Microbial diversity and fitness in the gut–brain axis: influences on developmental risk for Alzheimer’s disease

Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)

Published: April 10, 2025

The gut-brain axis (GBA) denotes the dynamic and bidirectional communication system that connects gastrointestinal tract central nervous (CNS). This review explored this axis, focusing on role of microbial diversity fitness in maintaining health preventing neurodegeneration, particularly Alzheimer's disease (AD). Gut dysbiosis, characterized by imbalance populations beneficial harmful bacteria, has been associated with increased systemic inflammation, neuroinflammation, progression AD through pathogenic mechanisms involving amyloid deposition, tauopathy, blood-brain barrier (BBB) permeability. Emerging evidence highlighted therapeutic potential probiotics, dietary interventions, intermittent fasting restoring balance, reducing minimizing neurodegenerative risks. Probiotics synbiotics are promising helping improve cognitive function metabolic health, while patterns like Mediterranean diet were linked to decreased neuroinflammation enhanced communication. Despite significant advancement, further research is needed elucidate specific strains, metabolites, influencing brain health. Future studies employing longitudinal designs advanced omics technologies essential developing targeted microbiome-based therapies for managing AD-related disorders.

Language: Английский

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Emerging Roles of Histone modifications in Environmental Toxicants-Induced Neurotoxicity

Toxicology, Journal Year: 2025, Volume and Issue: 515, P. 154164 - 154164

Published: April 24, 2025

Language: Английский

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Refining the relationship between gut microbiota and common hematologic malignancies: insights from a bidirectional Mendelian randomization study

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: June 14, 2024

Background The relationship between gut microbiota and hematologic malignancies has attracted considerable attention. As research progresses, it become increasingly clear that the composition of may influence onset progression malignancies. However, our understanding this association remains limited. Methods In study, we classified into five groups based on information at phylum, class, order, family, genus levels. Subsequently, obtained data related to common from IEU Open GWAS project. We then employed a bidirectional Mendelian Randomization (MR) approach determine whether there is causal Additionally, conducted MR analyses ascertain directionality relationship. Results Through forward reverse analyses, found risk lymphoid leukemia was significantly associated with abundance phylum Cyanobacteria, order Methanobacteriales, class Methanobacteria, family Peptococcaceae, Methanobacteriaceae, genera Lachnospiraceae UCG010, Methanobrevibacter, Eubacterium brachy group, Butyrivibrio. myeloid Actinobacteria, Firmicutes, Bifidobacteriales, Clostridiales, Gammaproteobacteria, Clostridia, Bifidobacteriaceae, Fusicatenibacter, hallii Blautia, Collinsella, Ruminococcus gauvreauii Bifidobacterium. Hodgkin lymphoma Clostridiales vadinBB60 Peptococcus, Ruminococcaceae UCG010. malignant plasma cell tumor Romboutsia rectale group. diffuse large B-cell Erysipelatoclostridium coprostanoligenes mature T/NK lymphomas Verrucomicrobia, UCG013, Lachnoclostridium, Lastly, myeloproliferative neoplasms Coprococcus 3 Conclusion Our study provided new evidence for malignancies, offering novel insights approaches prevention treatment these tumors.

Language: Английский

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Evaluating heavy metals-related risk in staple crops and making financing strategy for corresponding soil remediation across China

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 480, P. 136135 - 136135

Published: Oct. 10, 2024

Language: Английский

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The Effects of Seleno-Methionine in Cadmium-Challenged Human Primary Chondrocytes

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(7), P. 936 - 936

Published: July 12, 2024

Cadmium (Cd) is a potentially toxic element able to interfere with cellular functions and lead disease or even death. Cd accumulation has been demonstrated in cartilage, where it can induce damage joints. The aim of this study was evaluate the effect CdCl2 on primary cultures human chondrocytes possible protective seleno-methionine (Se-Met). Human articular were cultured treated as follows: control groups, cells challenged 7.5 μM 10 alone, pretreated 20 Se-Met then CdCl2. Twenty-four hours after incubation, cell viability, histological evaluation hematoxylin–eosin stain, terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay performed. Furthermore, reverse transcription-PCR carried out mRNA levels BAX, BAK1, CASP-3, CASP-9. After challenge at both doses, reduced viability an overexpression CASP-9 genes, well high number TUNEL-positive cells, demonstrated, all parameters becoming higher dose increased. pretreatment lowered expression considered improved morphological changes, cells. It concluded that plays role against CdCl2-induced structural functional changes vitro, showed positive context apoptotic pathways. therefore suggested translational, multifaceted approach, plant-based diets, bioactive foods, nutraceuticals, micronutrients, drugs, possibly advisable situations environmental pollution caused by elements.

Language: Английский

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Ecological characteristics of tall fescue and spatially organized communities: their contribution to mitigating cadmium damage

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 480, P. 135953 - 135953

Published: Sept. 24, 2024

Language: Английский

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