The Interplay of the Mammalian Brain and Thyroid Hormones, and the Threat of Endocrine-Disrupting Chemicals

Endocrines, Journal Year: 2024, Volume and Issue: 5(4), P. 501 - 515

Published: Oct. 25, 2024

Introduction: During the formation of neural circuits, developing brain demonstrates extraordinary plasticity, heavily influenced by hormones. These chemical messengers interact with specific receptors to regulate vital physiological functions. The thyroid gland plays a pivotal role in maintaining hormonal balance and guiding development. However, emerging threats like endocrine-disrupting chemicals (EDCs) can interfere this intricate system. EDCs are exogenous substances that mimic, enhance, or block actions endogenous hormones, disrupting signaling at various developmental stages. Exposure impair cognitive function behavior due disruptions function. Studies indicate mixtures negatively impact development, leading lower IQ behavioral problems. Reducing EDC exposure through regulations public awareness is crucial, further research needed elucidate their mechanisms. Conclusions: Protecting vulnerable populations, such as pregnant women children, essential prompt regulatory measures.

Language: Английский

Effects of sub-chronic exposure to microcystin-LR on the endocrine system of male rats

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 906, P. 166839 - 166839

Published: Sept. 9, 2023

Language: Английский

Mediation of association between semen microcystin exposure and semen quality by sex hormones in Chinese men

Reproductive Toxicology, Journal Year: 2023, Volume and Issue: 124, P. 108529 - 108529

Published: Dec. 28, 2023

Language: Английский