Rice Straw-Derived Biochar Mitigates Microcystin-LR-Induced Hepatic Histopathological Injury and Oxidative Damage in Male Zebrafish via the Nrf2 Signaling Pathway DOI Creative Commons
Wang Lin, Fen Hu,

Wansheng Zou

et al.

Toxins, Journal Year: 2024, Volume and Issue: 16(12), P. 549 - 549

Published: Dec. 18, 2024

Microcystin-leucine arginine (MC-LR) poses a serious threat to aquatic animals during cyanobacterial blooms. Recently, biochar (BC), derived from rice straw, has emerged as potent adsorbent for eliminating hazardous contaminants water. To assess the joint hepatotoxic effects of environmentally relevant concentrations MC-LR and BC on fish, male adult zebrafish (Danio rerio) were sub-chronically co-exposed varying (0, 1, 5, 25 μg/L) (0 100 in fully factorial experiment. After 30 days exposure, our findings suggested that existence significantly decreased bioavailability liver. Furthermore, histopathological analysis revealed mitigated MC-LR-induced hepatic lesions, which characterized by mild damage, such vacuolization, pyknotic nuclei, swollen mitochondria. Compared groups exposed solely MC-LR, malondialdehyde (MDA) increased catalase (CAT) superoxide dismutase (SOD) noticed mixture groups. Concurrently, significant changes mRNA expression levels Nrf2 pathway genes (cat, sod1, gstr, keap1a, nrf2a, gclc) further proved reduces oxidative damage induced MC-LR. These demonstrate decreases liver, thereby alleviating hepatotoxicity through signaling zebrafish. Our results also imply could serve potentially friendly material mitigating detrimental fish.

Language: Английский

Protective Effect of Artemisinin Against Luperox Induced Oxidative Stress and Insulin Resistance via Pi3k/Akt Pathway in Zebrafish Larvae DOI
Kadhirmathiyan Velumani, Priyanka Rajan, Mohammed Rafi Shaik

et al.

Cell Biochemistry and Biophysics, Journal Year: 2025, Volume and Issue: unknown

Published: April 12, 2025

Language: Английский

Citations

0

PVC Nanoplastics Impair Cardiac Function via Lysosomal and Mitochondrial Dysfunction DOI
Guoxia Liu,

Qimei Bao,

Chunkai Zhang

et al.

Biochemical and Biophysical Research Communications, Journal Year: 2025, Volume and Issue: unknown, P. 151736 - 151736

Published: April 1, 2025

Language: Английский

Citations

0

Are microplastics a new cardiac threat? A pilot study with wild fish from the North East Atlantic Ocean DOI Creative Commons
Luís Gabriel A. Barboza, Sara Couto Lourenço, Alexandre Aleluia

et al.

Environmental Research, Journal Year: 2024, Volume and Issue: 261, P. 119694 - 119694

Published: July 27, 2024

Global environmental contamination by microplastics (MPs) is a growing problem with potential One Health impacts. The presence of MPs in vital organs, such as the heart, particular concern, but knowledge still limited. goal present pilot study was to investigate heart wild specimens three commercial fish species (Merluccius merluccius, Sardina pilchardus, and Trisopterus luscus) from North East Atlantic Ocean. Heart samples 154 were analysed for MP content (one sample per fish). A total 44 recovered species. had varied chemical composition (5 polymers), shapes (4) colours (5). Differences profile among observed (p ≤ 0.05). Thirty (19%) their hearts, mean (±SD) concentration 0.286 ± 0.644 MPs/fish. S. pilchardus highest There no significant > 0.05) differences between M. merluccius T. luscus. These findings different biological ecological traits together literature data suggest that likely disseminated phenomenon. Therefore, further research on cardiovascular system its health effects very much needed.

Language: Английский

Citations

2

Mitigation PFHxA-induced neurotoxicity in Carassius auratus brain cells by selenium-enriched Bacillus subtilis via the BDNF/PI3K/AKT/GSK-3β pathway DOI Creative Commons
Yuting Lu,

Zheng-yao Guo,

Lei Guo

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 290, P. 117567 - 117567

Published: Dec. 18, 2024

Language: Английский

Citations

1

Rice Straw-Derived Biochar Mitigates Microcystin-LR-Induced Hepatic Histopathological Injury and Oxidative Damage in Male Zebrafish via the Nrf2 Signaling Pathway DOI Creative Commons
Wang Lin, Fen Hu,

Wansheng Zou

et al.

Toxins, Journal Year: 2024, Volume and Issue: 16(12), P. 549 - 549

Published: Dec. 18, 2024

Microcystin-leucine arginine (MC-LR) poses a serious threat to aquatic animals during cyanobacterial blooms. Recently, biochar (BC), derived from rice straw, has emerged as potent adsorbent for eliminating hazardous contaminants water. To assess the joint hepatotoxic effects of environmentally relevant concentrations MC-LR and BC on fish, male adult zebrafish (Danio rerio) were sub-chronically co-exposed varying (0, 1, 5, 25 μg/L) (0 100 in fully factorial experiment. After 30 days exposure, our findings suggested that existence significantly decreased bioavailability liver. Furthermore, histopathological analysis revealed mitigated MC-LR-induced hepatic lesions, which characterized by mild damage, such vacuolization, pyknotic nuclei, swollen mitochondria. Compared groups exposed solely MC-LR, malondialdehyde (MDA) increased catalase (CAT) superoxide dismutase (SOD) noticed mixture groups. Concurrently, significant changes mRNA expression levels Nrf2 pathway genes (cat, sod1, gstr, keap1a, nrf2a, gclc) further proved reduces oxidative damage induced MC-LR. These demonstrate decreases liver, thereby alleviating hepatotoxicity through signaling zebrafish. Our results also imply could serve potentially friendly material mitigating detrimental fish.

Language: Английский

Citations

0