Heavy Metal–Gut Microbiota Interactions: Probiotics Modulation and Biosensors Detection

Biosensors, Journal Year: 2025, Volume and Issue: 15(3), P. 188 - 188

Published: March 14, 2025

This study provides a comprehensive analysis of the complex interaction between heavy metals (HMs) and gut microbiota, adopting bidirectional approach that explores both influence HMs on microbiota populations potential role probiotics in modulating these changes. By examining interconnected aspects, aims to offer deeper understanding how disrupt microbial balance probiotic interventions may mitigate or reverse effects, promoting detoxification processes overall health. In addition, review highlights innovative tools, such as biosensors, for rapid, precise, non-invasive detection urine. These advanced technologies enable real-time monitoring effectiveness probiotic-based interventions, offering critical insights into their elimination from body improving detoxification.

Language: Английский

Preparation Process Optimization of Glycolipids from Dendrobium officinale and the Difference in Antioxidant Effects Compared with Ascorbic Acid

Nutrients, Journal Year: 2024, Volume and Issue: 16(21), P. 3664 - 3664

Published: Oct. 28, 2024

Background:Dendrobium officinale glycolipids (DOG), often left as residues after hot water extraction for polysaccharide production, are discarded. Methods: This study investigates the optimal of DOG using response surface methodology, focusing on liquid–solid ratios, ethanol concentrations, temperatures, and times, while preliminarily analyzing DOG’s structural properties. Additionally, differences in antioxidant effects between ascorbic acid based intestinal flora metabolism were further evaluated. Results: The parameters determined follows: ratio 20 mL/g, concentration 70%, temperature 70 °C, time 2.5 h, yielding 2.64 ± 0.18%. In addition, was identified a diglyceride, mainly composed glucose, mannose, linoleic acid, 9,12,15-octadecatrienoic presented certain direct free radicals scavenging effects. animal experiments, unlike increased Bacteroides acidifaciens abundance mice, up-regulated piceatannol expression, down-regulated 1-naphthol which contributed to by enhancing activities SOD GSH-Px reducing MDA content. Conclusions: diglyceride isolated from D. extraction, strong regulating metabolism. These findings could promote efficient utilization support development functional food applications.

Language: Английский