Circular RNA circ_0004470 accelerates the occurrence of lung cancer by promoting DNA damage and cell cycle arrest

Journal of Biological Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 108456 - 108456

Published: March 1, 2025

Defects in the DNA damage response (DDR) are associated with tumorigenesis, and circular RNAs (circRNAs) can also affect occurrence progression of cancer by regulating gene expression. However, relationship between lung circRNAs remains unexplored. In this study, circ_0004470 was significantly upregulated various cells (H446, A549, H1299) as well carcinogenic animal models clinical samples. Circ_0004470 promoted cell cycle S phase arrest human pulmonary bronchial epithelial cells, inhibited repair, accelerated malignant transformation to continuous damage-inducing stimulation. repair binding specifically nucleotide excision complex XPC damage-specific protein 1 (DDB1), thus interacting process accelerating accumulation damage. These findings suggest that involved genetic damage-associated provide insight into mechanism which affects DDR during carcinogenesis.

Language: Английский

Organ-specific lithium accumulation and its toxic effects on female reproduction

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: unknown, P. 138516 - 138516

Published: May 1, 2025

Language: Английский