IOP Conference Series Earth and Environmental Science,
Journal Year:
2024,
Volume and Issue:
1414(1), P. 012034 - 012034
Published: Dec. 1, 2024
Abstract
Amoxicillin
can
have
adverse
effects
on
non-target
bacteria
in
aquatic
environments,
causing
disruption
to
the
balance
of
ecosystems
and
promoting
emergence
antibiotic
resistance.
The
Advanced
Oxidation
Process,
namely
UV/H
2
O
,
is
a
promising
method
for
degradation
antibiotics
such
as
amoxicillin
due
its
effectiveness.
However,
products
might
ecotoxic
potential
not
been
studied;
therefore,
this
study
aims
evaluate
ecotoxicity
using
.
silico
was
conducted
ECOSAR
theoretically
assess
ensuing
transformation
organisms.
calculations
offer
an
early
assessment
possible
hazard
environment.
research
result
shows
that
overall
from
approach
are
harmful
ecotoxicity,
although
some
by-products
still
possess
potential.
Moreover,
findings
suggest
mineralization
level
relatively
low
production
hazardous
compounds
resistant
hydroxyl
radical
attack.
This
highlights
necessity
more
comprehensive
understanding
produced
by
process
their
influence
ecosystems.
Infection and Drug Resistance,
Journal Year:
2025,
Volume and Issue:
Volume 18, P. 61 - 76
Published: Jan. 1, 2025
To
evaluate
the
long-term
impacts
of
feedback
intervention
on
controlling
inappropriate
use
antimicrobial
prescriptions
in
primary
care
institutions
China,
as
a
continuation
previous
trial.
After
ended,
we
conducted
12-month
follow-up
study.
The
prescription
data
were
collected
from
baseline
until
end
period.
generalized
estimation
equation
was
employed
to
analyze
differences
among
four
representative
time
points:
at
point,
3
months,
6
and
18
months.
time-intervention
interaction
utilized
changing
trends
group
A
B.
Our
outcome
variable
is
monthly
rate
(IAPR).
adjusting
for
covariates,
IAPRs
decreased
by
1.00%
average
point
5.00%
months
-0.92%
0.39%
During
corresponding
periods
B,
decline
2.33%,
3.67%,
-0.42%,
0.72%,
respectively.
As
rates
(APRs),
1.33%,
0.17%
during
three
periods:
Accordingly
1.00%,
0.08%,
generated
limited
impacts.
Although
APRs
consistently
remained
below
both
experienced
rebound
within
certain
range
following
stop
two
groups.
It
reasonable
think
that
desired
effects
will
be
difficult
maintain
without
sustained
implementation
intervention.
Advances in Oceanography and Limnology,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: Jan. 16, 2025
In
2015,
the
World
Health
Organization
(WHO)
declared
Antimicrobial
Resistance
(AMR)
as
one
of
most
critical
health
issues.
It
proposed,
with
Food
and
Agriculture
(FAO)
OIE
(World
for
Animal
Health),
to
address
this
by
a
One
approach,
recognizing
connection
between
humans,
animals,
environmental
health.
Currently,
hypothesis
is
developing
that
cyanobacteria
cyanotoxins
may
contribute
AMR
in
water.
Recent
research
appears
suggest:
i)
an
impact
on
antibiotic-resistance
gene
transfer
bacteria;
ii)
role
reservoir
AMR.
Finally,
cyanotoxin
production
be
stimulated
exposure
antibiotics.
These
findings
strengthen
importance
considering
environment
its
complexity.
BioEssays,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 27, 2025
The
public
health
issue
of
bacterial
multi-resistance
to
antibiotics
has
gained
awareness
among
the
public,
researchers,
and
pharmaceutical
sector.
Nevertheless,
spread
antimicrobial
resistance
been
considerably
aggravated
by
human
activities,
climate
change,
subsequent
increased
release
antibiotics,
drug-resistant
bacteria,
antibiotic
genes
in
environment.
extensive
use
for
medical
veterinary
purposes
not
only
induced
increasing
but
also
other
problems,
including
negative
effects
on
patient's
microbiome.
Preventive
strategies,
new
treatment
modalities,
surveillance
are
progressively
set
up.
A
comprehensive
approach
is,
however,
lacking
urgently
tackling
this
adverse
situation.
To
address
challenge,
we
discussed
here
main
causes
driving
pollution
environment
factors
favorable
emergence
drug
resistance.
We
next
propose
some
key
priorities
research,
prevention,
surveillance,
education
supervise
an
effective
clinical
sustainable
response.
Pharmaceuticals,
Journal Year:
2024,
Volume and Issue:
17(4), P. 537 - 537
Published: April 22, 2024
The
United
Nations
World
Drug
Report
published
in
2022
alarmed
that
the
global
market
of
illicit
drugs
is
steadily
expanding
space
and
scale.
Substances
abuse
are
usually
perceived
light
threats
to
human
health
public
security,
while
environmental
aspects
their
use
subsequent
emissions
remain
less
explored.
However,
as
with
other
activities,
drug
production,
trade,
consumption
may
leave
mark.
Therefore,
this
paper
aims
review
occurrence
surface
waters
bioaccumulation
toxicity
fish.
Illicit
different
groups,
i.e.,
psychostimulants
(methamphetamines/amphetamines,
cocaine,
its
metabolite
benzoylecgonine)
depressants
(opioids:
morphine,
heroin,
methadone,
fentanyl),
can
reach
aquatic
environment
through
wastewater
discharge
they
often
not
entirely
removed
during
treatment
processes,
resulting
circulation
nanomolar
concentrations,
potentially
affecting
biota,
including
Exposure
such
xenobiotics
induce
oxidative
stress
dysfunction
mitochondrial
lysosomal
function,
distort
locomotion
activity
by
regulating
dopaminergic
glutamatergic
systems,
increase
predation
risk,
instigate
neurological
disorders,
disbalance
neurotransmission,
produce
histopathological
alterations
brain
liver
tissues,
similar
those
described
mammals.
Hence,
drugs-related
multidimensional
harm
fish
should
be
thoroughly
investigated
line
protection
policies
before
it
too
late.
At
same
time,
selected
species
(e.g.,
Danio
rerio,
zebrafish)
employed
models
study
toxic
binge-like
effects
psychoactive,
compounds.
