Prenatal phthalate exposure and anogenital distance in infants at 12 months DOI Creative Commons
Kim N. Cajachagua‐Torres,

Nicole B. Salvi,

Eunsil Seok

et al.

Environment International, Journal Year: 2025, Volume and Issue: 199, P. 109472 - 109472

Published: April 15, 2025

Anogenital distance (AGD) is a postnatal marker of in utero exposure to androgens and anti-androgens, predictor reproductive health. We examined the association between gestational phthalates AGD male female infants. In 506 mother-infant pairs (276 males, 230 females), we measured urinary concentrations phthalate metabolites at < 18 18-25 weeks gestation child age 12.9 months (95 % range 11.4-21.1). Phthalate metabolite were adjusted for dilution, averaged, natural log-transformed. anus-clitoris (AGDac) anus-fourchette (AGDaf) females, anus-scrotum distance, anus-penis penile width males. used linear regression partial-linear single-index (PLSI) models examine associations as single pollutants mixture. Fifty-eight percent mothers Hispanic, followed by 27 non-Hispanic White. Higher exposures ∑di-isononyl(phthalate) (∑DiNP) was associated with longer AGDaf [1.28 mm confidence interval [CI]: 0.52, 2.03) 0.97 %CI: 0.25, 1.69), respectively]. ∑di(2-ethylhexyl)phthalate (∑DEHP) AGDac [2.80 1.17, 4.44), 1.90 0.76, 3.04), No observed males after multiple testing correction. mixture analyses, ∑DiNP ∑DEHP main contributors females. also detected an interaction Early pregnancy Biological mechanisms underlying these should be further investigated.

Language: Английский

Filling gaps in population estimates of phthalate exposure globally: A systematic review and meta-analysis of international biomonitoring data DOI Creative Commons

Jonathan M Acevedo,

Linda G. Kahn, Kristyn A. Pierce

et al.

International Journal of Hygiene and Environmental Health, Journal Year: 2025, Volume and Issue: 265, P. 114539 - 114539

Published: Feb. 14, 2025

Many phthalates have been identified as endocrine-disrupting chemicals because they alter hormone functions throughout the lifespan. Nationally representative biomonitoring data are available from United States, Canada, and Europe, but elsewhere sparse, making extrapolations of related disease disability burdens difficult. We therefore examined trends in urinary phthalate metabolite concentrations non-occupationally exposed populations countries other than where already at country level. systematically reviewed studies published between 2000 2023 analyzed changes across time using mixed-effects meta-regression models with without a quadratic term for time. controlled region, age, pregnancy status, heterogeneity Cochran's Q-statistic I2 index. Our final analysis consisted 216 studies. Non-pregnant youth exhibited nearly 2.0-fold or greater difference concentration compared to pregnant adult populations. Phthalates significant regional differences had 10-fold higher Middle East South Asia regions. meta-regressions an exponential increase DBP exposure through MnBP internationally (beta: 0.65 ng/mL/year2) Eastern Pacific (EPA) 0.78 ng/mL/year2). Most DEHP DnOP metabolites significantly declined EPA, while MEP by 10.62 ng/mL Latin America 8.98 Africa over findings fill gaps set stage further attributable burden cost international levels, especially low- middle-income countries.

Language: Английский

Citations

1
Prenatal exposure to mixtures of phthalates and bisphenol A and eczema risk: findings in atopic and non-atopic children from the LiNA birth cohort DOI Creative Commons
Sergio Gómez-Olarte,

Stefan Röder,

Ulrike Rolle‐Kampczyk

et al.

Environmental Research, Journal Year: 2025, Volume and Issue: unknown, P. 121667 - 121667

Published: April 1, 2025

We investigated whether maternal exposure to phthalate and bisphenol A (BPA) mixtures is associated with eczema in children, as most studies have only addressed single chemical exposures. Nine metabolites BPA were quantified urine at gestational weeks 34-36 (n = 540) total, inhalant, food allergen-specific immunoglobulin (Ig)E levels (sx1, fx5) measured serum from 4-year-old children of the LiNA cohort 219). The association prenatal phthalates BPA, both mixed, IgE was assessed stratified by atopy status. Three independent statistical models adjusted for covariates used: logistic regression -also sex-stratified analysis-, weighted quantile sum (WQS) regression, Bayesian kernel machine (BKMR). Moreover, an silico toxicogenomic analysis conducted explore putative underlying mechanisms. showed that monobenzyl (MBzP; OR 2.64, 95% CI: 1.29-6.4) di-2-ethylhexyl (2.09, 1.1-4.32) significantly exclusively atopic boys. BKMR suggested a positive trend between values subgroup. In WQS model, mixture' effect on among significant (1.90, 1.80-2.01) MBzP (65.9%), monoethyl (13.3%), (10.9%) being main contributors, which jointly modulate antibody-mediated immunity inflammation gene pathways profiling. Maternal differentially impacts risk atopy-stratified children. chemical-gene interaction identified genes involved immune cell activation Ig production. Compared non-atopic individual boys, suggesting chemicals may larger size predisposed populations.

Language: Английский

Citations

0
Chemical Prioritisation for Human Biomonitoring in Ireland: A Synergy of Global Frameworks and Local Perspectives DOI Creative Commons

Richa Singh,

Holger M. Koch, Marike Kolossa‐Gehring

et al.

Toxics, Journal Year: 2025, Volume and Issue: 13(4), P. 281 - 281

Published: April 7, 2025

Human biomonitoring (HBM) is a critical scientific tool for assessing human exposure by quantifying chemicals and their metabolites in biological specimens such as blood urine. This approach provides comprehensive accurate evaluation of internal exposures from diverse sources routes. In Ireland, establishing national HBM programme requires systematic chemical prioritisation process that aligns global frameworks with local public perceptions. study integrates insights international initiatives the European Joint Programme Biomonitoring Europe (HBM4EU) Partnership Assessment Risks Chemicals (PARC)—along programmes EU countries (Germany, France, Belgium, Norway, Slovenia, Czech Republic, Sweden) non-EU (US, Canada, South Korea, China, New Zealand). addition, survey was conducted to capture perceptions people Ireland regarding concern develop priority list biomarkers. The broader groups identified include heavy metals (lead, cadmium, mercury, arsenic, chromium VI), plasticisers (phthalates), bisphenols, pesticides, flame retardants, PFASs (per- polyfluoroalkyl substances), PAHs (polycyclic aromatic hydrocarbons), POPs (persistent organic compounds), VOCs (volatile UV (ultraviolet) filters. integrated, participatory roadmap robust, adaptable supports evidence-based policy decisions enhances health outcomes.

Language: Английский

Citations

0
Emerging contaminants in the Mediterranean Sea endangering Lebanon's Palm Islands Natural Reserve DOI Creative Commons
Bilal Nehmeh, Fatima Haydous, Hassan Ali

et al.

RSC Advances, Journal Year: 2025, Volume and Issue: 15(3), P. 2034 - 2044

Published: Jan. 1, 2025

This study investigates heavy metals and phthalates in water sediments of the Palm Islands Reserve, revealing persistent contamination, with cadmium exceeding limits. The findings underscore pollution control environmental monitoring.

Language: Английский

Citations

0
Plasticizer sources and concentrations in indoor environments in Europe: A systematic review of existing data DOI Creative Commons
Wenjuan Wei,

Aya Mansouri,

Sebastiaan L Zoutendijk

et al.

The Science of The Total Environment, Journal Year: 2025, Volume and Issue: 972, P. 179080 - 179080

Published: March 14, 2025

Language: Английский

Citations

0
Assessing the exposure to the UV filter DHHB in urine samples from the German Environmental Specimen Bank (2000–2021): Evaluating the impact of a potential impurity of di-n-hexyl phthalate in DHHB DOI Creative Commons
Max Scherer, Gerhard Scherer,

Kirsten Riedel

et al.

International Journal of Hygiene and Environmental Health, Journal Year: 2025, Volume and Issue: 266, P. 114565 - 114565

Published: March 21, 2025

Language: Английский

Citations

0
Prenatal phthalate exposure and anogenital distance in infants at 12 months DOI Creative Commons
Kim N. Cajachagua‐Torres,

Nicole B. Salvi,

Eunsil Seok

et al.

Environment International, Journal Year: 2025, Volume and Issue: 199, P. 109472 - 109472

Published: April 15, 2025

Anogenital distance (AGD) is a postnatal marker of in utero exposure to androgens and anti-androgens, predictor reproductive health. We examined the association between gestational phthalates AGD male female infants. In 506 mother-infant pairs (276 males, 230 females), we measured urinary concentrations phthalate metabolites at < 18 18-25 weeks gestation child age 12.9 months (95 % range 11.4-21.1). Phthalate metabolite were adjusted for dilution, averaged, natural log-transformed. anus-clitoris (AGDac) anus-fourchette (AGDaf) females, anus-scrotum distance, anus-penis penile width males. used linear regression partial-linear single-index (PLSI) models examine associations as single pollutants mixture. Fifty-eight percent mothers Hispanic, followed by 27 non-Hispanic White. Higher exposures ∑di-isononyl(phthalate) (∑DiNP) was associated with longer AGDaf [1.28 mm confidence interval [CI]: 0.52, 2.03) 0.97 %CI: 0.25, 1.69), respectively]. ∑di(2-ethylhexyl)phthalate (∑DEHP) AGDac [2.80 1.17, 4.44), 1.90 0.76, 3.04), No observed males after multiple testing correction. mixture analyses, ∑DiNP ∑DEHP main contributors females. also detected an interaction Early pregnancy Biological mechanisms underlying these should be further investigated.

Language: Английский

Citations

0