Chemical risk assessment in food animals via physiologically based pharmacokinetic modeling – Part II: Environmental pollutants on animal and human health assessments DOI Creative Commons
Kun Mi, Zhoumeng Lin

Environment International, Journal Year: 2025, Volume and Issue: unknown, P. 109372 - 109372

Published: March 1, 2025

Human activities generate a large amount of environmental pollutants, including drugs and agricultural industrial chemicals that are released into the air, water, soil. Environmental pollutants can enter food animals through contaminated feed posing risks to human health via chain. Physiologically based pharmacokinetic (PBPK) modeling is used predict target organ dosimetry informing risk assessment. However, there lack critical reviews concerning PBPK models for in last several years (2020-2024). This review part series focusing on applications inform safety assessments. Part I focused veterinary drugs. The present article II focuses chemicals, pesticides, polychlorinated biphenyls (PCBs), bisphenols, per- polyfluoroalkyl substances (PFAS). discusses existing challenges developing shares our perspectives future directions, combinations vitro vivo extrapolation (IVIVE), machine learning artificial intelligence, read-across approaches, quantitative pharmacodynamic enhance potential assessing safety.

Language: Английский

Chemical risk assessment in food animals via physiologically based pharmacokinetic modeling − Part I: Veterinary drugs on human food safety assessment DOI Creative Commons
Kun Mi, Xue Wu, Zhoumeng Lin

et al.

Environment International, Journal Year: 2025, Volume and Issue: 197, P. 109339 - 109339

Published: Feb. 18, 2025

Language: Английский

Citations

2
Chemical risk assessment in food animals via physiologically based pharmacokinetic modeling – Part II: Environmental pollutants on animal and human health assessments DOI Creative Commons
Kun Mi, Zhoumeng Lin

Environment International, Journal Year: 2025, Volume and Issue: unknown, P. 109372 - 109372

Published: March 1, 2025

Human activities generate a large amount of environmental pollutants, including drugs and agricultural industrial chemicals that are released into the air, water, soil. Environmental pollutants can enter food animals through contaminated feed posing risks to human health via chain. Physiologically based pharmacokinetic (PBPK) modeling is used predict target organ dosimetry informing risk assessment. However, there lack critical reviews concerning PBPK models for in last several years (2020-2024). This review part series focusing on applications inform safety assessments. Part I focused veterinary drugs. The present article II focuses chemicals, pesticides, polychlorinated biphenyls (PCBs), bisphenols, per- polyfluoroalkyl substances (PFAS). discusses existing challenges developing shares our perspectives future directions, combinations vitro vivo extrapolation (IVIVE), machine learning artificial intelligence, read-across approaches, quantitative pharmacodynamic enhance potential assessing safety.

Language: Английский

Citations

0