Neurotoxicity from long-term exposure to 6-PPDQ: Recent advances DOI Creative Commons
Changsheng Ma,

Dong-Lun Li,

Fang Wang

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 282, P. 116689 - 116689

Published: July 15, 2024

The recent acceleration of industrialization and urbanization has brought significant attention to N-(1,3-Dimethylbutyl)-N'-phenyl-p-phenylenediamine quinone (6-PPDQ), an emerging environmental pollutant from tire wear, due its long-term effects on the environment organisms. Recent studies suggest that 6-PPDQ can disrupt neurotransmitter synthesis release, impact receptor function, alter signaling pathways, potentially causing oxidative stress, inflammation, apoptosis. This review investigates potential neurotoxic prolonged exposure, mechanisms underlying cytotoxicity, associated health risks. We emphasize need for future research, including precise exposure assessments, identification individual differences, development risk assessments intervention strategies. article provides a comprehensive overview 6-PPDQ's behavior, impact, neurotoxicity in environment, highlighting key areas challenges research.

Language: Английский

Exposure to 6-PPD quinone enhances glycogen accumulation in Caenorhabditis elegans DOI
Yuxing Wang, Dayong Wang

Environmental Pollution, Journal Year: 2024, Volume and Issue: 359, P. 124600 - 124600

Published: July 22, 2024

Language: Английский

Citations

9
Exposure to 6-PPD quinone disrupts glucose metabolism associated with lifespan reduction by affecting insulin and AMPK signals in Caenorhabditis elegans DOI
Zhenjun Liu, Yunhui Li, Dayong Wang

et al.

Chemosphere, Journal Year: 2024, Volume and Issue: 363, P. 142975 - 142975

Published: July 29, 2024

Language: Английский

Citations

9
Nanoplastic at environmentally relevant concentrations induces toxicity across multiple generations associated with inhibition in germline G protein-coupled receptor CED-1 in Caenorhabditis elegans DOI
Jingwei Wu, Yuting Shao,

Xin Hua

et al.

Chemosphere, Journal Year: 2024, Volume and Issue: 364, P. 143011 - 143011

Published: Aug. 3, 2024

Language: Английский

Citations

8
Comparison of Transgenerational Neurotoxicity between Pristine and Amino-Modified Nanoplastics in C. elegans DOI Creative Commons

Mingxuan Song,

Qinli Ruan, Dayong Wang

et al.

Toxics, Journal Year: 2024, Volume and Issue: 12(8), P. 555 - 555

Published: July 30, 2024

Increasing evidence has suggested that nanoplastic pollution become a global concern. More importantly, transgenerational toxicity can be induced by nanoplastics at predicted environmentally relevant doses (ERDs). Considering amino modification could increase toxicity, we compared neurotoxicity between pristine polystyrene nanoparticle (PS-NP) and amino-modified PS-NP (NH

Language: Английский

Citations

7
Neurotoxicity from long-term exposure to 6-PPDQ: Recent advances DOI Creative Commons
Changsheng Ma,

Dong-Lun Li,

Fang Wang

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 282, P. 116689 - 116689

Published: July 15, 2024

The recent acceleration of industrialization and urbanization has brought significant attention to N-(1,3-Dimethylbutyl)-N'-phenyl-p-phenylenediamine quinone (6-PPDQ), an emerging environmental pollutant from tire wear, due its long-term effects on the environment organisms. Recent studies suggest that 6-PPDQ can disrupt neurotransmitter synthesis release, impact receptor function, alter signaling pathways, potentially causing oxidative stress, inflammation, apoptosis. This review investigates potential neurotoxic prolonged exposure, mechanisms underlying cytotoxicity, associated health risks. We emphasize need for future research, including precise exposure assessments, identification individual differences, development risk assessments intervention strategies. article provides a comprehensive overview 6-PPDQ's behavior, impact, neurotoxicity in environment, highlighting key areas challenges research.

Language: Английский

Citations

5