Community-based insights into the connection between endocrine-disrupting chemicals and depressive symptoms

Current Research in Toxicology, Journal Year: 2025, Volume and Issue: 8, P. 100225 - 100225

Published: Jan. 1, 2025

Language: Английский

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Phthalates and Non-Phthalate Plasticizers and Thyroid Dysfunction: Current Evidence and Novel Strategies to Reduce Their Spread in Food Industry and Environment

Toxics, Journal Year: 2025, Volume and Issue: 13(3), P. 222 - 222

Published: March 19, 2025

Thyroid hormones (THs) play a crucial role in various biological functions, including metabolism, cell growth, and nervous system development, any alteration involving the structure of thyroid gland TH secretion may result disease. Growing evidence suggests that phthalate plasticizers, which are commonly used wide range products (e.g., food packaging materials, children’s toys, cosmetics, medical devices), can impact function, primarily affecting serum levels THs TH-related gene expression. Like compounds, recently introduced alternative plasticizers leach from their source material into environment, particularly foods, although so far only very limited number studies have investigated toxicity. This review aimed at summarizing current knowledge on non-phthalate dysfunction disease, describing major mechanisms underlying this relationship. We will also focus industry as one main players for massive spread such compounds human body, turn conveyed by edible compounds. Given increasing worldwide use essential humans, novel strategies should be envisaged to reduce burden and, general, health.

Language: Английский

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Organochlorine pesticides: occurrence and spatial distribution of residues, toxicity, and toxic mechanisms

Toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 154134 - 154134

Published: April 1, 2025

Language: Английский

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Insight into the Potential Mechanisms of Endocrine Disruption by Dietary Phytoestrogens in the Context of the Etiopathogenesis of Endometriosis

Published: June 30, 2023

Phytoestrogens (PEs) are estrogen-like nonsteroidal compounds derived from plants (e.g., nuts, seeds, fruits and vegetables) fungi that structurally similar to 17β-estradiol. PEs bind all types of estrogen receptors, including ERα ERβ the nuclear a membrane-bound receptor known as G protein-coupled (GPER). As endocrine-disrupting chemicals (EDCs) with pro‐ or antiestrogenic properties, can potentially disrupt hormonal regulation homeostasis, resulting in developmental reproductive abnormalities. However, lack diet does not result development deficiency symptoms. To properly assess benefits risks associated use PE-rich diet, it is necessary distinguish between endocrine disruption (endocrine-mediated adverse effects) nonspecific effects on system. Endometriosis an estrogen-dependent disease unknown etiopathogenesis, which tissue lining uterus (the endometrium) grows outside subsequent complications being manifested local inflammatory reactions. affects 10–15% women age chronic pelvic pain, dysmenorrhoea, dyspareunia infertility. In this review, endocrine-disruptive actions reviewed context endometriosis determine whether has positive negative effect risk course endometriosis.

Language: Английский

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Relationship between serum thyroid hormones and their associated metabolites, and gene expression bioindicators in the back skin of Rana [Lithobates] catesbeiana tadpoles and frogs during metamorphosis

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 13

Published: Jan. 18, 2023

Anuran metamorphosis is characterized by profound morphological changes including remodeling of tissues and organs. This transition initiated thyroid hormones (THs). However, the current knowledge changing levels THs during relies on pooled samples using methods known for high variability with sparse reporting measured variation. Moreover, establishing a clear linkage between key gene expression bioindicators TH throughout metamorphic process needed. Using state-of-the-art ultra-high performance liquid chromatography isotope-dilution tandem mass spectrometry, we targeted 12 metabolites in serum Rana [Lithobates] catesbeiana (n=5-10) across seven distinct postembryonic stages beginning premetamorphic tadpoles (Gosner stage 31-33) continuing through to juvenile frog 46). were related TH-relevant transcripts (thra, thrb, thibz) back skin same individual animals. Significant increases from basal observed thyroxine (T4) 3,3',5-triiodothyronine (T3) at Gosner 41, reaching maximal 44 (28 ± 10 2.3 0.5 ng/mL, respectively), decreasing frogs. In contrast, 3,5-diiodothyronine (T2) increased significantly 40 was maintained elevated until 44. While thra transcript remained constant then decreased end climax, thrb thibz induced followed decrease froglet. exemplifies exquisite timing events as classic early response genes are transcribed anticipation peak concentrations. The T2 concentration profile suggests biological role this biomolecule anuran development an additional aspect that may be target anthropogenic chemicals can disrupt signalling. Hence, second aim study, set out find metamorphosis, which aid future investigations developmental disruption. sensitive nanoLC-Orbitrap system untargeted analysis workflow applied. Among 6,062 endogenous metabolites, 421 showed metamorphosis-dependent dynamics. These potential included several carnitines, prostaglandins some steroid hormones.

Language: Английский

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