Deleted Journal,
Journal Year:
2023,
Volume and Issue:
1(1), P. 267 - 267
Published: Dec. 2, 2023
Toxicology
has
extensively
evolved
with
the
study
of
how
external
agents
impact
living
organisms.
This
manuscript
examines
exposome,
a
paradigm
representing
all
environmental
exposures
human
encounter
from
conception
onward,
introducing
holistic
approach
to
understanding
these
effects
on
health.
First
coined
by
Dr.
Christopher
Wild
in
2005,
recent
interpretations
Miller
and
Jones
emphasize
not
only
factors
but
also
behavioral
influences,
internal
biochemical
processes,
implications
microbiome.
These
augmentations
underscore
body’s
dynamic
responses
continuous
adjustments
challenges.
Traditional
toxicology,
which
primarily
focused
singular
compounds,
often
overlooked
intricate
interplays
between
multifaceted
exposures;
exposome
aims
bridge
this
gap.
To
analyze
vast
spectrum
lifetime
exposures,
various
state-of-the-art
techniques
are
use,
such
as
untargeted
high-resolution
mass
spectrometry,
biobanking,
biomonitoring,
diverse
omics
approaches
(metabolomics,
adductomics,
proteomics,
transcriptomics).
methods
empower
scientists
uncover
unknown
risks,
offering
insights
into
complex
nexus
health
outcomes.
World Journal of Advanced Research and Reviews,
Journal Year:
2023,
Volume and Issue:
20(3), P. 1420 - 1434
Published: Dec. 24, 2023
This
study
explores
the
transformative
role
of
artificial
intelligence
(AI)
in
environmental
health
and
public
safety
within
USA,
focusing
on
pollution
monitoring,
emergency
response,
sustainable
practices
for
public.
With
growing
challenges
posed
by
climate
change,
pollution,
emerging
threats,
integration
Artificial
Intelligence
strategies
has
become
imperative.
comprehensive
review
diverse
array
AI
applications
implemented
United
States
to
address
issues
enhance
measures.
The
paper
analyzes
multifaceted
across
various
domains,
including
air
water
quality
disease
surveillance,
disaster
infrastructure
resilience.
advancements
technologies
that
have
revolutionized
data
collection,
analysis,
prediction
are
examined.
Machine
learning
algorithms,
sensor
networks,
satellite
imagery
examined
as
tools
real-time
monitoring
early
detection
hazards.
Additionally,
investigates
surveillance
systems,
showcasing
how
predictive
analytics
data-driven
models
contribute
identification
containment
infectious
diseases.
Furthermore,
sheds
light
incorporation
management,
emphasizing
modeling
risk
assessment
optimizing
response
strategies.
implementation
smart
city
intelligent
systems
is
discussed,
highlighting
contributes
enhancing
minimizing
impact
natural
disasters.
also
critically
evaluates
ethical,
legal,
privacy
considerations
associated
with
widespread
adoption
initiatives.
It
addresses
concerns
related
security,
algorithmic
biases,
need
transparent
accountable
governance
frameworks.
Through
an
in-depth
analysis
case
studies,
policies,
initiatives,
this
provides
insights
into
successes
USA.
concludes
recommendations
future
research
directions
policy
ensure
responsible
effective
safeguarding
safety.
findings
presented
broader
discourse
leveraging
resilient
communities
face
evolving
challenges.
Sustainability,
Journal Year:
2024,
Volume and Issue:
16(7), P. 2830 - 2830
Published: March 28, 2024
This
study
explores
how
the
layout
of
neighborhoods
in
traditional
settlements
Saudi
Arabia’s
Najdi
region
influence
social
interactions
and
urban
planning
decisions.
The
uses
a
multidisciplinary
approach
that
includes
morphology,
architectural
phenomenology,
sociological
methods
to
investigate
relationships
between
spatial
organization
decision-making
processes
on
both
macro
micro
levels
decision-making.
purpose
is
look
at
collective
action
affect
fabric
norms
different
levels.
applies
case
analysis
approaches
settlements’
structure
promotes
peace
among
inhabitants
while
also
sustaining
cultural
traditions.
qualitative
investigates
arrangements
behaviors,
developing
better
understanding
residents
interact
with
their
surroundings.
According
study’s
findings,
these
layouts
sustain
customs
assist
communities
adapting
environmental
changes
by
retaining
activities.
identifies
significance
balancing
development
retention
important
values
implementation
long-term
conservation
plans.
Traditional
towns
can
serve
as
design
examples,
emphasizing
need
acknowledge
distinct
value
vernacular
architecture
modern
fostering
cohesion.
Environmental Science & Technology,
Journal Year:
2024,
Volume and Issue:
58(17), P. 7256 - 7269
Published: April 19, 2024
Through
investigating
the
combined
impact
of
environmental
exposures
experienced
by
an
individual
throughout
their
lifetime,
exposome
research
provides
opportunities
to
understand
and
mitigate
negative
health
outcomes.
While
current
is
driven
epidemiological
studies
that
identify
associations
between
effects,
new
frameworks
integrating
more
substantial
population-level
metadata,
including
electronic
administrative
records,
will
shed
further
light
on
characterizing
exposure
risks.
Molecular
biology
offers
methods
concepts
study
biological
impacts
exposomes
in
experimental
computational
systems.
Of
particular
importance
growing
use
omics
readouts
clinical
studies.
This
paper
calls
for
adoption
mechanistic
molecular
approaches
as
essential
step
understanding
genotype
interactions
underlying
human
phenotypes.
A
series
recommendations
are
presented
make
necessary
appropriate
steps
move
from
association
causation,
with
a
huge
potential
inform
precision
medicine
population
health.
includes
establishing
hypothesis-driven
laboratory
testing
within
field,
supported
read
across
model
systems
human.
Social Science & Medicine,
Journal Year:
2024,
Volume and Issue:
354, P. 117056 - 117056
Published: June 15, 2024
Contemporary
research
on
the
exposome,
i.e.
sum
of
all
exposures
an
individual
encounters
throughout
life
and
that
may
influence
human
health,
bears
promise
integrative
policy-relevant
effect
environment
health.
Critical
analyses
first
generation
exposome
projects
have
voiced
concerns
over
their
actual
breadth
inclusion
environmental
factors
a
related
risk
molecularization
public
health
issues.
The
emergence
European
Human
Exposome
Network
(EHEN)
provides
opportunity
to
better
situate
ambitions
priorities
approach
basis
new
ongoing
research.
We
assess
promises,
methods,
limitations
EHEN,
as
case
study
second
A
critical
textual
analysis
profile
articles
from
each
involved
in
published
Environmental
Epidemiology,
was
carried
out
derive
common
priorities,
innovations,
methodological
conceptual
choices
across
EHEN
discuss
it.
consolidates
its
outlook
by
reinforcing
volume
variety
data,
data
infrastructure
diversifying
strategies
deliver
actionable
knowledge.
Yet
data-driven
severely
restrict
geographical
political
scope
this
knowledge
issues
primarily
urban
setups,
which
aggravate
some
socio-spatial
inequalities
Europe.
doubles
down
initial
ambition
effects
fuel
interventions.
This
intensification
is,
however,
accompanied
significant
epistemological
challenges
doesn't
help
overcome
severe
restrictions
thus
advocate
for
increased
reflexivity
conceptually
methodologically
Environmental Research,
Journal Year:
2023,
Volume and Issue:
233, P. 116452 - 116452
Published: June 18, 2023
Background
The
exposome
approach
can
be
a
powerful
tool
for
understanding
the
intertwining
of
social,
physical,
and
internal
influences
that
shape
mental
health
cognitive
development
throughout
childhood.
To
distil
conceptual
models
subsequent
analyses,
EU-funded
project
Early
Environmental
quality
Life-course
effects
(Equal-Life)
has
conducted
literature
reviews
on
potential
mediators
linking
to
these
outcomes.
We
report
scoping
review
model
role
restorative
possibilities
physical
activity.
Methods
Peer-reviewed
studies
published
since
year
2000
in
English,
association
between
health/cognition
children/adolescents,
quantitatively
investigating
restoration/restorative
as
mediating
variable
were
considered.
Database
searches
last
updated
December
2022.
used
an
unstructured
expert-driven
fill
gaps
reviewed
literature.
Results
Five
records
three
distinct
identified,
indicating
scarcity
empirical
evidence
this
newly
developing
research
area.
Not
only
few
numbers,
but
also
cross-sectional,
lending
tentative
support
idea
perceived
adolescent's
living
environment
might
mediate
greenspace
health.
Physical
activity
emerged
mediator
leading
better
psychological
outcomes
environments.
provide
critical
discussion
caveats
when
restoration
mechanism
children
propose
hierarchical
including
restoration,
activity,
relational
dynamics
their
environment,
social
context,
well
environments
other
than
nature.
Conclusions
It
is
justified
further
explore
early-life
health/cognitive
development.
important
consider
child
perspective
specific
methodological
caveats.
Given
evolving
definitions/operationalizations,
Equal-Life
will
attempt
gap
Journal of Affective Disorders,
Journal Year:
2024,
Volume and Issue:
358, P. 70 - 78
Published: April 30, 2024
Adolescent
mental
health
problems
impose
a
significant
burden.
Exploring
evolving
social
environments
could
enhance
comprehension
of
their
impact
on
health.
We
aimed
to
depict
the
trajectories
neighborhood
exposome
from
middle
late
adolescence
and
assess
intricate
relationship
between
them
adolescent
Participants
(n
=
3965)
FinnTwin12
cohort
with
completed
questionnaires
at
age
17were
used.
Nine
measures
were
assessed.
The
comprised
28
indicators.
Trajectories
these
indicators
ages
12
17
summarized
via
latent
growth
curve
modeling
into
factors,
including
baseline
intercept.
Mixture
effects
all
factors
assessed
through
quantile-based
g-computation.
Repeated
generalized
linear
regression
identified
factors.
Sex
stratification
was
performed.
linear-quadratic
model
most
optimal
trajectory
model.
No
mixture
effect
detected.
Regression
models
showed
some
saliently
linked
p-factor,
internalizing
problems,
anxiety,
hyperactivity,
aggression.
majority
intercepts.
Quadratic
about
mother
tongues
correlated
anxiety
among
sex-combined
participants
males.
factor
in
proportion
households
couples
without
children
associated
females.
limited
only
neighborhood-level
exposures,
multilevel
contextual
situation
interfered
our
assessment.
modestly
influenced
Tackling
root
causes
inequalities
targeted
programs
for
living
conditions
improve
Psychosomatic Medicine,
Journal Year:
2024,
Volume and Issue:
86(5), P. 360 - 365
Published: May 8, 2024
ABSTRACT
The
“geroscience
hypothesis”
posits
that
slowing
the
physiological
processes
of
aging
would
lead
to
delayed
disease
onset
and
longer
healthspan
lifespan.
This
shift
from
a
focus
on
solely
treating
existing
process
is
toward
prevention,
including
risk
factors
found
in
social
environment.
Although
geroscience
traditionally
has
focused
molecular
cellular
drivers
biological
aging,
more
fundamental
causes
may
be
exposome—the
complex
array
human
environmental
exposures
shape
health
disease.
exposome
interact
with
accelerate
biology.
In
this
commentary,
we
review
potential
these
insights
emerging
field
translational
geroscience.
articles
special
issue
highlight
how
stress
determinants
are
associated
biomarkers
such
as
inflammation,
epigenetic
clocks,
telomeres,
spotlight
promising
interventions
mitigate
stress-related
inflammation.
For
incorporate
into
its
agenda,
studies
needed
elucidate
quantify
effects
consider
intervention
targets.
life
course
perspective
allows
us
measure
both
biology
over
time
sensitive
periods
development
major
transitions.
addition,
given
rapid
changes
measurement
biology,
which
include
machine
learning
techniques,
multisystem
phenotypes
being
developed
better
reflect
whole
body
replacing
reliance
single
system
biomarkers.
expanded
integrated
geroscience,
strategies
targeting
hold
promise
for
achieving
equity
extending
healthy
longevity.
Journal of Urban Health,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 14, 2025
Abstract
Chronological
age
is
not
an
accurate
predictor
of
morbidity
and
mortality
risk,
as
individuals’
aging
processes
are
diverse.
Phenotypic
acceleration
(PhenoAgeAccel)
a
validated
biological
measure
incorporating
chronological
biomarkers
from
blood
samples
commonly
used
in
clinical
practice
that
can
better
reflect
aging-related
risk.
The
heterogeneity
age-related
decline
random,
environmental
exposures
promote
or
impede
healthy
aging.
Social
Vulnerability
Index
(SVI)
composite
index
accounting
for
different
facets
the
social,
economic,
demographic
environment
grouped
into
four
themes:
socioeconomic
status,
household
composition
disability,
minority
status
language,
housing
transportation.
We
aim
to
assess
concurrent
combined
associations
SVI
themes
on
PhenoAgeAccel
differential
effects
disadvantaged
groups.
use
electronic
health
records
data
31,913
patients
Mount
Sinai
Health
System
(116,952
person-years)
calculate
PhenoAge
years
with
available
laboratory
results
(2011–2022).
calculated
weighted
linear
combination
lab
results,
between
age.
A
decile
increase
mixture
dimensions
was
associated
0.23
(95%
CI
0.21,
0.25)
PhenoAgeAccel.
dimension
main
driver
association,
61%
weight.
Interaction
models
revealed
more
substantial
detrimental
association
women
racial
ethnic
minorities
differences
leading
themes.
These
findings
suggest
neighborhood-level
social
vulnerability
increases
its
residents,
increasing
risks.
Socioeconomic
has
larger
role
among
environment.
Aging Neuropsychology and Cognition,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 15
Published: Jan. 18, 2025
Greater
neighborhood
disadvantage
is
associated
with
poorer
global
cognition.
However,
less
known
about
the
variation
in
magnitude
of
effects
across
individual
cognitive
domains
and
whether
strength
these
associations
differs
by
individual-level
factors.
The
current
study
investigated
questions
a
community
sample
older
adults
(N
=
166,
mean
age
72.5
years,
51%
women),
who
reported
addresses,
linked
to
state-level
Area
Deprivation
Index
rankings,
completed
remote
validated
neuropsychological
tests
verbal
intelligence
(North
American
Adult
Reading
Test),
fluency
(Controlled
Oral
Word
Association
attention
(Digit
Span
Forward),
working
memory
Backward
Sequencing,
Letter-Number
Sequencing).
Linear
regressions
tested
between
each
test,
controlling
for
factors
(age,
sex,
education).
Exploratory
analyses
moderation
factor.
Independent
factors,
greater
was
lower
performance
domains:
(β
0.30,
p
<
.001),
-0.19,
.014),
.024),
two
three
-0.17-
-0.22,
ps
.004-.039).
Results
were
robust
correction
multiple
comparisons
spatial
autocorrelation.
In
addition,
higher
-
but
not
younger-older
(p
.035)
women
men
.001).
Education
did
moderate
associations.
Findings
suggest
that
living
more
disadvantaged
neighborhoods
exhibit
performance,
particularly
domain
intelligence.
Continued
investigation
effect
modification
may
be
fruitful
uncovering
whom
are
strongest.