Rice Straw-Derived Biochar Mitigates Microcystin-LR-Induced Hepatic Histopathological Injury and Oxidative Damage in Male Zebrafish via the Nrf2 Signaling Pathway DOI Creative Commons
Wang Lin, Fen Hu,

Wansheng Zou

et al.

Toxins, Journal Year: 2024, Volume and Issue: 16(12), P. 549 - 549

Published: Dec. 18, 2024

Microcystin-leucine arginine (MC-LR) poses a serious threat to aquatic animals during cyanobacterial blooms. Recently, biochar (BC), derived from rice straw, has emerged as potent adsorbent for eliminating hazardous contaminants water. To assess the joint hepatotoxic effects of environmentally relevant concentrations MC-LR and BC on fish, male adult zebrafish (Danio rerio) were sub-chronically co-exposed varying (0, 1, 5, 25 μg/L) (0 100 in fully factorial experiment. After 30 days exposure, our findings suggested that existence significantly decreased bioavailability liver. Furthermore, histopathological analysis revealed mitigated MC-LR-induced hepatic lesions, which characterized by mild damage, such vacuolization, pyknotic nuclei, swollen mitochondria. Compared groups exposed solely MC-LR, malondialdehyde (MDA) increased catalase (CAT) superoxide dismutase (SOD) noticed mixture groups. Concurrently, significant changes mRNA expression levels Nrf2 pathway genes (cat, sod1, gstr, keap1a, nrf2a, gclc) further proved reduces oxidative damage induced MC-LR. These demonstrate decreases liver, thereby alleviating hepatotoxicity through signaling zebrafish. Our results also imply could serve potentially friendly material mitigating detrimental fish.

Language: Английский

The histopathological and functional consequences of microplastic exposure DOI Creative Commons

Yujeong Lee,

Min Kyung Sung, Soo‐Eun Sung

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: 7(1)

Published: Jan. 11, 2025

As the production, usage, and disposal of plastics increase, microplastics generated—plastic particles smaller than 5 mm—increases, exacerbating environmental pollution. In turn, various organisms become increasingly exposed to contaminated environments, potentially affecting humans through food chain. Crucial findings from in vivo experiments indicate histopathological changes caused by impact morphology physiological function organisms. This study describes induced across circulatory, nervous, digestive, respiratory, reproductive systems explains associated functional alterations. Except nervous system, main morphological involve degenerative throughout body, such as apoptosis, inflammation, fibrosis. Most were inflammatory responses microplastics, leading fibrosis subsequent impairments. Various studies confirm that stimulate cells, increased reactive oxygen species cell death. Consequently, these impair related systemic functions. review highlights fundamental organs cells due discusses limitations involving showing no changes.

Language: Английский

Citations

2

Mitigating Dietary Microplastic Accumulation and Oxidative Stress Response in European Seabass (Dicentrarchus labrax) Juveniles Using a Natural Microencapsulated Antioxidant DOI Creative Commons
Matteo Zarantoniello, Nico Cattaneo, Federico Conti

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(7), P. 812 - 812

Published: July 5, 2024

Aquafeed's contamination by microplastics can pose a risk to fish health and quality since they be absorbed the gastrointestinal tract translocate different tissues. The liver acts as retaining organ with consequent triggering of oxidative stress response. present study aimed combine use natural astaxanthin natural-based microcapsules counteract these negative side effects. European seabass juveniles were fed diets containing commercially available fluorescent microplastic microbeads (1-5 μm; 50 mg/kg feed) alone or combined microencapsulated (AX) (7 g/kg feed; tested for half whole feeding trial-30 60 days, respectively). Fish from dietary treatments did not evidence variations in survival growth performance show pathological alterations at intestinal level. However, level translocation liver, leading, when provided solely,

Language: Английский

Citations

5

Are (bio)electrochemical techniques sustainable solutions to combat micro- and nano-plastic pollution? DOI
Almeenu Rasheed, Yasser Bashir, Sovik Das

et al.

Current Opinion in Chemical Engineering, Journal Year: 2025, Volume and Issue: 47, P. 101091 - 101091

Published: Jan. 20, 2025

Language: Английский

Citations

0

The influence of microplastics on hypertension-associated cardiovascular injury via the modulation of gut microbiota DOI
Siyuan Wang,

Keying Yan,

Ying Dong

et al.

Environmental Pollution, Journal Year: 2025, Volume and Issue: unknown, P. 125760 - 125760

Published: Jan. 1, 2025

Language: Английский

Citations

0

Effects of tefluthrin exposure on early life stages in zebrafish: Insights into cardiac and skeletal development, oxidative stress and apoptosis DOI Creative Commons

Yuanzhao Wu,

Ying Zhu,

An Cheng

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 292, P. 117931 - 117931

Published: Feb. 19, 2025

Language: Английский

Citations

0

Understanding the Mechanism of Cardiotoxicity Induced by Nanomaterials: A Comprehensive Review DOI Creative Commons
Zaiyong Zheng, Shuang Zhu, Xiaobo Wang

et al.

Small Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 20, 2025

Nanomaterials have been vastly used in daily life. However, owing to their unique properties, nanomaterials also show potential side effects. Among the various organs affected by nanomaterials, circulatory system stands out as particularly vulnerable, drawing additional attention its cardiac toxicity. To address cardiovascular nanotoxicity and further promote safe use of nanotechnology, a comprehensive review cardiotoxicity induced is provided. The begins identifying current research trends hotspots this field via bibliometric analysis. Subsequently, based on objectively obtained hotspots, mechanism nanotoxicity, including exposure route, membrane injury, ion disturbance, oxidative stress, inflammation, cell death, reviewed discussed. Finally, strategies for mitigation are proposed. objective assist readers understanding facilitate application human health.

Language: Английский

Citations

0

A comprehensive review of the calcium dynamics of environmental pollutants in human health: insights from zebrafish models DOI
Hahyun Park

Molecular & Cellular Toxicology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

Language: Английский

Citations

0

Assessing toxicological risk of nanoplastics contaminants in food and feed from ingestion pathway to human diseases DOI Creative Commons
Pipin Agnesia,

Yan Erisma Gangga,

Renata Adaranyssa Egistha Putri

et al.

F1000Research, Journal Year: 2025, Volume and Issue: 14, P. 284 - 284

Published: March 12, 2025

The extensive use of plastic without an effective management system is linked to significant environmental pollution issues. The fragmentation various types waste leads the formation microplastics (MPs) and nanoplastics (NPs). NPs, measuring less than 0.1 μm pose a latent danger human food chain caused by ability traverse biological membranes MPs, potentially leading chronic diseases. widespread distribution NPs across diverse matrices their subsequent infiltration into feed chains precipitates emerging health concerns. contaminate production systems leach from packaging, infiltrating organisms at trophic levels. Seafood, processed foods, drinking water serve as vectors for absorption accumulation in tissues. pervasive contamination pathway poses substantial risks through multiple exposure routes, primarily ingestion. It can lead cytotoxicity, inflammation, genotoxicity, apoptosis. This review summarizes implications that triggers diseases such inflammatory bowel disease (IBD), kidney dysfunction, liver disease, heart problems, brain disorders, reproductive issues, cancer. Currently, no established method exists treat humans may have already ingested. Hence, it urgent mitigate harmful effects development implementation innovative, efficient, sustainable decontamination strategies. discussion highlights several advanced remediation techniques effectively reduce toxicity systems, thus mitigating associated risks.

Language: Английский

Citations

0

Polyethylene microplastics perforate the chorion defense, triggering developmental cardiotoxicity at zebrafish DOI
Yejin Kim,

Hyerin Lee,

Yun Hak Kim

et al.

Aquatic Toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 107331 - 107331

Published: March 1, 2025

Language: Английский

Citations

0

Aged microplastics-induced growth inhibition via DNA damage, GH/IGF-1 and HPT axes disruption in zebrafish larvae DOI
Qing Ge,

Tong Zheng,

Ping Ding

et al.

The Science of The Total Environment, Journal Year: 2025, Volume and Issue: 975, P. 179215 - 179215

Published: April 7, 2025

Language: Английский

Citations

0