Recent advances in brain organoids: a comprehensive review of the last eight years DOI
Yuan Xiong, Ting‐Hua Wang

New discovery., Journal Year: 2024, Volume and Issue: unknown, P. 1 - 14

Published: Oct. 31, 2024

Organoids are three-dimensional cellular structures grown in vitro that can self-organize and differentiate into cell types with organ-specific functions, closely mimicking the biological properties of tissues organs vivo. Brain organoids, which resembling brain function, serve as valuable models for medical research, including disease microenvironment simulation, mechanism exploration, drug evaluation. In this review, we analyzed 808 articles retrieved from PubMed, CNKI, Wanfang databases using keyword "brain organoids," 180 were included. We summarized research progress organoids over past eight years by categorizing refining findings. Our analysis shows have achieved significant success simulating development vitro, leading to establishment refinement 3D organoid research. been widely applied explore disease-related mechanisms, yielding promising results opening avenues further on human brain. summarize three areas: culture methods, exploration.

Language: Английский

Engineering human midbrain organoid microphysiological systems to model prenatal PFOS exposure DOI

Chunhui Tian,

Hongwei Cai,

Zheng Ao

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 947, P. 174478 - 174478

Published: July 2, 2024

Language: Английский

Citations

5
The impact of emerging contaminants exposure on human health effects: A review of organoid assessment models DOI
Jingyi Yang, Xue Zhang, Zesheng Liu

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 498, P. 155882 - 155882

Published: Sept. 16, 2024

Language: Английский

Citations

5
Recent Advances in Graphene Oxide-Based on Organoid Culture as Disease Model and Cell Behavior – A Systematic Literature Review DOI Creative Commons
Haura Labibah Salsabil Sulaksono,

Annisa Annisa,

Rovina Ruslami

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 6201 - 6228

Published: June 1, 2024

Abstract: Due to their ability replicate the in vivo microenvironment through cell interaction and induce cells stimulate function, three-dimensional culture models can overcome limitations of two-dimensional models. Organoids are 3D that demonstrate natural structure an organ. In most organoid tissue cultures, matrigel made a mouse tumor extracellular matrix protein mixture is essential ingredient. However, its tumor-derived origin, batch-to-batch variation, high cost, safety concerns have limited usefulness drug development regenerative medicine. Its clinical application has also been hindered by fact generation dependent on use poorly defined matrices. Therefore, optimization crucial step developing introduces alternatives as different materials. Recently, variety substitute materials reportedly replaced matrigel. The purpose this study review significance latest advances for applications how they enhance build network systems generating proper behavior. Excellence behavior evaluated from characteristics, proliferation, differentiation, even gene expression. As result, graphene oxide demonstrated potency Graphene promote good well known having biocompatibility. Hence, provide opportunities future advanced Keywords: organoid, culture, graphene, matrigel, alternative behavior, host-pathogen

Language: Английский

Citations

4
Brain organoids-on-chip for neural diseases modeling: History, challenges and trends DOI Creative Commons
Hongyong Zhang, Nan Huang, Sumin Bian

et al.

Journal of Pharmaceutical Analysis, Journal Year: 2025, Volume and Issue: unknown, P. 101323 - 101323

Published: April 1, 2025

Language: Английский

Citations

0
High-quality models for assessing the effects of environmental pollutants on the nervous system: 3D brain organoids DOI Creative Commons

Yu Yan,

Ziye Yang, Liqun Chen

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 284, P. 116876 - 116876

Published: Aug. 14, 2024

The prevalence of environmental problems and the increasing risk human exposure to pollutants have become a global concern. pollution is one main reasons for rising incidence most neurological-related diseases in recent years. However, ethical constraints direct research racial limitations animal models slowed progress this area. purpose study review neurotoxicity different on brain using organoids as new model conclude that may play key role assessing mechanisms by which affect neurogenesis cause neurological pathogenesis. To accurately determine negative effects nervous system, self-organizing are highly similar developing system studying development disease. This uses summarize including structural changes organoids, inhibition neuronal differentiation migration, impairment mitochondrial function, damage cellular cilia, influence signaling pathways. In conclusion, system. Therefore, it crucial understand how use ameliorate disorders caused pollution.

Language: Английский

Citations

3
A multichannel microfluidic device for revealing the neurotoxic effects of Bisphenol S on cerebral organoids under low-dose constant exposure DOI
Aynur Abdulla,

Haoni Yan,

Shujin Chen

et al.

Biosensors and Bioelectronics, Journal Year: 2024, Volume and Issue: 267, P. 116754 - 116754

Published: Sept. 14, 2024

Language: Английский

Citations

3
hPSCs-derived brain organoids for disease modeling, toxicity testing and drug evaluation DOI
Na Xie, Jinrong Bai,

Ya Hou

et al.

Experimental Neurology, Journal Year: 2024, Volume and Issue: 385, P. 115110 - 115110

Published: Dec. 10, 2024

Language: Английский

Citations

1
The Interplay of the Mammalian Brain and Thyroid Hormones, and the Threat of Endocrine-Disrupting Chemicals DOI Creative Commons
Nuha A. Dsouki, Bruno Fiorelini Pereira, Regina H. Silva

et al.

Endocrines, Journal Year: 2024, Volume and Issue: 5(4), P. 501 - 515

Published: Oct. 25, 2024

Introduction: During the formation of neural circuits, developing brain demonstrates extraordinary plasticity, heavily influenced by hormones. These chemical messengers interact with specific receptors to regulate vital physiological functions. The thyroid gland plays a pivotal role in maintaining hormonal balance and guiding development. However, emerging threats like endocrine-disrupting chemicals (EDCs) can interfere this intricate system. EDCs are exogenous substances that mimic, enhance, or block actions endogenous hormones, disrupting signaling at various developmental stages. Exposure impair cognitive function behavior due disruptions function. Studies indicate mixtures negatively impact development, leading lower IQ behavioral problems. Reducing EDC exposure through regulations public awareness is crucial, further research needed elucidate their mechanisms. Conclusions: Protecting vulnerable populations, such as pregnant women children, essential prompt regulatory measures.

Language: Английский

Citations

0
Recent advances in brain organoids: a comprehensive review of the last eight years DOI
Yuan Xiong, Ting‐Hua Wang

New discovery., Journal Year: 2024, Volume and Issue: unknown, P. 1 - 14

Published: Oct. 31, 2024

Organoids are three-dimensional cellular structures grown in vitro that can self-organize and differentiate into cell types with organ-specific functions, closely mimicking the biological properties of tissues organs vivo. Brain organoids, which resembling brain function, serve as valuable models for medical research, including disease microenvironment simulation, mechanism exploration, drug evaluation. In this review, we analyzed 808 articles retrieved from PubMed, CNKI, Wanfang databases using keyword "brain organoids," 180 were included. We summarized research progress organoids over past eight years by categorizing refining findings. Our analysis shows have achieved significant success simulating development vitro, leading to establishment refinement 3D organoid research. been widely applied explore disease-related mechanisms, yielding promising results opening avenues further on human brain. summarize three areas: culture methods, exploration.

Language: Английский

Citations

0