Carbapenem-Resistant Pseudomonas aeruginosa’s Resistome: Pan-Genomic Plasticity, the Impact of Transposable Elements and Jumping Genes

Antibiotics, Journal Year: 2025, Volume and Issue: 14(4), P. 353 - 353

Published: March 31, 2025

Pseudomonas aeruginosa, a Gram-negative, motile bacterium, may cause significant infections in both community and hospital settings, leading to substantial morbidity mortality. This opportunistic pathogen can thrive various environments, making it public health concern worldwide. P. aeruginosa’s genomic pool is highly dynamic diverse, with pan-genome size ranging from 5.5 7.76 Mbp. versatility arises its ability acquire genes through horizontal gene transfer (HGT) via different genetic elements (GEs), such as mobile (MGEs). These MGEs, collectively known the mobilome, facilitate spread of encoding resistance antimicrobials (ARGs), heavy metals (HMRGs), virulence (VGs), metabolic functions (MGs). Of particular are acquired carbapenemase (ACGs) other β-lactamase genes, classes A, B [metallo-β-lactamases (MBLs)], D carbapenemases, which lead increased antimicrobial resistance. review emphasizes importance mobilome understanding aeruginosa.

Language: Английский

Alterations in microbial communities and antibiotic resistance genes pre- and post-sludge bulking in a wastewater treatment plant

Environmental Pollution, Journal Year: 2025, Volume and Issue: unknown, P. 126391 - 126391

Published: May 1, 2025

Language: Английский