Polymeric
based
nanoparticles
are
garnering
significant
interest
for
their
potential
in
drug
delivery.
Specially,
nanopolymers
that
have
been
functionalized
with
molecules,
such
as
proteins
or
peptides,
a
versatile
vehicle
Curcumin
(Cur)
is
one
of
the
most
commonly
studied
anticancer
compounds
and
widely
acknowledged
having
positive
effects
on
human
health.
However,
its
insolubility
low
bio-distribution
greatly
hinder
exploitation
beneficial
traits.
In
this
study,
our
team
created
nano
delivery
system
which
utilized
nanopolymer
called
PCL-PEG
(poly(ε-caprolactone)-poly
(ethylene
glycol)).
This
was
A6
peptide
to
enable
targeted
Cur.
The
designed
advantageous
(NPs),
including
stable
zeta
(–32.7),
small
size
(54.3),
uniform
surface
morphology,
high
hydrophilicity
(13.72°).
addition,
systems
exhibited
encapsulation
efficacy
(93
±
0.89
%),
loading
(16.7
0.9
were
characterized
by
slow
gradual
release
profile
approximately
83.13
0.12%.
MTT
assay
results
showed
formulation
known
Cur-NPs-A6
caused
increase
cell
death
MDA-MB-231
cancer
cells
(IC50
=
23.31
0.85
µM).
did
not
cause
any
harm
noncancerous
MCF-10A
(normal
group).
Furthermore,
both
RT-qPCR
invasion
assays
demonstrated
able
effectively
activate
apoptosis
pathway
inhibit
invasion.
Our
findings
suggest
use
smart
system,
has
affinity
CD44
receptor
-
be
upregulated
numerous
malignant
conditions,
could
highly
efficient
approach
treating
cancer.
Frontiers in Pharmacology,
Journal Year:
2023,
Volume and Issue:
14
Published: Oct. 19, 2023
Introduction:Capparis
cartilaginea
Decne.
(CC)
originates
from
the
dry
regions
of
Asia
and
Mediterranean
basin.
In
traditional
medicine,
tea
CC
leaves
is
commonly
used
to
treat
inflammatory
conditions
such
as
rheumatism,
arthritis,
gout.
Due
limited
studies
on
phytochemistry
biological
activity
compared
other
members
Capparaceae
family,
this
work
aims
to:
1)
Identify
chemical
composition
extract
2)
Investigate
potential
anti-inflammatory
effect
extract,
isolated
compounds.
Methods:
To
guarantee
aim
1,
high-speed
countercurrent
chromatography
(HSCC)
method;
Nuclear
Magnetic
Resonance
(NMR)
High-Performance
Liquid
Chromatography
coupled
Electrospray
Ionisation
Quadrupole
Time-of-Flight
Mass
Spectrometry
(HPLC-ESIQTOF-MS/MS)
were
employed
for
purpose.
2,
we
studied
flavonoids
matrix
metalloproteinases
(MMPs)
-9
-2
in
murine
macrophages.
Molecular
docking
was
initially
performed
assess
binding
affinity
active
site
MMP-9.
Results
discussion:In
silico
model
a
powerful
tool
predict
compounds
that
could
strongly
bind
inhibit
MMPs.
have
shown
possess
significant
antioxidant
effect,
which
can
partially
explain
their
medicinal
use.
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: June 20, 2024
Abstract
Nanotechnology
offers
a
promising
solution
for
overcoming
chemotherapy
challenges
in
cancer
treatment
by
enabling
targeted
drug
delivery.
Moringa
oleifera
Lam.
containing
significant
medicinal
compounds,
is
known
its
anticancer
and
antioxidant
characteristics.
In
this
study,
we
investigated
the
effectiveness
of
polymeric
PLA-PEG-FA/Chitosan-PLA
nanoparticles
on
delivery
plant’s
extract
their
effects
growth
viability
cell
lines.
Aqueous
extracts
were
obtained
from
plant
callus
tissues
M.
oleifera.
A
solvent
diffusion
technique
was
employed
to
prepare
PLA-PEG-FA/PLA-Chitosan
nanoparticles.
The
copolymers
encapsulated
with
moringa
aqueous
extract,
pure
quercetin.
physicochemical
characteristics
evaluated.
Finally,
encapsulation
efficiency,
release,
vitro
cytotoxicity,
apoptosis
analysis
conducted
study
efficiency
MCF-7
BT-549
breast
synthesized
exhibit
spherical
shape
an
average
size
230
nm
zeta
potential
-6.4
mV.
spectrophotometric
assessment
revealed
that
release
more
pronounced
at
acidic
pH.
water-soluble
tetrazolium
salt
(WST-1)
assay
demonstrated
biocompatibility
nanocarriers
low
toxicity.
Furthermore,
highest
percentage
pre-
post-apoptotic
cells
detected
line
treated
PLA-PEG-FA/Chitosan-PLA/Quercetin
(31.2
7.15%,
respectively).
it
concluded
PLA-Chitosan
high
capability
Quercetin,
compounds
present
water
(from
tissue)
towards
cells.
National Journal of Community Medicine,
Journal Year:
2024,
Volume and Issue:
15(12), P. 1090 - 1107
Published: Dec. 1, 2024
Background:
Cancer
treatment
remains
a
critical
area
of
clinical
research,
with
numerous
approaches
developed
depending
on
tumor
type
and
stage.
Recent
advances
in
genetic
immunotherapy,
bioinformatics,
science
have
revolutionized
cancer
diagnosis
treatment.
Emerging
technologies
such
as
gene
delivery,
oncolytic
virotherapy,
suicide
therapy,
CRISPR/Cas9
offer
promising
therapeutic
avenues.
Methods:
This
review
provides
detailed
analysis
the
latest
techniques
Gene
artificial
intelligence,
Nanocarrier
Delivery
Systems,
Immunotherapy,
CAR
T-Cell
Therapy,
Epigenetics,
Vaccines,
Clinical
translation
assessing
their
potential
A
early
studies
focused
integration
nanotechnology,
intelligence
(AI)
therapies
emphasis
targeted
delivery
systems
precision
medicine.
Results:
The
highlights
synergistic
effects
combining
particularly
immune
checkpoint
inhibitors
CAR-T
cell
therapy.
Therapies
demonstrate
significant
targeting,
while
advancements
nanocarrier
enhanced
reduced
side
effects.
AI's
role
improving
personalized
is
also
underscored.
Conclusion:
comprehensive
recent
technological
addresses
gaps
previous
reviews
offers
updated
insights
into
cutting-edge
treatments.
emphasizes
evolving
AI,
providing
clinicians
researchers
most
current
relevant
information
for
optimizing
strategies.
Critical Reviews in Food Science and Nutrition,
Journal Year:
2023,
Volume and Issue:
unknown, P. 1 - 25
Published: Aug. 21, 2023
AbstractNanoencapsulation
has
found
numerous
applications
in
the
food
and
nutraceutical
industries.
Micro
nanoencapsulated
forms
of
bioactives
have
proven
benefits
terms
stability,
release,
performance
body.
However,
encapsulated
ingredient
is
often
subjected
to
a
wide
range
processing
conditions
this
followed
by
storage,
consumption,
transit
along
gastrointestinal
tract.
A
strong
understanding
fate
nanoencapsulates
biological
system
mandatory
as
it
provides
valuable
insights
for
selection,
formulation,
application.
In
addition
their
efficacy,
there
also
need
assess
safety
ingested
nanoencapsulates.
Given
rising
research
commercial
focus
subject,
review
on
interaction
factors
mechanisms,
highlighting
prospective
fate.
This
covers
various
approaches
studying
Also,
with
emphasis
overall
scope,
new
advanced
integrated
common
methodology
evaluate
post-administration
discussed.Keywords:
Nanoencapsulatesbiological
fategastrointestinal
tractsimulated
digestionencapsulationoral
delivery
Additional
informationFundingThe
author(s)
reported
no
funding
associated
work
featured
article.
Scope
Hepatocellular
carcinoma
(HCC)
results
from
various
etiologies,
such
as
Hepatitis
B
and
C,
Alcoholic
Non‐alcoholic
fatty
liver
disorders,
fibrosis,
cirrhosis.
About
80
to
90%
of
HCC
cases
possess
cirrhosis,
which
is
brought
on
by
persistent
inflammation.
TGF‐β
a
multifunctional
polypeptide
molecule
that
acts
pro‐fibrogenic
marker,
inflammatory
cytokine,
immunosuppressive
agent,
pro‐carcinogenic
growth
factor
during
the
progression
HCC.
The
preclinical
clinical
evidence
illustrates
can
induce
epithelial‐to‐mesenchymal
transition,
promoting
hepatocyte
immune
evasion.
Therefore,
targeting
pathway
be
promising
therapeutic
option
against
Methods
Results
We
carry
out
systemic
analysis
eight
potentially
selected
culinary
Indian
spices:
Turmeric,
Black
pepper,
Ginger,
Garlic,
Fenugreek,
Red
Clove,
Cinnamon,
their
bioactives
in
regulation
cancer.
Conclusion
Turmeric
its
active
constituent,
curcumin,
highest
potential
treating
inflammation‐induced
they
also
have
maximum
number
ongoing
in‐vivo
in‐vitro
studies.
ACS Applied Bio Materials,
Journal Year:
2024,
Volume and Issue:
8(1), P. 676 - 687
Published: Dec. 30, 2024
A
multifunctional
nanoplatform
integrating
multiple
therapeutic
functions
may
be
an
effective
strategy
to
realize
satisfactory
efficacy
in
the
treatment
of
tumors.
However,
there
is
still
a
certain
challenge
agents
into
single
formulation
using
simple
method
due
variations
their
properties.
In
this
work,
CuS-ICG@PDA-FA
nanoparticles
(CIPF
NPs)
with
excellent
ability
produce
reactive
oxygen
species
and
photothermal
conversion
performance
are
fabricated
by
gentle
method.
Hollow
mesoporous
copper
sulfide
(HMCuS
not
only
have
loading
but
also
can
cause
highly
efficient
Fenton-like
reaction
for
chemodynamic
therapy
(CDT).
The
loaded
photosensitizer
indocyanine
green
(ICG)
imparts
photodynamic
properties
NPs,
which
turn
enhances
stability
ICG.
polydopamine
(PDA)
coating
improves
biocompatibility
NPs
creates
conditions
surface
modification
folic
acid.
FA-coated
show
precise
targeting
tumor
cells.
results
cellular
uptake
assay
demonstrate
that
CIPF
enter
cells
through
endocytic
pathway.
Lysosome
colocalization
escape
experiments
prove
possess
good
lysosomal
under
irradiation
NIR.
Both
vitro
vivo
antitumor
studies
reveal
photothermal/photodynamic/chemodynamic
therapy.
construction
high-performance
offers
valuable
insights
design
sulfide-based
combined
cancer
theranostics.
Polymeric
based
nanoparticles
are
garnering
significant
interest
for
their
potential
in
drug
delivery.
Specially,
nanopolymers
that
have
been
functionalized
with
molecules,
such
as
proteins
or
peptides,
a
versatile
vehicle
Curcumin
(Cur)
is
one
of
the
most
commonly
studied
anticancer
compounds
and
widely
acknowledged
having
positive
effects
on
human
health.
However,
its
insolubility
low
bio-distribution
greatly
hinder
exploitation
beneficial
traits.
In
this
study,
our
team
created
nano
delivery
system
which
utilized
nanopolymer
called
PCL-PEG
(poly(ε-caprolactone)-poly
(ethylene
glycol)).
This
was
A6
peptide
to
enable
targeted
Cur.
The
designed
advantageous
(NPs),
including
stable
zeta
(–32.7),
small
size
(54.3),
uniform
surface
morphology,
high
hydrophilicity
(13.72°).
addition,
systems
exhibited
encapsulation
efficacy
(93
±
0.89
%),
loading
(16.7
0.9
were
characterized
by
slow
gradual
release
profile
approximately
83.13
0.12%.
MTT
assay
results
showed
formulation
known
Cur-NPs-A6
caused
increase
cell
death
MDA-MB-231
cancer
cells
(IC50
=
23.31
0.85
µM).
did
not
cause
any
harm
noncancerous
MCF-10A
(normal
group).
Furthermore,
both
RT-qPCR
invasion
assays
demonstrated
able
effectively
activate
apoptosis
pathway
inhibit
invasion.
Our
findings
suggest
use
smart
system,
has
affinity
CD44
receptor
-
be
upregulated
numerous
malignant
conditions,
could
highly
efficient
approach
treating
cancer.
