In
this
study
the
adsorption
of
a
mixture
seven
pharmaceutical
compounds
on
virgin
and
aged
PET-microplastics
(MPs)
has
been
studied.
The
target
comprised
two
widely-used
anti-inflammatory
drugs,
diclofenac
(DCF)
ketoprofen
(KTF),
one
anti-hypertensive,
valsartan
(VLS),
four
common
antibiotics,
indomethacin
(IMC),
trimethoprim
(TMP),
isoniazid
(ISO),
metronidazole
(MTZ).
Regarding
MPs,
types
PET
(virgin
UV-aged)
were
used
in
experimental
procedure.
Kinetic
studies
conducted,
isomers
obtained
revealing
possible
interactions
that
take
place
between
adsorbents
adsorbates.
Among
studied
pharmaceuticals,
DCF
presents
highest
uptake
due
to
its
hydrophobic
nature,
while
aging
appears
induce
drugs
MPs.
Factors
like
pH
or
environmental
matrix
also
evaluated.
results
revealed
sorption
is
pH-dependent,
more
complicated
matrices
wastewater
seawater
exhibit
lower
than
distilled
water
natural
organic
matter
(NOM)
present
increased
salinity,
respectively.
Finally,
desorption
conducted
three
different
values
showing
higher
release
at
alkaline
pH.
was
for
followed
order
DCF>VLS>KTF>IMC>TMP>MTZ>ISO.
Biodegradable
plastics
(BPs)
are
promoted
as
eco-friendly
alternatives
to
conventional
plastics.
However,
compared
microplastics
(MPs),
they
degrade
rapidly
into
biodegradable
(BMPs),
which
may
lead
a
more
significant
accumulation
of
BMPs
in
the
environment.
This
review
systematically
compares
and
MPs,
summarizes
current
knowledge
on
their
environmental
behaviors
impacts
ecosystems
human
health,
offers
recommendations
for
future
research.
detected
water,
sediments,
indoor
dust,
food,
marine
organisms,
samples.
Compared
prone
transformations,
such
photodegradation
biodegradation,
results
shorter
migration
distance
across
different
matrices.
Like
can
adsorb
pollutants
transport
them
enhancing
toxicity
health
risks
through
Trojan
horse
effect.
Studies
indicate
that
negatively
impact
terrestrial
aquatic
than
MPs
by
disrupting
nutrient
cycling
inhibiting
plant
animal
growth.
In
vivo
vitro
research
also
shows
BMP
degradation
products
increase
bioavailability,
exacerbating
neurotoxicity
overall
toxicity.
findings
BMPs'
effects
remain
inconsistent.
Further
evaluation
trade-offs
between
biodegradability
is
needed
address
these
uncertainties.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(28)
Published: May 15, 2024
Biodegradable
plastics,
hailed
for
their
environmental
friendliness,
may
pose
unforeseen
risks
as
they
undergo
gastrointestinal
degradation,
forming
oligomer
nanoplastics.
Despite
this,
the
influence
of
degradation
on
potential
human
toxicity
biodegradable
plastics
remains
poorly
understood.
To
this
end,
impact
murine
in
vivo
digestive
system
is
investigated
biotransformation,
biodistribution,
and
PLA
polymer
MPs.
Through
a
28-day
repeated
oral
gavage
study
mice,
it
revealed
that
microplastics
incomplete
complete
respectively,
tract.
Incompletely
degraded
transform
into
nanoplastics,
heightening
bioavailability
toxicity,
thereby
exacerbating
overall
toxic
effects.
Conversely,
reduces
mitigates
offering
avenue
reduction.
Additionally,
illuminates
shared
targets
mechanisms
Parkinson's
disease-like
neurotoxicity
induced
by
both
microplastics.
This
involves
upregulation
MICU3
midbrains,
leading
to
neuronal
mitochondrial
calcium
overload.
Notably,
mitigated
inhibiting
influx
with
MCU-i4
or
facilitating
efflux
DBcAMP
mice.
These
findings
enhance
understanding
toxicological
implications
health.
