STEAP3-SLC39A8-mediated microglia ferroptosis involved in neurotoxicity in rats after exposure to lead and cadmium combined DOI Creative Commons

Yuxin Sun,

Jian‐Wei Liu, Kang Xiao

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 146, P. 113854 - 113854

Published: Dec. 20, 2024

Language: Английский

Nuclear receptor coactive 4-mediated ferritinophagy: a key role of heavy metals toxicity DOI

Wan-Xue Xu,

Wen Xue, Yupeng Fu

et al.

Archives of Toxicology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 10, 2025

Language: Английский

Citations

0
Effect of Interaction of ATG7 and Plasma Metal Concentrations on Cognitive Impairment in Rural China DOI
Xu Tang,

Jiejing Cao,

Jiansheng Cai

et al.

Journal of Molecular Neuroscience, Journal Year: 2025, Volume and Issue: 75(1)

Published: Feb. 24, 2025

Language: Английский

Citations

0
Hexavalent chromium induces ferroptosis in small intestinal tissue of broilers through GPX4/HMGB1/p38-MAPK pathway DOI Creative Commons

Juezhang Wang,

Bo Fan, Weina Liu

et al.

Poultry Science, Journal Year: 2025, Volume and Issue: 104(4), P. 104978 - 104978

Published: March 3, 2025

As a major environmental heavy metal pollutant, hexavalent chromium (Cr(VI)) causes irreversible damage to animals and humans. Nevertheless, how Cr(VI) exposure intestinal in broilers remains inadequately explored. This study explores Cr(VI)-induced poisoning using potassium dichromate build model. The results indicate that evidently reduced the body weight functions of liver kidney broilers. Histopathological analysis revealed different degrees structural all three segments small intestines by exposure. Moreover, downregulated ZO-1, Occludin, Claudin-1, while altering diversity cecal microbiota impair barrier function. Additionally, with increasing concentration, contents Fe2+, ROS, LPO showed dose-dependent increase. levels GPX4, SLC7A11, FTL, FTH1 were Cr(VI), p38-MAPK, phosphorylated p38, TFR1, HMGB1 upregulated. suggests ROS can trigger ferroptosis through GPX4/HMGB1/p38-MAPK pathway, leading dysfunction ultimately reducing production performance provides foundation theory for understanding effects on intestine.

Language: Английский

Citations

0
Gestational and lactational exposure to DEHP triggers ACSL4/TFR-mediated hippocampal neuronal ferroptosis via YAP activation: implication for the neurocognitive disorders in male offspring DOI

Pu Zhao,

Yang Zhao,

Yilu Ma

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: unknown, P. 138081 - 138081

Published: March 1, 2025

Language: Английский

Citations

0
Cadmium treatment induces oxidative damage and apoptosis in vitro skeletal muscle cells DOI
Wenhong Luo, Jie Yang, Yuan Zhao

et al.

Toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 154139 - 154139

Published: April 1, 2025

Language: Английский

Citations

0
Short-term respiratory cadmium exposure partially activates pulmonary NLRP3 inflammasome by inducing ferroptosis in mice DOI Creative Commons
Li Zhao,

Yaxin Yao,

Xue Lu

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 285, P. 117106 - 117106

Published: Sept. 25, 2024

Language: Английский

Citations

3
Acute waterborne cadmium exposure induces liver ferroptosis in Channa argus DOI Creative Commons
Xingyu Chen, Wenqian Sun,

Yanting Song

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 283, P. 116947 - 116947

Published: Aug. 29, 2024

The impact of cadmium (Cd) toxicity on fish liver injury has received much attention in recent years. Currently, autophagy, apoptosis and endoplasmic reticulum stress were reported Cd exposed liver, if there are other mechanisms (such as ferroptosis) relevant signaling pathways involved remains unknown. An experiment was conducted to investigate Channa argus (Cantor, 1842) 0, 1.0, 2.0 mg Cd/L water for 96 h. disrupted the structure mitochondria liver. Besides, induced ferroptosis by significantly increasing level Fe

Language: Английский

Citations

1
Ellagic Acid Reduces Cadmium Exposure-Induced Apoptosis in HT22 Cells via Inhibiting Oxidative Stress and Mitochondrial Dysfunction and Activating Nrf2/HO-1 Pathway DOI Creative Commons
Yue Liu, Chun‐Hong Chen, Zhihui Hao

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(11), P. 1296 - 1296

Published: Oct. 25, 2024

Exposure to cadmium sulfate (CdSO

Citations

1
Dietary interventions in mitigating the impact of environmental pollutants on Alzheimer’s disease – A review DOI
Pratima Khandayataray, Meesala Krishna Murthy

Neuroscience, Journal Year: 2024, Volume and Issue: 563, P. 148 - 166

Published: Nov. 13, 2024

Language: Английский

Citations

0
The ameliorative effects of melatonin against BDE-47-induced hippocampal neuronal ferroptosis and cognitive dysfunction through Nrf2-Chaperone-mediated autophagy of ACSL4 degradation DOI Creative Commons
Quan Yuan,

Mingwei Wang,

Zhaoxiang Zhang

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 290, P. 117542 - 117542

Published: Dec. 18, 2024

Language: Английский

Citations

0