Health effects of synthetic additives and the substitution potential of plant-based additives DOI
Jiaqi Chen, Pengguo Xia

Food Research International, Journal Year: 2024, Volume and Issue: 197, P. 115177 - 115177

Published: Oct. 5, 2024

Language: Английский

Sinensetin attenuates hepatic ischemia-reperfusion injury through suppressing GRP78/CHOP-mediated endoplasmic reticulum (ER) stress in mice DOI Creative Commons
Yihong Yang, Guanghua Xiong,

Huangqi Shi

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 12, 2025

Objective Hepatic ischemia-reperfusion injury (HIRI) frequently occurs as a complication in liver surgeries, which significantly impacting patient outcomes. Sinensetin (SEN) is plant-derived polymethoxylated flavone with anti-inflammatory and anti-oxidative activities. However, the hepatoprotective effect of sinensetin HIRI pathogenesis have not been fully explored. Methods We constructed model mice, blood samples collected at 6 24 h after reperfusion to evaluate injury. also evaluated protective mice I/R through histopathological observation, enzyme activity, immunofluorescence, Western blot, molecular docking, pharmacology experiments. Results In our study, we successfully established mouse model, function indicators such ALT, AST LDH were increased group, while SEN pretreatment could lead significant decrease these enzymatic activities, especially perfusion h. addition, hepatocytic necrosis lipid deposition improved under conditions compared group alone. Meanwhile, can increase expression genes related inflammation, concentration-dependent genes. Besides, level apoptosis apoptosis-related BAX Bcl-2 reduced high concentration antioxidant activities CAT GSH-Px showed similar changes. Moreover, dynamic changes key involved endoplasmic reticulum (ER) stress signaling, distribution GRP78 CHOP proteins cells + L-SEN H-SEN groups. Molecular docking simulation theoretical binding between SEN-GRP78 SEN-IRE1α three-dimensional structures. Ultimately, use 4-PBA pharmacologically inhibit ER may substantially reduce damage caused by mice. Conclusion Taken together, results suggested that alleviate suppressing GRP78/CHOP-mediated stress, provide novel therapeutic strategy for treating clinical practice.

Language: Английский

Citations

0
Ovarian toxicity of 2,6-di-tert-butyl-hydroxytoluene on female Ruditapes philippinarum: reproductive endocrine disruption and oxidative stress DOI
Xin Zheng, Xiaohui Li,

Ruicheng Qi

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: unknown, P. 138289 - 138289

Published: April 1, 2025

Language: Английский

Citations

0
Investigation of the Antioxidant and Cellular Toxicity Activities of Gold Nanoparticles Synthesized Using <i>Cichorium Intybus</i> Extract on a Liver Cancer Cell Line DOI Creative Commons

Mohammad Mohammad-Alizadeh,

Ahmad Asgharzadeh, Maryam Tatari

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: 24(1)

Published: April 14, 2025

Background: Liver cancer is increasing in different parts of the world and fourth leading cause death globally. Objectives: The present study aims to synthesize analyze characterization gold nanoparticles (AuNPs) synthesized by Cichorium intybus extract evaluate their antioxidant cellular toxicity activity against liver cells (HepG2). Methods: AuNPs were characterized using X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), fourier-transform infrared spectroscopy (FTIR). was assessed DPPH test, cytotoxicity analyzed MTT method. Results: results indicate that are crystalline materials with a particle size less than 100 nm, mean 23.94 nm. FTIR reveals presence biochemical groups act as reducing factors. demonstrate increases concentration, 87% inhibition free radical scavenging observed at 250 µg/mL. Cell cell lines (HepG2) demonstrated significant time- dose-dependent manner. percentage viability concentration 1000 µg/ml after 24, 48, 72 hours determined be 45%, 51%, 22%, respectively. Conclusions: revealed simple cost-effective environmentally friendly method could employed from food pharmaceutical industries.

Language: Английский

Citations

0
Impact of polystyrene microplastics (PS-MPs) on the entire female mouse reproductive cycle: Assessing reproductive toxicity of microplastics through in vitro follicle culture DOI

Jukyeong Jeong,

Mai Thi Quynh Nhu, Byoung-San Moon

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 297, P. 118228 - 118228

Published: May 1, 2025

Language: Английский

Citations

0
Micro-nanoplastics pollution and mammalian fertility: a systematic review and meta-analysis DOI Creative Commons

Alessandro Marino Volsa,

Eleonora Iacono, Barbara Merlo

et al.

Theriogenology, Journal Year: 2025, Volume and Issue: 238, P. 117369 - 117369

Published: Feb. 26, 2025

Language: Английский

Citations

0
Microplastic pollution: Critical analysis of global hotspots and their impact on health and ecosystems DOI
Veeramuthu Ashokkumar,

V.P. Chandramughi,

Kaustubha Mohanty

et al.

Journal of Environmental Management, Journal Year: 2025, Volume and Issue: 381, P. 124995 - 124995

Published: April 7, 2025

Language: Английский

Citations

0
Organ-specific lithium accumulation and its toxic effects on female reproduction DOI

Qigang Fan,

Yi Sun, Qikun Shen

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: unknown, P. 138516 - 138516

Published: May 1, 2025

Language: Английский

Citations

0
Health effects of synthetic additives and the substitution potential of plant-based additives DOI
Jiaqi Chen, Pengguo Xia

Food Research International, Journal Year: 2024, Volume and Issue: 197, P. 115177 - 115177

Published: Oct. 5, 2024

Language: Английский

Citations

1