ChemistrySelect,
Journal Year:
2024,
Volume and Issue:
9(41)
Published: Oct. 28, 2024
Abstract
Sugars,
as
cryoprotectants,
can
be
added
to
NP
formulations
before
lyophilization
ensure
that
NPs
retain
their
size
during
long‐term
storage.
In
this
study,
mannitol,
glucose,
and
sucrose
were
used
at
different
concentrations
extend
the
storage
time
of
doxorubicin
(DOX)‐loaded
PLGA‐NPs
prepared
using
two
copolymer
ratios
(75
:
25
50
50)
temperatures
(−20,
+4,
+25
°C).
After
lyophilization,
a
glucose
or
concentration
only
5
%
for
DOX‐PLGA‐75
25‐NP
10
DOX‐PLGA‐50
50‐NP
found
prevent
agglomeration
up
4
months
−20
°C.
It
is
noteworthy
after
°C
months,
was
prevented
in
content
both
types.
On
other
hand,
expected,
no
sugar
type
could
The
sizes
encapsulation
efficiencies
(EE%)
221.8±2.20
45.4
221.5±1.31
48.7
25‐NP,
respectively.
Furthermore,
release
profiles
DOX
investigated
by
UV‐Vis
analyses.
DSC
analysis
revealed
present
free
form
amorphous
NPs.
Consequently,
PLGA
have
an
impact
on
stability
loaded
lyophilizates,
DOX‐loaded
with
75
stored
+4
when
combined
appropriate
contents
concentrations,
demonstrating
versatility
these
materials.
Pharmaceutical Development and Technology,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 17
Published: Oct. 11, 2024
Traditional
chemotherapeutic
drugs
lack
optimal
efficacy
and
invoke
severe
adverse
effects
in
cancer
patients.
Polydatin
(PD),
a
phytomedicine,
has
gradually
gained
attention
due
to
its
antitumor
activity.
However,
low
solubility
poor
bioavailability
are
still
cornerstone
issues.
The
present
study
aimed
fabricate
develop
hyaluronic
acid/lactoferrin-double
coated
PD/PLGA
nanoparticles
Communications Biology,
Journal Year:
2024,
Volume and Issue:
7(1)
Published: July 13, 2024
Abstract
This
study
addresses
the
diagnostic
and
therapeutic
challenges
in
malignant
melanoma
(MM)
non-melanoma
skin
cancers
(NMSC).
We
aim
to
identify
circulating
proteins
causally
linked
MM
NMSC
traits
using
a
multicenter
Mendelian
randomization
(MR)
framework.
utilized
large-scale
cis-MR
estimate
impact
of
numerous
plasma
on
MM,
NMSC,
squamous
cell
carcinoma
(SCC),
basal
(BCC).
To
ensure
robustness,
additional
analyses
like
MR
Steiger
Bayesian
colocalization
are
conducted,
followed
by
replication
through
meta-analytical
methods.
The
associations
between
identified
outcomes
also
validated
at
tissue
level
Transcriptome-Wide
Association
Study
Furthermore,
protein-protein
interaction
analysis
is
conducted
explore
relationship
existing
cancer
medication
targets.
has
13
with
BCC,
2
SCC,
1
MM.
Specifically,
ASIP
KRT5
associated
potentially
targeting
CTSS
TNFSF8
as
promising
druggability
candidates
for
BCC.
multidimensional
approach
nominates
ASIP,
KRT5,
CTSS,
potential
targets
cancers.
ChemistrySelect,
Journal Year:
2024,
Volume and Issue:
9(41)
Published: Oct. 28, 2024
Abstract
Sugars,
as
cryoprotectants,
can
be
added
to
NP
formulations
before
lyophilization
ensure
that
NPs
retain
their
size
during
long‐term
storage.
In
this
study,
mannitol,
glucose,
and
sucrose
were
used
at
different
concentrations
extend
the
storage
time
of
doxorubicin
(DOX)‐loaded
PLGA‐NPs
prepared
using
two
copolymer
ratios
(75
:
25
50
50)
temperatures
(−20,
+4,
+25
°C).
After
lyophilization,
a
glucose
or
concentration
only
5
%
for
DOX‐PLGA‐75
25‐NP
10
DOX‐PLGA‐50
50‐NP
found
prevent
agglomeration
up
4
months
−20
°C.
It
is
noteworthy
after
°C
months,
was
prevented
in
content
both
types.
On
other
hand,
expected,
no
sugar
type
could
The
sizes
encapsulation
efficiencies
(EE%)
221.8±2.20
45.4
221.5±1.31
48.7
25‐NP,
respectively.
Furthermore,
release
profiles
DOX
investigated
by
UV‐Vis
analyses.
DSC
analysis
revealed
present
free
form
amorphous
NPs.
Consequently,
PLGA
have
an
impact
on
stability
loaded
lyophilizates,
DOX‐loaded
with
75
stored
+4
when
combined
appropriate
contents
concentrations,
demonstrating
versatility
these
materials.
