Crosstalk Between the Spleen and Other Organs/Systems: Downstream Signaling Events DOI Creative Commons
Giovanni Tarantino,

Vincenzo Citro

Immuno, Journal Year: 2024, Volume and Issue: 4(4), P. 479 - 501

Published: Nov. 8, 2024

The aim of this review was to gather pieces information from available critically evaluated published articles concerning any interplay in which the spleen could be involved. For many years, has been alleged as an unnecessary biological structure, even though splenomegaly is objective finding illnesses. Indeed, previous opinion completely changed. In fact, not a passive participant or simple bystander relationship that exists between immune system and other organs. Recently, it evidenced preclinical clinical studies there are close associations parts body, leading various spleen–organ axes. Among them, gut–spleen axis, liver–spleen gut–spleen–skin brain–spleen cardio-splenic axis most explored present medical literature. Such recent sources evidence have led revolutionary new ideas being developed about spleen. What more, these observations may enable identification novel therapeutic strategies targeted at current diseases. time come make clear superfluous body part, while health operators physicians should pay more attention organ. much work remains performed assess further roles structure play.

Language: Английский

Immune response to polystyrene microplastics: Regulation of inflammatory response via the ROS-driven NF-κB pathway in zebrafish (Danio rerio) DOI

Jincheng Pei,

Shannan Chen,

Q Ke

et al.

Aquatic Toxicology, Journal Year: 2025, Volume and Issue: 282, P. 107308 - 107308

Published: March 3, 2025

Language: Английский

Citations

2
Degradation of Polymer Materials in the Environment and Its Impact on the Health of Experimental Animals: A Review DOI Open Access
X. Zhang, Zhenxing Yin,

Songbai Xiang

et al.

Polymers, Journal Year: 2024, Volume and Issue: 16(19), P. 2807 - 2807

Published: Oct. 3, 2024

The extensive use of polymeric materials has resulted in significant environmental pollution, prompting the need for a deeper understanding their degradation processes and impacts. This review provides comprehensive analysis environment impact on health experimental animals. It identifies common polymers, delineates pathways, describes resulting products under different conditions. covers physical, chemical, biological mechanisms, highlighting complex interplay factors influencing these processes. Furthermore, it examines implications products, using animals as proxies assessing potential risks to human health. By synthesizing current research, focuses studies related small organisms (primarily rodents invertebrates, supplemented by fish mollusks) explore effects polymer living underscores urgency developing implementing effective waste management strategies. These strategies are crucial mitigating adverse impacts degradation, thus promoting more sustainable interaction between activities natural environment.

Language: Английский

Citations

12
Birds as Bioindicators: Revealing the Widespread Impact of Microplastics DOI Creative Commons
Lara Carrasco Pesquera,

Eva Jiménez-Mora,

Maria Jose Utrilla

et al.

Birds, Journal Year: 2025, Volume and Issue: 6(1), P. 10 - 10

Published: Feb. 11, 2025

The global crisis of plastic pollution, particularly involving microplastics (MPs) and nanoplastics (NPs), has profound ecological implications. Birds, serving as bioindicators, are especially susceptible to these pollutants. This systematic review synthesizes the current research on presence, distribution, impact MPs NPs avian species, alongside advancements in detection methodologies. have been identified over 200 bird species across 46 families, encompassing several ecosystems, from Antarctica Labrador, including Australia, China, South Europe. Seabirds such penguins, gulls, shearwaters exhibit a high burden tissues feces due fishing debris, while terrestrial face contamination urban agricultural sources. Depending their composition, can cause gastrointestinal damage, oxidative stress, bioaccumulation toxic chemicals, polyethylene polypropylene. However, challenges persist methodological inconsistencies, though advances spectroscopy flow cytometry offer improved accuracy. Addressing this pollution is vital for conservation ecosystem health, requiring international collaboration standardized protocols.

Language: Английский

Citations

1
Micro and nanoplastics pollution: A review on global concern and its impacts on ecosystems DOI
Sonkeshwar Sharma, Tanay Barman, Gaurav Mishra

et al.

Land Degradation and Development, Journal Year: 2024, Volume and Issue: 35(9), P. 2963 - 2981

Published: April 2, 2024

Abstract In recent decades, the ubiquity of micro and nanoplastics (MNPs) pollution has emerged as a global concern due to its potential risks both ecological human health. The detrimental effects MNPs have resulted in significant changes physicochemical biological properties terrestrial soil benthic sediment. These alterations led disrupted nutrient cycle, future climate hazards, further impacts on ecosystem services. This review aims discuss possible origins, composition, abundance, life transport processes aquatic ecosystems. It seeks understand health associated with explores their implications for biodiversity conservation Moreover, this highlights advanced analytical techniques used detect quantify MNPs. suggests policy frameworks combat natural environments. findings are intended assist environmentalists, microbiologists, hydrologists, policymakers identifying scientific gaps pragmatic solutions reduce pollution. Future research should investigate intake mechanism impact plants different ecosystems, well food chains will ensure that can be timely mitigated.

Language: Английский

Citations

5
Microplastics/nanoplastics contribute to aging and age-related diseases: mitochondrial dysfunction as a crucial role DOI
Liang Kong, Shuhao Li, Yu Fu

et al.

Food and Chemical Toxicology, Journal Year: 2025, Volume and Issue: 199, P. 115355 - 115355

Published: Feb. 26, 2025

Language: Английский

Citations

0
Toxicity enhancement of microplastics released from food containers through thermal aging: Absorbing more serum proteins thus activating the innate immune response via actin polymerization DOI Creative Commons
Fang Du, Ming Hou,

Song Lu

et al.

Environment International, Journal Year: 2025, Volume and Issue: 197, P. 109358 - 109358

Published: March 1, 2025

This study examined the effects of hot high-fat simulants on physicochemical properties microplastics (MPs) from polypropylene (PP)-, low-density polyethylene (LDPE)-, and polylactic acid (PLA)-based single-use food container (SUFC) leachates those aging their immunomodulatory effectors. Scenario studies have demonstrated that MPs were released these three types SUFCs. LDPE- PLA-based SUFCs also cellulose. Among SUFCs, only PP particles exhibited a new absorption peak at 1725 cm-1, which phenomenon may be attributed to presence unstable tertiary carbon atoms. Subsequently, we investigated removing additive both thermal-aged with polystyrene (PS) carboxyl-modified PS (PS-COOH) polymer backbones as reference materials. The findings indicated PS-COOH induced comparable innate immune responses, exhibiting similar size SUFC percolates. Consequently, selected original MPs, respectively, evaluate immunity. results revealed thata protein corona formed particle types, more adsorption observed particles. complex enhanced phagocytosis RAW264.7 macrophages increased expression pro-inflammatory genes NOS2 TNF-α through an actin polymerization cross-linking mechanism. In this study, how affect responses using model system, emphasizing importance comprehensive safety evaluations MPs.

Language: Английский

Citations

0
A critical review of the ecotoxic effects of microplastics on aquatic, soil and atmospheric ecosystems and current research challenges DOI
Haitao Yang, Shuyan Niu,

Menghao Guo

et al.

Environmental Research, Journal Year: 2025, Volume and Issue: 274, P. 121361 - 121361

Published: March 9, 2025

Language: Английский

Citations

0
Microplastic pollution: Critical analysis of global hotspots and their impact on health and ecosystems DOI
Veeramuthu Ashokkumar,

V.P. Chandramughi,

Kaustubha Mohanty

et al.

Journal of Environmental Management, Journal Year: 2025, Volume and Issue: 381, P. 124995 - 124995

Published: April 7, 2025

Language: Английский

Citations

0
Synergistic Effect of ROS and p38 MAPK in Apoptosis of TM4 Cells Induced by Titanium Dioxide Nanoparticles DOI
Pengfei Li, Xiaojia Meng, Tianjiao Lu

et al.

Journal of Applied Toxicology, Journal Year: 2025, Volume and Issue: unknown

Published: April 14, 2025

ABSTRACT The adverse effects of titanium dioxide nanoparticles (TiO 2 NPs) on the integrity blood–testis barrier (BTB) are widely recognized. However, underlying mechanisms remain incompletely understood. BTB is imperative for preservation male reproductive health. TM4 cells, which major component BTB, play a critical role in its integrity. apoptosis cells closely associated with disruption BTB. Therefore, we selected as experimental models to investigate induced by TiO NPs and mechanisms. Cell viability, excessive production reactive oxygen species (ROS), activation p38 mitogen‐activated protein kinase (MAPK) pathway, apoptosis‐related expression levels were determined under various concentrations (50, 100, 150, 200 μg/mL) exposure. results indicate that overproduction ROS activated MAPK signaling subsequently led apoptosis. scavenger N‐acetylcysteine (NAC) was able suppress pathway NPs, while inhibitor SB203580 mitigated NPs‐induced subsequent apoptosis, suggesting an interplay between activation. In summary, mitochondrial via ROS‐p38 axis. A positive feedback regulatory mechanism exists two processes, promoting through synergistic effect.

Language: Английский

Citations

0
Co-exposure to ozone and polystyrene nanoplastic exacerbates cognitive impairment and anxiety-like behavior by regulating neuronal pyroptosis in mice DOI Creative Commons

Anqi Dai,

Xudong Liu, Yinuo Chen

et al.

Environment International, Journal Year: 2025, Volume and Issue: 199, P. 109501 - 109501

Published: April 25, 2025

Ozone (O3) and nanoplastics (NPs) are pervasive environmental pollutants that frequently co-occur in our heavily industrialized era. While it has been documented exposure to O3 or NPs individually neurotoxic effects, studies investigating their combined impact the hazardous mechanisms resulting from co-exposure limited. In this study, we established a mouse model polystyrene nanoparticles (PS-NPs) O3, focusing on prefrontal cortex (PFC), brain region crucial for cognition emotion. We examined effects of PS-NPs behavioral changes related learning, memory, anxiety, employing transcriptome sequencing alongside molecular histopathological methods. Our findings indicate disrupts integrity blood-brain barrier, reducing Claudin 5 expression leading increased accumulation PFC. Transcriptome demonstrated involvement p38 mitogen-activated protein kinase (p38 MAPK) signaling pathway oxidative stress pathological observed Through immunohistochemical immunofluorescence analysis, enhanced microglial activation, which correlates with production inflammatory factors. Additionally, western blot co-labeling analyses revealed elevated levels GSDMD-N, caspase-1, IL-1β, IL-18 proteins, associated neuronal pyroptosis. Finally, confirmed activation MAPK neurons is involved co-exposure-induced Meanwhile, N-Acetylcysteine (NAC), common antioxidant, can alleviate neuroinflammation pyroptosis PFC, rescued cognitive deficits anxiety-like behaviors co-exposed mice. study illustrates aggravate damage barrier elevate thereby increasing occurrence may mediate through pathway, ultimately contributing neurobehavioral toxicity.

Language: Английский

Citations

0