Seabirds in crisis: Plastic ingestion induces proteomic signatures of multiorgan failure and neurodegeneration

Science Advances, Journal Year: 2025, Volume and Issue: 11(11)

Published: March 12, 2025

Understanding plastics’ harmful impacts on wildlife would benefit from the application of hypothesis agnostic testing commonly used in medical research to detect declines population health. Adopting a data-driven, proteomic approach, we assessed changes 745 proteins free-living nonmodel organism with differing levels plastic exposure. Seabird chicks heavily affected by ingestion demonstrated range negative health consequences: Intracellular components that should not be found blood were frequently detected, indicative cell lysis. Secreted less abundant, indicating stomach, liver, and kidneys are functioning as normal. Alarmingly, these signatures included evidence neurodegeneration <90-day-old seabird high ingested plastic. The reflect effects distal site exposure (i.e., stomach). Notably, metrics assess condition (such body mass) do provide an accurate description or ingestion.

Language: Английский

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Chitosan/water caltrop pericarp extract reinforced active edible film and its efficacy as strawberry coating for prolonging shelf life

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142115 - 142115

Published: March 1, 2025

Language: Английский

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What Does the “Trojan Horse” Carry? The Pollutants Associated with Microplastics/Nanoplastics in Water Environments

ACS ES&T Water, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

Language: Английский

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Metabolic Dysfunction-Associated Steatotic Liver Disease Induced by Microplastics: An Endpoint in the Liver–Eye Axis

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 2837 - 2837

Published: March 21, 2025

There is a significant, rather than just anecdotal, connection between the liver and eyes. This evident in noticeable cases such as jaundice, where sclera has yellow tint. But this can be seen through even more subtle indicators, molecules known hepatokines. relationship not merely anecdotal; some studies, it referred to “liver–eye axis”. Ubiquitous environmental contaminants, microplastics (MPs), enter bloodstream human body conjunctival sac, nasolacrimal duct, upper respiratory tract mucosa. Once absorbed, these substances accumulate various organs cause harm. Toxic from surface of eye lead local oxidative damage by inducing apoptosis corneal cells, irregularly shaped microparticles exacerbate effect. Even other toxicants ocular may absorbed into distributed throughout body. Environmental toxicology presents challenge because many pollutants same route that used certain medications. Previous research indicated accumulation MPs play major role development chronic disease humans. It crucial investigate whether buildup potential fibrosis, or simply consequence conditions cirrhosis portal hypertension.

Language: Английский

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Microplastics: An emerging environmental risk factor for gut microbiota dysbiosis and cancer development?

Environmental Chemistry and Ecotoxicology, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

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Interaction of Polystyrene Nanoplastics with Biomolecules and Environmental Pollutants: Effects on Human Hepatocytes

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 2899 - 2899

Published: March 22, 2025

The inevitable exposure of humans to micro/nanoplastics has become a pressing global environmental issue, with growing concerns regarding their impact on health. While the direct effects human health remain largely unknown, increasing attention is being given potential role as carriers pollutants and organic substances. This study investigates toxicity 500 nm polystyrene nanoplastics (NPs) hepatocytes (HepG2) in vitro, both alone combination cadmium (Cd), hazardous heavy metal prevalent pollutant. One-hour 100 µg/mL NPs causes significant increase ROS production (+25% compared control) but cell viability remains unaffected even at concentrations much higher than levels. Interestingly, significantly reduce Cd cytotoxicity LC50 (cell control: 55.4% for 50 µM Cd, 66.9% + 10 NPs, 68.4% NPs). Additionally, do not alter cellular lipid content after short-term (24 h). However, when fatty acids are added medium, appear sequester acids, reducing availability impairing uptake by cells dose-dependent manner. We confirmed Dynamic Light Scattering Scanning Electron Microscopy interaction between free acids. Although exhibited minimal our experimental model, collectively findings suggest that predicting extremely challenging, due specific components biological matrix.

Language: Английский

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Tackling microplastic contamination in sewage sludge: Optimizing organic matter degradation, quantifying microplastic presence, and evaluating ecological risks for sustainable agriculture

The Science of The Total Environment, Journal Year: 2025, Volume and Issue: 974, P. 179201 - 179201

Published: March 27, 2025

Language: Английский

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In vivo and In vitro assessment of the retinal toxicity of polystyrene nanoplastics

Environment International, Journal Year: 2025, Volume and Issue: 198, P. 109420 - 109420

Published: March 30, 2025

Language: Английский

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zMicroplastics and nanoplastics co-exposure modulates chromium bioaccumulation and physiological responses in rats

Environment International, Journal Year: 2025, Volume and Issue: unknown, P. 109421 - 109421

Published: March 1, 2025

The environmental fragmentation of plastics generates a mixture plastic particles various sizes, which frequently co-occur with other mobile and persistent pollutants. Despite the prevalence such scenarios, interaction between micro- nanoplastics (MNPs) their combined effects pollutants, as highly toxic hexavalent chromium (Cr(VI)), remain almost entirely unexplored in mammalian species. This study demonstrated that nanoplastic microplastic co-aggregate together influence Cr bioaccumulation patterns related physiological alterations rats. Following four-week repeated intragastric exposure Wistar rats to MNPs Cr(VI), either alone or combination, significantly enhanced liver, heart, brain, skin. Under co-exposure conditions, Cr(VI) was primary driver cellular observed blood, including shifts immune cell subpopulations (e.g., neutrophils, lymphocytes) red blood indices, while serum biochemistry reflected limited stress. per se decreased creatine kinase activity increased cholesterol levels. In summary, polystyrene increase distribution bioavailability, but does not uniformly exacerbate toxicity. Instead, may selectively alter responses, emphasizing need for deeper understanding potential health risks.

Language: Английский

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“The paper cups Nile”: microplastics and other hazardous substances leached from paper cups: paper cups aquatic environmental bane in the River Nile, Egypt

Frontiers in Environmental Science, Journal Year: 2025, Volume and Issue: 13

Published: April 1, 2025

Recent studies suggest that paper cups may also contribute to environmental pollution, particularly through the release of microplastics (MPs). The Nile River, one world’s most vital water sources, faces alarming contamination levels, raising concerns about its ecological health. This study investigated whether MPs, ions, and heavy metals into assessed potential impact MPs on fish. In order completely comprehend nature scope issue, 1 L was collected from River in Assiut, Egypt were ripped tiny pieces. Paper similarly soaked similar volumes distilled tap water. Four months later, leachate each trail (three replicates for each) analyzed determine compare distribution specific microplastics. clarify availability freshwater fish, intestines two common fish species ( Oreochromis niloticus Bagrus bajad ) Assiut examined. Polyethylene, polystyrene polypropylene three main forms identified samples Nile. Also, leached same groups but lower amounts. Some take longer biodegrade water, as evidenced by absence other like rayon polyvinyl chloride any under investigation. present findings indicate a noteworthy accumulation O. B. . conclusion, these results indicated some metals, is polluted with which have negative effect aquatic organisms. brings us step closer investigating fully understanding extent problem posed their effects will ultimately be reflected human health risks.

Language: Английский

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