Association between organophosphorus insecticides exposure and the prevalence of sleep problems in the US adults: An analysis based on the NHANES 2007–2018

Ecotoxicology and Environmental Safety, Journal Year: 2023, Volume and Issue: 255, P. 114803 - 114803

Published: March 22, 2023

The aim of this study was to evaluate the association between organophosphorus pesticides (OPPs) exposure and sleep problems. In study, data from 6295 participants aged 18 years or older were collected National Health Nutrition Examination Survey (NHANES). dialkyl phosphate compounds (DAPs) metabolites, OPPs biomarker, examined using solid phase extraction-high coupled with isotope dilution-ultrahigh performance liquid chromatography-tandem mass spectrometry. Data on short duration (SSD), self-reported trouble sleeping disorder database. Weighted generalized logistic model, weighted quantile sum (WQS) quantile-based g calculation (QGC) methods used for analyzing data. prevalence SSD, in 28.91 % (1814/6274), 25.31 (1593/6294), 9.05 (289/3195), respectively. After confounding factors adjustments, SDD high log-transformed DETP, DMTP, DEDTP, DMDTP 1.19 times (OR: 1.11–1.28, P < 0.001), 1.09 1.03–1.15, = 0.003), 1.26 1.17–1.37, 0.0001), 1.10 1.04–1.17, 0.003) than low showed, A non-linear relationship noted SSD urinary concentration DEP (P nonlinearity DMP DMTP 0.006), 0.001). WQS results showed that 1.28 (95 CI: 1.17–1.40, 0.001) higher co-exposure those co-exposure, DEDTP having enormous weights (0.50). QGC also revealed a significant positive DAPs 1.08, 95 CI:1.02–1.16, 0.01) DETP most weight (0.44). As self-report disorder, only detected it positively associated all adjusted 1.17; 1.07–1.29, However, have not sleeping. Besides, there no disorder. indicated levels single mixture DAP, indicating exposure, an increased general adults, which has implications preventing pollution protecting health.

Language: Английский

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Combined exposure to multiple metals on hypertension in NHANES under four statistical models

Environmental Science and Pollution Research, Journal Year: 2023, Volume and Issue: 30(40), P. 92937 - 92949

Published: July 27, 2023

Language: Английский

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Association between Exposure to Volatile Organic Compounds and the Prevalence of Sleep Problems in US Adults

Toxics, Journal Year: 2024, Volume and Issue: 12(3), P. 222 - 222

Published: March 18, 2024

Background: While mounting evidence suggests a connection between environmental contaminants and sleep problems, it remains uncertain whether exposure to volatile organic compounds (VOCs) specifically is associated with such problems. Methods: Data from the National Health Nutrition Examination Survey program’s five survey cycles (2005–2006, 2011–2018) were used conduct cross-sectional research. on short duration (SSD) self-reported trouble sleeping collected questionnaire data. urine VOCs gathered laboratory The association urinary problems was examined using weighted generalized linear models restricted cubic spline (RCS), quantile sum (WQS), quantile-based g-calculation (QGC) methods. Results: In all, total of 4131 general adult individuals included in this study. prevalence SSD 34.11% 25.03%, respectively. 3,4-MHA, AAMA, AMCC, SBMA, MA risk factors for after adjusting several covariates, largest effect being AMCC (OR = 1.47, 95% CI: 1.08, 2.02). Risk issues CEMA, CYMA, DGBMA, 2HPMA, 3HPMA, MA, PGA, having highest impact an OR 1.69 (95% 1.28, 2.22). Both WQS model QGC showed that co-exposure positively sleeping, most influential VOC. Conclusions: According our research, high levels single or mixed are linked higher population United States. Further prospective experimental studies needed future validate these potential relationships explore underlying mechanisms.

Language: Английский

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Human exposure to chromite mining pollution, the toxicity mechanism and health impact

Heliyon, Journal Year: 2024, Volume and Issue: 10(21), P. e40083 - e40083

Published: Nov. 1, 2024

Significant amounts of toxic metal-containing mining waste are produced by chromium activities, along with the production air pollutants. The presence metals in various environmental media including air, water, and soil, their chemical species such as hexavalent chromium, pose major health hazards for both directly exposed workers population residing near areas. Highlighting requirements enhanced protection safety measures, this comprehensive review shed light on global pollution stemming from chromite activities. Based published literature, study also investigated into caused explored probable effects individuals. exposure routes mechanisms metal induced carcinogenicity groups were assessed. Additionally, generated reactive individuals toxicity discussed. Considering these findings, proposed necessity cross-sectional biomonitoring studies involving occupationally operations. anticipated impact is to influence national industry, instigating improvements occupational settings, real-time monitoring, healthcare provisions workers.Graphical abstract

Language: Английский

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Re-thinking the link between exposure to mercury and blood pressure

Archives of Toxicology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 3, 2025

Hypertension or high blood pressure (BP) is a prevalent and manageable chronic condition which significant contributor to the total global disease burden. Environmental chemicals, including mercury (Hg), may contribute hypertension onset development. Hg health concern, listed by World Health Organization (WHO) as top ten chemical of public concern. Most people are exposed some level Hg, with vulnerable groups, Indigenous peoples small-scale gold miners, at higher risk for exposure. We published systematic review meta-analysis in 2018 showing dose–response relationship between exposure hypertension. This critical summarizes biological effects (both organic inorganic form) on underlying mechanisms that facilitate development related outcomes updates association (total concentrations hair) BP outcomes. also evaluated weight evidence using Bradford Hill criteria. There strong inorganic) animal studies convincing contributes causing structural functional changes, vascular reactivity, vasoconstriction, atherosclerosis, dyslipidemia, thrombosis. The vast include impairments antioxidant defense mechanisms, increased ROS production, endothelial dysfunction, alteration renin–angiotensin system. found additional 16 recent epidemiological have reported last 5 years. Strong from shows positive elevated BP. mixed lower levels but suggests can affect even low doses when co-exposed other metals. Further research needed develop robust conversion factors among different biomarkers standardized measures Regulatory agencies should consider adopting 2 µg/g hair cut-off regulation, especially adults older than child-bearing age.

Language: Английский

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Combined exposure to mixed brominated flame retardants on obstructive sleep apnea syndrome in US adults

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 14, 2025

Accumulating research highlights that exposure to serum brominated flame retardants (BFRs) may elevate health risks. The effects of BFRs, both alone and in combination, on obstructive sleep apnea syndrome (OSAS) have not been thoroughly studied. Our main goal was examine the association between individual mixtures BFRs OSAS risk. Data from National Health Nutrition Examination Survey (NHANES) were employed, including 1,341 participants. We included participants with full details OSAS, covariates, 7 types (PBDE28, PBDE47, PBDE99, PBDE100, PBDE153, PBB153, PBDE209). To investigate risk exposure, multivariate logistic regression, weighted quantile sum (WQS) g-computation (QGC), Bayesian kernel machine regression (BKMR) models, restricted cubic splines (RCS) implemented. Serum PBDE28, showed positive correlations toxic effect co-exposure consistently demonstrated through results WQS QGC BKMR models. PBB153 determined be most BFRs. Additionally, RCS model also verified strong non-linear relationship existed PBB153. Findings study prove exerts a deleterious Future large-scale prospective investigations experimental studies are desirable confirm these findings.

Language: Английский

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Association Between Heavy Metals Mixtures and Life’s Essential 8 Score in General US Adults

Cardiovascular Toxicology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 7, 2025

Language: Английский

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Impact of Maternal Exposure to Trace Metal Mixtures on Bone Mineral Density in Children Aged 3–6: Results from the Guangxi Zhuang Birth Cohort, China

Biological Trace Element Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

Language: Английский

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Cobalt exposure was associated with the risk of hepatic steatosis and advanced liver fibrosis based on a cross-sectional study from NHANES

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 293, P. 118003 - 118003

Published: March 1, 2025

Although Emerging evidence suggests the association of environmental factors with hepatic steatosis and fibrosis, relationship between Cobalt exposure fibrosis was not clear. Our study aimed to explore blood level advanced liver diagnosed by vibration controlled transient elastography (VCTE) in US adults. This analyzed data from 3193 individuals participating 2017-2018 National Health Nutrition Examination Surveys. Participants were classified into four groups according quartiles cobalt concentration. Liver stiffness fat content assessed through vibration-controlled (VCTE), including measurements attenuation parameter (CAP). The levels prevalence explored using logistic regression models stratified subgroup analyses. CAP values showed a significant decline across increasing quartiles. highest quartile had 41 % lower risk compared those lowest (odds ratio: 0.59, 95 confidence interval: 0.46-0.76, p < 0.001). However, no existed fibrosis. Subgroup analysis revealed that consistent age, gender body mass index subgroups. negatively steatosis. may be due increased development upon exposure.

Language: Английский

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Heavy Metals and Cardiovascular Health: Uncovering Links and Health Challenges

Journal of Trace Elements in Medicine and Biology, Journal Year: 2025, Volume and Issue: unknown, P. 127648 - 127648

Published: April 1, 2025

Language: Английский

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