Cells, Journal Year: 2024, Volume and Issue: 13(24), P. 2106 - 2106

Published: Dec. 19, 2024

The knowledge of comparative and developmental immunobiology has grown over the years been strengthened by contributions multi-omics research. High-performance microscopy, flow cytometry, scRNA sequencing, increased capacity to handle complex data introduced machine learning have allowed uncovering aspects great complexity diversity in invertebrate immunocytes, i.e., immune-related circulating cells, which until a few ago could only be described terms morphology basic cellular functions, such as phagocytosis or enzymatic activity. Today, immunocytes are recognized sophisticated biological entities, involved host defense, stress response, wound healing, organ regeneration, but also numerous functional organismal life not directly related embryonic development, metamorphosis, tissue homeostasis. multiple functions do always fit description organisms simplified systems compared those represented vertebrates. However, precisely increasing revealed makes increasingly suitable models for addressing biologically significant specific questions, while continuing present undeniable advantages associated with their ethical economic sustainability.

Language: Английский