Cadmium Transforms Astrocytes into the A1 Subtype via Inducing Gap Junction Protein Connexin 43 into the Nucleus DOI
Yingxin Zhao,

Xue‐Nan Li,

Yi-Xi Tang

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2023, Volume and Issue: 71(31), P. 12043 - 12051

Published: July 20, 2023

Cadmium is highly toxic and present in the environment can be accumulated among various levels of food chain. Both humans animals are at risk from toxicity associated with cadmium. However, neurological endpoint caused by cadmium has not been revealed. The aim our research to explore potential target attack when causing neurotoxicity. 80 male chickens (one day old, weighing 36.49 ± 2.88 g) were randomly divided into four groups independently treated 0, 35, 70, or 140 mg/kg CdCl2 diet for 90 days. result showed that striatum was damaged due a high dose brain, which characterized degeneration neurons astrocyte dysfunction. Transcriptome analysis demonstrated striatal astrocytes transformed A1 state under exposure. Deeper investigation revealed internalization gap junction protein connexin 43 responsible this transformation. Eventually, we conclude internalized anchoring, process accompanied transformation subtype. This study provides new direction exploring effects on nervous system treatment subsequent diseases.

Language: Английский

Evaluation of phthalates induced cardiotoxicity using human iPSCs-derived cardiomyocyte and dual-cardiotoxicity evaluation methods DOI
Seulgi Lee,

Yoonseo Kim,

Sang Woong Park

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 296, P. 118196 - 118196

Published: April 21, 2025

Language: Английский

Citations

0
Effect of particle size and environmental conditions on the release of di(2-ethylhexyl) phthalate from microplastics DOI
Shaohua Mao,

Chiquan He

Chemosphere, Journal Year: 2023, Volume and Issue: 345, P. 140474 - 140474

Published: Oct. 19, 2023

Language: Английский

Citations

10
Ca2+ homeostasis imbalance induced by Pparg: A key factor in di (2-ethylhexyl) phthalate (DEHP)-induced cardiac dysfunction in zebrafish larvae DOI
Yang Yang, Yue Tao,

Rongyi Yang

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: unknown, P. 170436 - 170436

Published: Jan. 1, 2024

Language: Английский

Citations

3
Crosstalk between aryl hydrocarbon receptor and Wnt/β-catenin signaling pathway: Possible culprit of di (2-ethylhexyl) phthalate-mediated cardiotoxicity in zebrafish larvae DOI
Yang Yang,

Yue Tao,

Xiaodong Yi

et al.

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 907, P. 167907 - 167907

Published: Oct. 20, 2023

Language: Английский

Citations

8
Cadmium Transforms Astrocytes into the A1 Subtype via Inducing Gap Junction Protein Connexin 43 into the Nucleus DOI
Yingxin Zhao,

Xue‐Nan Li,

Yi-Xi Tang

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2023, Volume and Issue: 71(31), P. 12043 - 12051

Published: July 20, 2023

Cadmium is highly toxic and present in the environment can be accumulated among various levels of food chain. Both humans animals are at risk from toxicity associated with cadmium. However, neurological endpoint caused by cadmium has not been revealed. The aim our research to explore potential target attack when causing neurotoxicity. 80 male chickens (one day old, weighing 36.49 ± 2.88 g) were randomly divided into four groups independently treated 0, 35, 70, or 140 mg/kg CdCl2 diet for 90 days. result showed that striatum was damaged due a high dose brain, which characterized degeneration neurons astrocyte dysfunction. Transcriptome analysis demonstrated striatal astrocytes transformed A1 state under exposure. Deeper investigation revealed internalization gap junction protein connexin 43 responsible this transformation. Eventually, we conclude internalized anchoring, process accompanied transformation subtype. This study provides new direction exploring effects on nervous system treatment subsequent diseases.

Language: Английский

Citations

7