Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 286, P. 117095 - 117095
Published: Oct. 11, 2024
Language: Английский
BMJ Open, Journal Year: 2025, Volume and Issue: 15(2), P. e095210 - e095210
Published: Feb. 1, 2025
Objectives This study aims to systematically assess the global, regional, and national burden of asthma attributable nitrogen dioxide (NO₂) pollution. Design setting Analysis population-level data from 1990 2021 obtained Global Burden Disease Study 2021, covering 204 countries territories. Participants included patients with NO₂ Main outcomes measures Asthma-related disability-adjusted life-years (DALYs) age-standardised DALY rates (ASDR) pollution across The estimated annual percentage change (EAPC) was used temporal trends identify regions increasing or decreasing burdens. Results In contributed approximately 176.73 thousand DALYs globally, an ASDR 2.48 per 100 000 population (95% uncertainty interval (UI) −2.26 10.30). global declined significantly EAPC −1.93% CI −2.14% −1.72%). High-income North America had highest (10.74 000; 95% UI 10.12 46.56), while Australasia experienced most significant reduction in over period (EAPC −3.92%; −4.46% −3.37%). contrast, Oceania Southeast Asia showed burden, EAPCs 2.33% 1.57% 3.10%) 1.14% 0.81% 1.47%), respectively. 5–9 age group carried reflecting vulnerability younger children exposure. A positive correlation between sociodemographic index (SDI) observed (R=0.637, p<0.001), indicating a greater higher SDI regions. Conclusion findings highlight regional demographic disparities Tailored public health strategies are needed address rising vulnerable Future research should focus on identifying effective interventions reduce exposure improve outcomes, especially rapidly developing areas.
Language: Английский
Citations
0
International Journal of Environmental Health Research, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 14
Published: Feb. 15, 2025
Exposure to fine particulate matter (PM2.5) is a significant risk factor for asthma, promoting airway inflammation and oxidative stress. This study evaluates Nobiletin's (NOB) efficacy in mitigating lung damage asthma-induced mice exposed PM2.5. Using an ovalbumin (OVA) plus PM2.5-induced asthma model BALB/c mice, we investigated the therapeutic impacts of NOB compared dexamethasone (DEX). significantly moderated index values inflammatory markers without affecting body weight. Notably, enhanced Nrf2 expression decreased NF-κB-p65, IKK, Keap-1 levels, aligning with reductions malondialdehyde (MDA) reactive oxygen species (ROS) while increasing superoxide dismutase (SOD) glutathione peroxidase (GPx) activities. These findings suggest that can effectively reduce by modulating NF-κB/Nrf2 signaling pathways.
Language: Английский
Citations
0
Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 490, P. 137796 - 137796
Published: Feb. 28, 2025
Language: Английский
Citations
0
Journal of Asthma, Journal Year: 2024, Volume and Issue: 61(12), P. 1601 - 1610
Published: July 2, 2024
Objective: This systematic review aimed to investigate the epidemiological data about meteorological factors and climate change (CC) impact on asthma.
Language: Английский
Citations
1
Frontiers in Allergy, Journal Year: 2024, Volume and Issue: 5
Published: Dec. 6, 2024
The relationship of asthma with humidity and precipitation remains controversial. objective this study was to investigate the association increased risk.
Language: Английский
Citations
0
Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 286, P. 117095 - 117095
Published: Oct. 11, 2024
Language: Английский
Citations
0