Journal of Agricultural and Food Chemistry,
Journal Year:
2023,
Volume and Issue:
71(31), P. 12043 - 12051
Published: July 20, 2023
Cadmium
is
highly
toxic
and
present
in
the
environment
can
be
accumulated
among
various
levels
of
food
chain.
Both
humans
animals
are
at
risk
from
toxicity
associated
with
cadmium.
However,
neurological
endpoint
caused
by
cadmium
has
not
been
revealed.
The
aim
our
research
to
explore
potential
target
attack
when
causing
neurotoxicity.
80
male
chickens
(one
day
old,
weighing
36.49
±
2.88
g)
were
randomly
divided
into
four
groups
independently
treated
0,
35,
70,
or
140
mg/kg
CdCl2
diet
for
90
days.
result
showed
that
striatum
was
damaged
due
a
high
dose
brain,
which
characterized
degeneration
neurons
astrocyte
dysfunction.
Transcriptome
analysis
demonstrated
striatal
astrocytes
transformed
A1
state
under
exposure.
Deeper
investigation
revealed
internalization
gap
junction
protein
connexin
43
responsible
this
transformation.
Eventually,
we
conclude
internalized
anchoring,
process
accompanied
transformation
subtype.
This
study
provides
new
direction
exploring
effects
on
nervous
system
treatment
subsequent
diseases.
Journal of Agricultural and Food Chemistry,
Journal Year:
2023,
Volume and Issue:
71(5), P. 2579 - 2589
Published: Jan. 25, 2023
Phthalates
are
widely
used
to
improve
the
flexibility
of
poly(vinyl
chloride)
(PVC)
polymer
agriculture
products.
Di(2-ethylhexyl)
phthalate
(DEHP)
is
a
type
addition
plastic
and
can
lead
many
health
problems.
Hemeoxygenase-1
(HO-1)
an
extremely
important
molecule
that
releases
enzymatic
products
promote
ferroptosis.
This
research
aimed
explore
function
HO-1
in
DEHP-induced
renal
proximal
tubule
cell
In
experiment,
ICR
male
mice
exposed
(0,
50,
200,
500
mg/kg
BW/day)
DEHP
for
28
days.
Here,
we
observed
induced
glomeruli
atrophy
tubules
swell.
Furthermore,
exposure
could
increase
ferrous
iron
content
decrease
antioxidant
activity.
We
also
found
increased
expression
nuclear
factor-erythroid
2
p45-related
factor
(NFE2L2)
nucleus.
particular,
significantly
both
protein
mRNA
levels.
Glutathione
peroxidase
4
(GPX4)
as
endogenous
control
ferroptosis
was
downregulated,
which
proved
occurrence
study,
activated
NFE2L2/HO-1
signaling
pathway
resulted
tubule.
connects
with
HO-1,
providing
new
insights
into
potential
roles
phthalates
nephrotoxicity.
The
accumulation
of
senescent
cells
in
kidneys
is
considered
to
contribute
age-related
diseases
and
organismal
aging.
Mitochondria
are
a
regulator
cell
senescence
process.
Atrazine
as
triazine
herbicide
poses
threat
renal
health
by
disrupting
mitochondrial
homeostasis.
Melatonin
plays
critical
role
maintaining
present
study
aims
explore
the
mechanism
which
melatonin
alleviates
atrazine-induced
injury
whether
parkin-mediated
mitophagy
contributes
mitigating
senescence.
found
that
level
parkin
was
decreased
after
atrazine
exposure
negatively
correlated
with
markers.
treatment
increased
serum
levels
mitigates
tubular
epithelial
Mechanistically,
maintains
integrity
crista
structure
increasing
contact
site
cristae
organizing
system,
transcription
factor
A
(TFAM),
adenosine
triphosphatase
family
AAA
domain-containing
protein
3A
(ATAD3A),
sorting
assembly
machinery
50
(Sam50)
prevent
DNA
release
subsequent
activation
cyclic
guanosine
5′-monophosphate–adenosine
5′-monophosphate
synthase
pathway.
Furthermore,
activates
Sirtuin
3–superoxide
dismutase
2
axis
eliminate
reactive
oxygen
species
kidney.
More
importantly,
antisenescence
largely
determined
parkin-dependent
mitophagy.
These
results
offer
novel
insights
into
measures
against
Parkin-mediated
promising
drug
target
for
alleviating
Journal of Agricultural and Food Chemistry,
Journal Year:
2023,
Volume and Issue:
71(44), P. 16727 - 16738
Published: Oct. 23, 2023
Di-(2-ethylhexyl)
phthalate
(DEHP)
is
frequently
used
as
a
plasticizer
in
industrial
and
agricultural
products.
DEHP
can
cause
severe
neurotoxicity,
such
impaired
learning
memory
function.
Lycopene
(LYC)
carotenoid
exerts
excellent
antioxidant
capacity
therapeutic
effects
neurodegenerative
diseases.
However,
whether
LYC
prevent
the
cognitive
impairment
induced
by
specific
mechanisms
are
unclear.
In
present
study,
behavioral
test
results
suggested
that
alleviated
DEHP.
The
histopathological
data
revealed
attenuated
DEHP-induced
disordered
arrangement
of
neurons
CA1
CA3
regions
hippocampus
tissue.
Moreover,
inhibited
occurrence
ferroptosis
via
regulating
iron
metabolism,
inhibiting
lipid
peroxidation,
activating
cysteine
transporter
nuclear
factor
erythroid
2-related
2/heme
oxygenase-1
(NrF2/HO-1)
signaling
pathway.
Overall,
study
contributes
novel
perspectives
into
potential
preventing
phthalate-induced
hippocampus.
Journal of Agricultural and Food Chemistry,
Journal Year:
2024,
Volume and Issue:
72(30), P. 16998 - 17007
Published: July 17, 2024
Butachlor
is
widely
used
in
agriculture
around
the
world
and
therefore
poses
environmental
public
health
hazards
due
to
persistent
poor
biodegradability.
Ferroptosis
a
type
of
iron-mediated
cell
death
controlled
by
glutathione
(GSH)
GPX4
inhibition.
P62
an
essential
autophagy
adaptor
that
regulates
Keap1
activate
nuclear
factor
erythroid
2-related
2
(Nrf2),
which
effectively
suppresses
lipid
peroxidation,
thereby
relieving
ferroptosis.
Here,
we
found
butachlor
caused
changes
splenic
macrophage
structure,
especially
impaired
mitochondrial
morphology
with
disordered
suggestive
occurrence
This
was
further
confirmed
detection
iron
metabolism,
GSH
system,
peroxidation.
Mechanistically,
suppressed
protein
level
p62
promoted
Keap1-mediated
degradation
Nrf2,
results
decreased
expression
accelerated
These
findings
suggest
targeting
p62-Nrf2-GPX4
signaling
axis
may
be
promising
strategy
for
treating
inflammatory
diseases.
Journal of Advanced Research,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 1, 2024
Environmental
and
occupational
exposure
to
cadmium
(Cd)
has
been
shown
cause
acute
kidney
injury
(AKI).
Previous
studies
have
demonstrated
that
autophagy
inhibition
lysosomal
dysfunction
are
important
mechanisms
of
Cd-induced
AKI.
Transcription
factor
EB
(TFEB)
is
a
critical
transcription
regulator
modulates
autophagy-lysosome
function,
but
its
role
in
AKI
yet
be
elucidated.
Thus,
vivo
vitro
were
conducted
clarify
this
issue.
Data
firstly
showed
reduced
TFEB
expression
nuclear
translocation
evident
models,
accompanied
by
dysfunction.
Pharmacological
genetic
activation
improved
via
alleviating
dysfunction,
whereas
Tfeb
knockdown
further
aggravated
phenomenon,
suggesting
the
key
regulating
autophagy.
Mechanistically,
Cd
activated
mechanistic
target
rapamycin
complex
1
(mTORC1)
enhance
phosphorylation
thereby
inhibiting
translocation.
also
chromosome
region
maintenance
(CRM1)
promote
export.
Meanwhile,
general
control
non-repressed
protein
5
(GCN5)
acetylation,
resulting
decreased
transcriptional
activity.
Moreover,
CRM1
or
GCN5
alleviated
enhancing
activity,
respectively.
In
summary,
these
findings
reveal
phosphorylation,
export
acetylation
independently
suppress
activity
might
promising
treatment
strategy
for
Journal of Agricultural and Food Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 25, 2025
Di(2-ethylhexyl)
phthalate
(DEHP),
which
is
widely
used
in
agricultural
plastics,
accumulates
humans
and
animals
through
the
food
chain
over
time,
resulting
liver
toxicity.
Recent
studies
have
reported
that
pyroptosis
mitochondrial
damage
are
closely
related
to
a
variety
of
diseases,
but
specific
mechanism
still
unclear.
To
address
this
issue,
vitro
vivo
hepatotoxicity
models
were
established.
The
results
demonstrated
exposure
DEHP
caused
buildup
MEHP
livers,
altered
metabolite
composition,
pyroptosis-like
changes
hepatocytes.
After
treatment,
REDOX
homeostasis
was
unbalanced,
reactive
oxygen
species
(mtROS)
overproduced.
activates
mediated
by
TNF/TNFR1
signaling
upregulates
perforating
protein
GSDMD-N
destroy
membrane
Above
all,
study
elucidates
potential
involvement
signaling-mediated
confirms
regulation
helpful
maintaining
normal
function.
