Engineering exosomes to reshape the immune microenvironment in breast cancer: Molecular insights and therapeutic opportunities

Clinical and Translational Medicine, Journal Year: 2024, Volume and Issue: 14(4)

Published: April 1, 2024

Breast cancer remains a global health challenge, necessitating innovative therapeutic approaches. Immunomodulation and immunotherapy have emerged as promising strategies for breast treatment. Engineered exosomes are the sort of modified with surface decoration internal molecules. Through suitable modifications, engineered exhibit capability to overcome limitations associated traditional This ability opens up novel avenues development more effective, personalized, minimally invasive interventions.

Language: Английский

---

Zinc oxide nanoparticles promote migrasomes formation

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 490, P. 137792 - 137792

Published: Feb. 28, 2025

Language: Английский

---

Adverse Outcome Pathway-Based Strategies to Mitigate Ag₂Se Quantum Dot-Induced Neurotoxicity

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

Silver selenide quantum dots (Ag2Se QDs) show great advantages in tumor imaging due to their excellent optical performance and good biocompatibility. However, the ultrasmall particle size of Ag2Se QDs allows them cross blood-brain barrier, thus potentially affecting central nervous system. Therefore, risk assessment response strategies for are important. The adverse outcome pathway (AOP) framework makes it possible develop management based on toxicity mechanisms. In this study, using AOP framework, we constructed causal mechanism relationship diagrams at different biological levels QD neurotoxicity. excess mitochondrial reactive oxygen species (mtROS) triggered Nod-like receptor protein 3 (NLRP3) inflammasome activation microglia was molecular initiation event (MIE). Proinflammatory mediator secretion were key events (KEs) cellular level. Neuroinflammation neuronal damage KEs organ/tissue Altered hippocampal physiology (AO) individual Based established further studies confirmed that mtROS-activated nuclear-factor-E2-related factor 2 (Nrf2)/PTEN-induced kinase 1 (PINK1)- mitophagy contributed weaken MIE. Molecular docking-assisted biology experiments demonstrated quercetin (Qu) enhanced process. This article emphasizes importance nanomaterials. Furthermore, paper guides use natural small-molecule drugs as a strategy mitigate nanomaterial-induced

Language: Английский

---

Impact of polystyrene nanoplastics on apoptosis and inflammation in zebrafish larvae: Insights from reactive oxygen species perspective

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 948, P. 174737 - 174737

Published: July 14, 2024

Language: Английский

---

Navigating Neurotoxicity and Safety Assessment of Nanocarriers for Brain Delivery: Evaluation Models and Insights

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 189, P. 25 - 56

Published: Sept. 20, 2024

Language: Английский

---

Developing a feasible fast-track testing method for developmental neurotoxicity studies: alternative model for risk assessment of micro- and nanoplastics

Frontiers in Toxicology, Journal Year: 2025, Volume and Issue: 7

Published: April 15, 2025

Micro- and nanoplastics (MNPs) are widespread environmental pollutants that pose significant health risks. They originate from industrial processes, consumer products, degradation, inducing oxidative stress through cellular dysfunctions such as membrane interaction, internalization, mitochondrial damage, inflammation, metal ion leaching, impaired antioxidant defense. Despite increasing evidence of their toxicity—particularly developmental neurotoxicity (DNT) impairment—our understanding remains limited due to the high costs animal studies, which reduce overall size experimental data. This underscores urgent need for alternative test methods cost-effective, rapid, translational. review examines new approach methodologies (NAMs) DNT assessment, addressing ethical, financial, translational limitations models. NAMs integrate three complementary non-animal models enhance conventional testing. First, zebrafish provide organismal insights into behavioral neurodevelopmental outcomes at minimal cost. Second, neuronal organoids replicate human-specific processes in a 3D system, offering mechanistic insights. Lastly, human cell lines enable high-throughput screening, integrating findings organoid studies. Establishing paradigm testing is crucial faster more efficient toxicity risk assessments, ultimately protecting public health. Standardizing gaining regulatory acceptance will improve predictive accuracy broaden application toxicology. Advancing these essential risks MNP exposure while promoting ethical sustainable research practices.

Language: Английский

---

Attapulgite-Assisted In Situ Anchoring of Ultrasmall Ag Nanoparticles for Enhanced Eradication of Multidrug-Resistant Bacterial Biofilms and Accelerated Wound Healing

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: April 22, 2025

Silver nanoparticles (Ag NPs) have emerged as a promising solution to combat biofilm-related infections caused by multidrug-resistant bacteria. However, their practical application remains limited due tendency aggregate and exhibit high toxicity at elevated concentrations. Here, we developed Citrus limon peel water extract-mediated hydrothermal process facilitate the heterogeneous nucleation of Ag NPs on attapulgite (APT) nanorods prepared Ag/APT nanocomposites with ultrasmall (<2 nm) uniformly anchored APT nanorods. Ascorbic acid polyphenols in extract acted electron donors reduce Ag+ Ag0, while interfacial interaction induced confined growth nanocrystals, resulting NPs. As result, synergistic effect targeted biofilm-binding affinity siginificantly increased specific surface area conducive release ions, obtained exhibited enhanced eradication activities antimicrobial-resistant bacterial biofilms accelerated wound healing MRSA-infected models. Additionally, attributing low dosage Ag, exceptional biocompatibility both vitro vivo. This work provides simple green strategy for preparation highly active Ag-based antibacterial nanomaterials sheds new light development advanced antimicrobial agents healing.

Language: Английский

---

From bench to bedside: targeting ferroptosis and mitochondrial damage in the treatment of diabetic cardiomyopathy

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: April 25, 2025

Diabetic cardiomyopathy (DCM) is a common and fatal cardiac complication caused by diabetes, with its pathogenesis involving various forms of cell death mitochondrial dysfunction, particularly ferroptosis injury. Recent studies have indicated that damage play crucial roles in the onset progression DCM, though their precise regulatory mechanisms remain unclear. Of particular interest interaction between damage, as well synergistic effects, which are not fully understood. This review summarizes injury DCM explores molecular involved, an emphasis on interplay these two processes. Additionally, article offers overview targeted drugs shown to be effective cellular experiments, animal models, clinical trials, analyzing action potential side effects. The goal provide insights for future drug development applications. Moreover, challenges prospects multi-target combination therapies personalized medicine interventions practice offer strategic guidance comprehensive prevention management DCM.

Language: Английский

---

Mechanistic role of environmental toxicants in inducing cellular ferroptosis and its associated diseases

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 298, P. 118269 - 118269

Published: May 10, 2025

Language: Английский

---

Response mechanisms of microalgal-bacterial granular sludge to different loading strategies of copper oxide nanoparticles

Algal Research, Journal Year: 2025, Volume and Issue: 89, P. 104099 - 104099

Published: May 13, 2025

Language: Английский

---