Uncovering layer by layer the risk of nanoplastics to the environment and human health DOI
Joana Antunes, Paula Sobral, Vasco Branco

et al.

Journal of Toxicology and Environmental Health Part B, Journal Year: 2024, Volume and Issue: 28(2), P. 63 - 121

Published: Dec. 13, 2024

Nanoplastics (NPs), defined as plastic particles with dimensions less than 100 nm, have emerged a persistent environmental contaminant potential risk to both environment and human health. might translocate across biological barriers accumulate in vital organs, leading inflammatory responses, oxidative stress, genotoxicity, already reported several organisms. Disruptions cellular functions, hormonal balance, immune responses were also linked NPs exposure vitro assays. Further, been found adsorb other pollutants, such organic pollutants (POPs), leach additives potentially amplifying their advere impacts, increasing the threat organisms greater alone. However, toxic effects remain largely unexplored, requiring further research elucidate risks health, especially accumulation, degradation, migration, interactions systems long-term consequences of chronic these compounds. This review provides an overview current state-of-art regarding mechanisms toxicity within cells.

Language: Английский

Repeated measurements of urinary bisphenol A and its analogues in relation to sperm DNA damage DOI

Yang-Juan Li,

A-Xue Liu,

Jia-Yue Zeng

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 487, P. 137157 - 137157

Published: Jan. 8, 2025

Language: Английский

Citations

0
Enzymatic remediation of bisphenol A from wastewater in the presence of bio- and chemical-based additives: A machine learning study DOI
Ahmed Maged, Muntathir Alshabib, Salah Haridy

et al.

Journal of Molecular Liquids, Journal Year: 2025, Volume and Issue: unknown, P. 126881 - 126881

Published: Jan. 1, 2025

Language: Английский

Citations

0
Parental BPA Exposure Disrupts Offspring Transcriptomic Profiles and Impairs Embryonic Lineage Specification during Zygotic Genome Activation DOI Creative Commons
Yuequn Chen, Kusheng Wu, Wenlong Huang

et al.

Journal of Hazardous Materials Letters, Journal Year: 2025, Volume and Issue: unknown, P. 100146 - 100146

Published: Feb. 1, 2025

Language: Английский

Citations

0
Bisphenol analogues in soils and lettuce (Lactuca sativa L.) around typical factories in eastern China: Occurrence, contamination characteristics, and health risks DOI

Xindong Yang,

Chuanshun Dai,

Guoxia Zheng

et al.

Environmental Pollution, Journal Year: 2025, Volume and Issue: unknown, P. 126126 - 126126

Published: March 1, 2025

Language: Английский

Citations

0
Impact of BPA and its analogs on sperm hyperactivity, acrosome reaction, epigenetic profiles and in vitro embryo development. DOI Creative Commons

Ola S. Davis,

Olivia L M Scandlan,

Erica A Potestio

et al.

Molecular and Cellular Endocrinology, Journal Year: 2025, Volume and Issue: unknown, P. 112555 - 112555

Published: April 1, 2025

Language: Английский

Citations

0
Effects of salinity on behavior and reproductive toxicity of BPA in adult marine medaka DOI
Zuchun Chen, Xueyou Li,

Jiahao Gao

et al.

Chemosphere, Journal Year: 2024, Volume and Issue: 357, P. 142103 - 142103

Published: April 21, 2024

Language: Английский

Citations

3
Parabens, bisphenols, and triclosan in coral polyps, algae, and sediments from Sanya, China: Occurrence, profiles, and environmental implications DOI
Yiming Ge,

Han Zhang,

Jinfeng Fu

et al.

Environmental Pollution, Journal Year: 2024, Volume and Issue: 361, P. 124839 - 124839

Published: Aug. 28, 2024

Language: Английский

Citations

1
Environmentally-relevant doses of bisphenol A and S exposure in utero disrupt germ cell programming across generations resolved by single nucleus multi-omics DOI Creative Commons
Liang Zhao, Mingxin Shi, Sarayut Winuthayanon

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 10, 2024

Abstract Background Exposure to endocrine-disrupting chemicals (EDCs), such as bisphenol A (BPA), disrupts reproduction across generations. Germ cell epigenetic alterations are proposed bridge transgenerational reproductive defects resulting from EDCs. Previously, we have shown that prenatal exposure environmentally relevant doses of BPA or its substitute, BPS, caused transgenerationally maintained impairments associated with neonatal spermatogonial changes in male mice. While germ cells can lead phenotypic variations, the mechanisms sustaining these generations remain unclear. Objectives This study aimed systematically elucidate mechanism inherence by and BPS murine germline F1 F3 at both transcriptomic levels. Methods 0 (vehicle control), 0.5, 50, 1000 µg/kg/b.w./day was orally administered pregnant CD-1 females (F0) gestational day 7 birth. Sperm counts motility were examined F1, F2, adult males. THY1 + on postnatal 6 males a dose 50 used for analysis single-nucleus (sn) multi-omics (paired snRNA-seq snATAC-seq same nucleus). Results Prenatal reduced sperm mice In cells, ancestral resulted increased differentially expressed genes (DEGs) differentiation. It also disrupted balance between maintaining undifferentiated differentiating populations. Differentially accessible peaks (DAPs) primarily located promoter regions, elevated activity key transcription factors, including SP1, SP4, DMRT1. Throughout F1-F3 generations, biological processes related mitosis/meiosis metabolic pathways substantially up-regulated BPA-or BPS-exposed groups. quantities DEGs DAPs similar F2 spermatogonia, showing significant reduction F3. Notably, approximately 80% spermatogonia overlapped histone post-translational modifications linked activation, H3K4me1/2/3 H3K27ac. Although exerted more potent effects gene expression induced longer-lasting differentiation Interestingly, DMRT1 motif persistently all three following exposure. Discussion Our work provides first systematic analyses understanding dynamics chromatin landscape spermatogonia. These results suggest alters accessibility factor activities, consequently contributing transcriptional levels some sustained ultimately leading adults.

Language: Английский

Citations

0
Reproductive toxicity of bisphenol A and nitro-bisphenol A in male zebrafish at environmentally relevant concentrations DOI
Chao Wang, Shuyi Zhang,

Zijin Shao

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 958, P. 177905 - 177905

Published: Dec. 13, 2024

Language: Английский

Citations

0
Uncovering layer by layer the risk of nanoplastics to the environment and human health DOI
Joana Antunes, Paula Sobral, Vasco Branco

et al.

Journal of Toxicology and Environmental Health Part B, Journal Year: 2024, Volume and Issue: 28(2), P. 63 - 121

Published: Dec. 13, 2024

Nanoplastics (NPs), defined as plastic particles with dimensions less than 100 nm, have emerged a persistent environmental contaminant potential risk to both environment and human health. might translocate across biological barriers accumulate in vital organs, leading inflammatory responses, oxidative stress, genotoxicity, already reported several organisms. Disruptions cellular functions, hormonal balance, immune responses were also linked NPs exposure vitro assays. Further, been found adsorb other pollutants, such organic pollutants (POPs), leach additives potentially amplifying their advere impacts, increasing the threat organisms greater alone. However, toxic effects remain largely unexplored, requiring further research elucidate risks health, especially accumulation, degradation, migration, interactions systems long-term consequences of chronic these compounds. This review provides an overview current state-of-art regarding mechanisms toxicity within cells.

Language: Английский

Citations

0