Stereoselective effects and its potential mechanism of ofloxacin on the growth and development of Rana nigromaculata: mainly liver lipid metabolism

Frontiers of Environmental Science & Engineering, Journal Year: 2025, Volume and Issue: 19(4)

Published: Feb. 20, 2025

Language: Английский

Study on the Toxicological Impacts of Intraperitoneal Microcystin-LR Injection on GIFT Tilapia (Oreochromis niloticus) Through Multi-Omics Analysis

Antioxidants, Journal Year: 2025, Volume and Issue: 14(3), P. 296 - 296

Published: Feb. 28, 2025

This study employed multi-omics analysis to systematically evaluate the toxic effects of intraperitoneal injection MC-LR on GIFT tilapia. The results showed that 96 h post injection, serum levels aspartate GOT, GPT, LYZ, T-AOC, and SOD significantly decreased (p < 0.05). In contrast, hepatic CAT MDA increased. 16S rDNA sequencing method revealed a significant reduction in α diversity intestinal microbiota. At phylum level, relative abundances Firmicutes Bacteroidota decreased; at genus several genera, including Bacteroides Pseudomonas, also exhibited changes. Functional prediction indicated affected pathways were primarily related metabolism disease. Additionally, targeted metabolomics decrease SCFAs, such as butyric acid. Correlation further elucidated complex interactions between microbiota, biochemical indicators, SCFA metabolism. Overall, demonstrated induced oxidative stress liver damage led microbiota imbalance metabolic dysfunction

Language: Английский

Highly efficient photocatalytic Microcystin-LR elimination using magnetic recyclable nanocomposite ZnO/Fe3O4/Bi2WO6/RGO and its toxicity assessment

Journal of environmental chemical engineering, Journal Year: 2024, Volume and Issue: unknown, P. 115161 - 115161

Published: Dec. 1, 2024

Language: Английский