,
Journal Year:
2025,
Volume and Issue:
13(2), P. 82 - 82
Published: Jan. 24, 2025
This
study
investigates
the
toxic
effects
of
ketamine
on
juvenile
zebrafish,
driven
by
increasing
concerns
over
ketamine’s
prevalence
and
its
potential
neurotoxic
that
may
disrupt
behavior
metabolism.
Employing
a
high-throughput
tracking
system,
research
analyzed
locomotor
activity
6-day
post-fertilization
(6
dpf)
zebrafish
exposed
to
various
concentrations
ketamine.
The
integration
behavioral
analysis
with
metabolic
profiling
was
notable
innovation,
as
it
establishes
comprehensive
understanding
both
acute
inhibition
responses.
findings
reveal
exposure
significantly
inhibits
in
these
becoming
more
pronounced
at
higher
concentrations.
Additionally,
detection
normethketamine,
primary
metabolite
ketamine,
using
UPLC-LTQ/Orbitrap
HRMS,
confirms
zebrafish’s
ability
metabolize
drug.
underscores
utility
model
organism
for
studying
impact
metabolism,
providing
valuable
insights
extend
other
vertebrates.
