High-Resolution Tracking of Aging-Related Small Molecules: Bridging Pollutant Exposure, Brain Aging Mechanisms, and Detection Innovations
Keying Yu,
No information about this author
Soo In Yang,
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H.-P. Song
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et al.
Biosensors,
Journal Year:
2025,
Volume and Issue:
15(4), P. 242 - 242
Published: April 11, 2025
Brain
aging
is
a
complex
process
regulated
by
genetic,
environmental,
and
metabolic
factors,
increasing
evidence
suggests
that
environmental
pollutants
can
significantly
accelerate
this
interfering
with
oxidative
stress,
neuroinflammation,
mitochondrial
function-related
signaling
pathways.
Traditional
studies
have
focused
on
the
direct
damage
of
macromolecules
(e.g.,
proteins,
DNA),
while
central
role
senescence-associated
small
molecules
ROS,
PGE2,
lactate)
in
early
regulatory
mechanisms
has
been
long
neglected.
In
study,
we
innovatively
proposed
cascade
framework
"small
molecule
imbalance-signaling
pathway
dysregulation-macromolecule
collapse",
which
reveals
exacerbate
dynamics
brain
through
activation
NLRP3
inflammatory
vesicles
inhibition
HIF-1α.
Meanwhile,
to
address
technical
bottleneck
spatiotemporal
monitoring,
paper
systematically
reviews
cutting-edge
detection
tools
such
as
electrochemical
sensors,
genetically
encoded
fluorescent
probes
antioxidant
quantum
dots
(AQDs).
Among
them,
AQDs
show
unique
advantages
real-time
monitoring
ROS
fluctuations
intervention
virtue
their
ultra-high
specific
surface
area,
controllable
modification,
free
radical
scavenging
ability.
By
integrating
multimodal
techniques
mechanism
studies,
work
provides
new
perspective
for
analyzing
pollutant-induced
lays
methodological
foundation
strategies
based
networks.
Language: Английский
Urban Air Quality Shifts in China: Application of Additive Model and Transfer Learning to Major Cities
Yuchen Ji,
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Xiaonan Zhang,
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Yueqian Cao
No information about this author
et al.
Toxics,
Journal Year:
2025,
Volume and Issue:
13(5), P. 334 - 334
Published: April 24, 2025
The
impact
of
reduced
human
activity
on
air
quality
in
seven
major
Chinese
cities
was
investigated
by
utilizing
datasets
pollutants
and
meteorological
conditions
from
2016
to
2021.
A
Generalized
Additive
Model
(GAM)
developed
predict
during
reduced-activity
periods
rigorously
validated
against
ground
station
measurements,
achieving
an
R2
0.85–0.93.
Predictions
were
compared
the
observed
pollutant
reductions
(e.g.,
NO2
declined
34%
2020
vs.
2019),
confirming
model
reliability.
Transfer
learning
further
refined
accuracy,
reducing
RMSE
32–44%
across
when
benchmarked
real-world
data.
Notable
declines
Beijing
(42%),
Changchun
(38%),
Wuhan
(36%),
primarily
due
decreased
vehicular
traffic
industrial
activity.
Despite
occasional
anomalies
caused
localized
events
such
as
fireworks
(Beijing,
February
2020)
agricultural
burning
(Changchun,
April
2020),
our
findings
highlight
strong
influence
urban
quality.
These
results
offer
valuable
insights
for
designing
long-term
pollution
mitigation
strategies
policies.
Language: Английский
Air pollution and safety incidents: a Health policy case study with property and violent incidents in Medellín, Colombia, 2017–2019
International Journal of Urban Sustainable Development,
Journal Year:
2025,
Volume and Issue:
17(1), P. 20 - 43
Published: Jan. 30, 2025
Language: Английский
Air Quality Responses to Lockdowns in China Cities: Insights from Additive Model and Transfer Learning
Yuchen Ji,
No information about this author
Xiaonan Zhang,
No information about this author
Yueqian Cao
No information about this author
et al.
Authorea (Authorea),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 5, 2024
The
impact
of
the
COVID-19
lockdown
on
air
quality
in
seven
major
Chinese
cities
was
investigated
by
utilizing
long-term
datasets
pollutants
and
meteorological
conditions
from
2016
to
2021.
Generalized
additive
model
(GAM)
developed
predict
during
period.
accounting
for
weather
demonstrated
high
accuracy
with
predictions
compared
against
measurements
lockdown.
Significant
reductions
NO₂,
CO,
PM₁₀
concentrations
were
observed
primarily
due
decreased
vehicular
traffic
industrial
activities.
Notable
particularly
evident
volumes
emissions
prior
study
also
employed
transfer
learning
enhance
limited
data.
Despite
occasional
anomalies
caused
specific
events
like
fireworks
agricultural
burning,
findings
suggest
that
extended
training
periods
advanced
modeling
techniques
can
significantly
improve
predictions.
This
research
highlights
potential
benefits
sustained
human
activities
provides
valuable
insights
future
management
policy-making.
Language: Английский