Published: Jan. 1, 2025
Language: Английский
Human Reproduction, Journal Year: 2025, Volume and Issue: unknown
Published: March 31, 2025
Abstract STUDY QUESTION What is the association between endometriosis and type age of menopause? SUMMARY ANSWER Women with had a 7-fold increased risk undergoing surgical menopause rather than natural were more likely to experience premature or early menopause, both surgically naturally. WHAT IS KNOWN ALREADY Endometriosis associated reduced ovarian reserve, but evidence on its relationship (surgical vs natural) timing (especially menopause) limited. are undergo hysterectomy and/or oophorectomy (either unilateral bilateral), average these surgeries remains unclear. DESIGN, SIZE, DURATION The study analysed individual-level data from 279 948 women in five cohort studies conducted UK, Australia, Sweden, Japan 1996 2022. PARTICIPANTS/MATERIALS, SETTING, METHODS whose could not be determined due premenopausal preservation use menopausal hormone therapy excluded. was identified through self-reports administrative data. Surgical defined as bilateral oophorectomy. Fine–Gray subdistribution hazard models estimated ratios (HRs) for menopause. Age at by ages final menstrual period Linear regression assessed mean differences age, while multinomial logistic odds (ORs) categorical age: <40 (premature), 40–44 (early), 45–49, 50–51 (reference), 52–54, ≥55 years. Spontaneous insufficiency (POI) before 40 MAIN RESULTS AND THE ROLE OF CHANCE 3.7% women. By end follow-up, 7.9% 58.2% experienced Using competing model, (HR: 7.54, 95% CI 6.84, 8.32) less 0.40, 0.33, 0.49). On average, occurred 1.6 years (19 months) earlier (β: −1.59, −1.77, −1.42) endometriosis. Among who it 0.4 (5 −0.37, −0.46, −0.28) those twice (<40 years) (OR: 2.11, 2.02, 2.20) 1.4 times develop spontaneous POI 1.36, 1.17, 1.59). They also (40–44 years). LIMITATIONS, REASONS FOR CAUTION This differentiate subtypes stages assess treatments endometrioma, which may impact reserve. Self-reported introduce recall bias. WIDER IMPLICATIONS FINDINGS Given consistent findings across individual studies, our results generalizable different populations, highlighting need tailored management prevent medically induced Long-term monitoring recommended, given their elevated adverse health outcomes later life. FUNDING/COMPETING INTEREST(S) InterLACE Consortium funded Australian National Health Medical Research Council project grant (APP1027196) Centres Excellence (APP1153420). G.D.M. Leadership Fellowship (APP2009577). research part Society Promotion Science (JSPS KAKENHI: 19KK0235, 23KK0167). authors have no conflict interest. Where personnel International Agency Cancer WHO, alone responsible views expressed this article, they do necessarily represent decisions, policy, WHO. TRIAL REGISTRATION NUMBER N/A.
Language: Английский
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Chinese Journal of Chromatography, Journal Year: 2025, Volume and Issue: 43(1), P. 60 - 67
Published: Jan. 1, 2025
Phthalates (PAEs) are endocrine-disrupting chemicals that widely present in everyday life and enter the human body through various pathways. The release of PAEs into environment pathways include leaching, evaporation, abrasion, use personal care products exposes humans to via ingestion, inhalation, dermal absorption. Pregnant women, as a particularly vulnerable population, risk adverse newborn growth development when exposed PAEs. While concentrations urine reflect recent exposure levels humans, urinary phthalate metabolites (mPAEs) commonly used biomarkers internal owing relatively short biological half-lives (<24 h). In this study, we developed solid-phase extraction-high performance liquid chromatography-tandem mass spectrometry (SPE-HPLC-MS/MS) method for simultaneously detecting eight mPAEs pregnant women. Urine samples were enzymatically hydrolyzed with β-glucosidase then purified using Bond Elut Plexa SPE column, subsequent elution, concentration, redissolved performed prior HPLC-MS/MS. Separation was achieved an Agilent Eclipse Plus C18 column (100 mm×3 mm, 3.5 μm), gradient elution 0.1% acetic acid aqueous solution acetonitrile mobile phases. Multiple reaction monitoring (MRM) mode detection, quantification internal-standard method. Good linearities obtained range 0.1-200 ng/mL mPAEs, limits detection (LODs) (LOQs) 0.015-0.048 0.050-0.160 ng/mL, respectively. exhibited recoveries 80.2%-99.7% at three spiked (1, 10, 50 ng/mL). This subsequently analyze 497 women from Ezhou Maternity Child Health Care Hospital. participants widespread PAEs, monobutyl (MBP) showing highest median level 104.46 monobenzyl (MBzP) lowest (0.22 addition, study assessed neonatal birth outcomes. Linear regression modeling revealed gestational age decreased by 0.11 weeks (95% confidence interval (CI): -0.18--0.03) every natural-log (ln) increase monoethyl (MEP) woman. Moreover, weight 39.28 g CI: -76.48--2.09) 39.62 -73.73--5.52), ln mono(2-ethyl-5-oxohexyl) (MEOHP) mono(2-ethylhexyl) (MECPP) levels, is characterized its simplicity, low LODs, high accuracy, precision. provides clear evidence PAE during pregnancy negatively affects measuring linking these findings Further large-scale cohort studies needed validate findings, along mechanistic animal models or in-vitro systems elucidate which contribute
Language: Английский
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Asian Pacific Journal of Reproduction, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 10, 2025
Objective: To investigate the potential of ascorbic acid in mitigating reproductive toxicity induced by di-(2-ethyl hexyl) phthalate (DEHP) female Wistar rats, focusing on oxidative stress, hormone levels, and gonadotropin receptors expression. Methods: Forty rats [30 days old, weighing (60±10)g] were randomly divided into five groups ( n =8 per group). Group 1 received corn oil (control). Groups 2 3 administered DEHP at 10 100 mg/kg body weight (b.wt.), respectively. 4 5 mg/ kg b.wt., respectively, plus b.wt.. All treatments given orally for 30 days. Blood ovarian tissues collected to assess serum hormones, receptor gene expression, stress markers, apoptosis. Results: DEHP, particularly higher dose, significantly decreased levels (follicle-stimulating hormone, luteinizing estradiol) expression (FSHR, LHR), while increasing Co-treatment with improved these parameters, reducing apoptosis, restoring Histopathology revealed fewer atretic follicles less disruption structure acid-treated compared those treated alone. Conclusions: Ascorbic demonstrates protective effects against DEHP-induced likely through normalizing function.
Language: Английский
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Seminars in Reproductive Medicine, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 29, 2025
Female reproductive aging often affects women's emotional, physical, and physiological well-being. Ovarian is characterized by fluctuations in hormones determines the age at which menopause occurs. Understanding potentially modifiable factors that influence this process essential for addressing health disparities, improving quality of life, informing relevant public strategies. This review synthesizes vivo, vitro, epidemiological findings about effects endocrine-disrupting chemicals (EDCs), specifically heavy metals perfluoroalkyl polyfluoroalkyl substances (PFAS) on female aging. Most vivo vitro studies have demonstrated alter ovarian morphology, folliculogenesis, steroidogenesis. Evidence regarding PFAS limited inconsistent. Epidemiological consistently shown are associated with a higher risk diminished reserve (indicated decreased anti-Müllerian hormone) earlier menopause, hormone changes. exposure has been estradiol but not significantly reserve. Gaps literature require more comprehensive research EDCs aging, including reserve, vasomotor symptoms, to inform future interventions reduce hazardous exposures improve health.
Language: Английский
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Published: Jan. 1, 2025
Language: Английский
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