Gut,
Journal Year:
2024,
Volume and Issue:
unknown, P. gutjnl - 332523
Published: Aug. 23, 2024
Epidemiological
and
translational
data
increasingly
implicate
environmental
pollutants
in
inflammatory
bowel
disease
(IBD).
Indeed,
the
global
incidence
of
IBD
has
been
rising,
particularly
developing
countries,
parallel
with
increased
use
chemicals
synthetic
materials
daily
life
escalating
pollution
levels.
Recent
nationwide
ecological
studies
have
reported
associations
between
agricultural
pesticides
IBD,
Crohn’s
disease.
Exposure
to
other
chemical
categories
also
linked
an
risk
IBD.
To
synthesise
available
identify
knowledge
gaps,
we
conducted
a
systematic
review
human
that
on
impact
outcomes.
Furthermore,
summarised
vitro
animal
investigating
mechanisms
underlying
these
associations.
The
32
included
corroborate
heavy
transition
metals,
except
zinc,
air
pollutants,
per-
polyfluorinated
substances,
are
associated
exposure
being
disease-related
adverse
outcomes
as
well.
narrative
preclinical
suggests
several
overlapping
associations,
including
intestinal
permeability,
systemic
inflammation
dysbiosis.
A
consolidated
understanding
exposures
is
key
identification
potentially
modifiable
factors
inform
strategies
towards
prediction,
prevention
mitigation
iMeta,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 18, 2025
Maternal
health,
specifically
changes
in
the
gut
microbiota,
can
profoundly
impact
offspring
health;
however,
our
understanding
of
how
microbiota
alterations
during
preconception
period
influence
remains
limited.
In
this
study,
we
investigated
and
mechanisms
maternal
dysbiosis
on
development
enteric
nervous
system
(ENS)
mice.
We
found
that
exposure
to
antibiotics
led
abnormal
ENS
offspring,
increasing
their
susceptibility
water
avoidance
stress
at
adult
stage.
Metagenomic,
targeted
metabolomic,
transcriptomic
analyses
revealed
antibiotic
disrupted
expression
genes
crucial
for
embryonic
by
altering
composition.
Multi-omics
analysis
combined
with
Limosilactobacillus
reuteri
propionate
gestational
supplementation
demonstrated
metabolites
may
via
GPR41-GDNF/RET/SOX10
signaling
pathway.
Our
findings
highlight
critical
importance
maintaining
a
healthy
before
conception
support
normal
offspring.
Reproductive Toxicology,
Journal Year:
2025,
Volume and Issue:
unknown, P. 108843 - 108843
Published: Feb. 1, 2025
Monascus
red
(MR)
is
widely
used
as
a
natural
food
colorant
and
preservative
in
East
Asia.
However,
the
potential
effects
of
MR
during
pregnancy
remains
unknown.
In
this
study,
was
administrated
to
Sprague-Dawley
(SD)
rats
at
doses
0,
0.50,
1.58,
5.00g/kg
bw
on
gestational
days
6-15
by
oral
gavage.
maternal
embryo-fetal
examinations,
there
were
no
marked
toxicities
terms
general
clinical
signs,
body
weight,
consumption,
serum
endocrine
indices,
organ
weights,
thyroid
histopathology,
examinations
uterine
contents
fetuses.
gut
microbiota
analysis,
dose
decreased
α
diversity
slightly
changed
their
community
structure
genus
level.
Yet
animals
or
development
observed.
The
no-observed-adverse-effect-level
(NOAEL)
developmental
toxicity
through
exposure
bw,
highest
tested
rats.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(6), P. 2648 - 2648
Published: March 14, 2025
Perfluorooctane
sulfonic
acid
(PFOS)
is
a
persistent
organic
pollutant
that
has
attracted
much
attention
due
to
its
wide
environmental
distribution
and
potential
toxicity.
Intestinal
microbiota
an
important
regulator
of
host
health,
composition
metabolic
function
are
easily
interfered
with
by
pollutants.
In
this
study,
the
effects
PFOS
exposure
on
gut
microbiota,
lipid
metabolism,
health
were
investigated
in
mice.
The
results
showed
did
not
significantly
change
α
diversity,
but
affected
β
diversity
community
structure
intestinal
microflora
At
taxonomic
level,
ratio
Firmicutes
Bacteroidetes
decreased,
changes
abundance
specific
bacteria
closely
related
liver
diseases
metabolism
disorders.
also
gut–liver
axis
mechanism,
increased
blood
lipids
indicators
mice,
induced
histological
lesions.
This
study
revealed
toxic
mechanism
mediated
providing
new
research
perspective
for
problems
caused
pollutants
theoretical
support
formulation
relevant
public
policies.
