Enviromental endocrine disruptor risks in the central nervous system: Neurotoxic effects of PFOS and glyphosate

Environmental Toxicology and Pharmacology, Journal Year: 2024, Volume and Issue: 109, P. 104496 - 104496

Published: July 2, 2024

Endocrine disruptors (EDs) pose significant risks to human and environmental health, with potential implications for neurotoxicity. This study investigates the synergistic neurotoxic effects of perfluorooctane sulfonate (PFOS) glyphosate (GLY), two ubiquitous EDs, using SHSY5Y neuronal C6 astrocytic cell lines. While individual exposures PFOS at non-toxic concentrations did not induce changes, their combination resulted in a marked increase oxidative stress neuroinflammatory responses. Specifically, co-exposure led elevated levels interleukin-6, tumor necrosis factor alpha, interferon gamma, along reduced interleukin-10 expression, indicative heightened processes. These findings underscore importance considering interactions EDs assessing highlight urgent need further research mitigate adverse these compounds on neurological health.

Language: Английский

Occurrence of Per- and polyfluoroalkyl substances in Wheat, Maize, Rice, and Soybean from Chinese Major Grain Producing Regions

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 480, P. 136509 - 136509

Published: Nov. 14, 2024

Language: Английский