Cited by Network toxicological and molecular docking in investigating the mechanisms of toxicity of agricultural chemical pyraclostrobin

Occurrence, processing factors, and dietary risk assessment of multi-pesticides in cowpea DOI

Kunyu Wang, Mingyu Liu, Tongtong Wang

et al.

Food Control, Journal Year: 2025, Volume and Issue: unknown, P. 111145 - 111145

Published: Jan. 1, 2025

Language: Английский

Citations

Pyraclostrobin-induced toxic effects in the gills of common carp (Cyprinus carpio L.): Mechanisms unveiled through biochemical, molecular, and metabolomic analyses DOI

Haoyang Zhao,

Qingping Ma,

Shuhan Lu

et al.

Comparative Biochemistry and Physiology Part D Genomics and Proteomics, Journal Year: 2025, Volume and Issue: 54, P. 101443 - 101443

Published: Feb. 11, 2025

Language: Английский

Citations

ADB-FUBINACA-induced developmental toxicity, neurotoxicity, and cardiotoxicity in embryonic zebrafish (Danio rerio) DOI

Yuanzhao Wu,

Fenliang Fan, Lu Zhou

et al.

Environmental Research, Journal Year: 2025, Volume and Issue: unknown, P. 121517 - 121517

Published: April 1, 2025

Language: Английский

Citations

3,3′,5,5′-Tetrabromobiphenyl (BB-80) and Its Hydroxylation Product (OH-BB-80) Mediate Immunotoxicity and Inhibit Embryonic Development in Zebrafish (Danio rerio) via the TLR4/NF-κB Signaling Pathway DOI

Yongjian Shao,

Yinan Zhang, Xiaofang Zhang

et al.

Toxics, Journal Year: 2025, Volume and Issue: 13(4), P. 293 - 293

Published: April 10, 2025

Polybrominated biphenyls (PBBs) are metabolically transformed into monohydroxylated PBBs (OH-PBBs) in the environment and living organisms. Although OH-PBBs pose a significant health threat to organisms, little is known about immunotoxicity of OH-PBBs. Therefore, objectives this study were validate BB-80 OH-BB-80 induced explore associated pathway mechanisms. Early development zebrafish (Danio rerio) larvae was inhibited by 10 μg/L OH-BB-80, as indicated negative changes developmental indices. oxidative stress, significantly up-regulated reactive oxygen species (ROS) nitrogen (RNS), activated antioxidant enzyme system at μg/L. The mRNA expression levels inflammatory cytokines chemokines up-regulated, indicative onset inflammation after exposure. In addition, downregulation toll-like receptor 4 (TLR4), MyD88, NF-κB pathway-related genes observed, suggesting that target TLR/NF-κB signaling pathway. Molecular docking data showed bound stably TLR4. Taken together, mediate early suppression with TLR4/NF-κB Our results further understanding BB-80- OH-BB-80-induced immunotoxicity, highlighting need for toxicological studies examine toxic effects transformation products PBBs.

Language: Английский

Citations

Network toxicological and molecular docking in investigating the mechanisms of toxicity of agricultural chemical pyraclostrobin DOI

S.W. Li,

Xudong Tian,

Jin-Kun Song

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 297, P. 118244 - 118244

Published: April 27, 2025

Language: Английский

Citations