Exposome analysis in toxicology: A comprehensive review DOI Creative Commons
Utsav Anand Mani,

Husain Abbas,

Mukesh Kumar

et al.

Deleted Journal, Journal Year: 2023, Volume and Issue: 1(1), P. 267 - 267

Published: Dec. 2, 2023

Toxicology has extensively evolved with the study of how external agents impact living organisms. This manuscript examines exposome, a paradigm representing all environmental exposures human encounter from conception onward, introducing holistic approach to understanding these effects on health. First coined by Dr. Christopher Wild in 2005, recent interpretations Miller and Jones emphasize not only factors but also behavioral influences, internal biochemical processes, implications microbiome. These augmentations underscore body’s dynamic responses continuous adjustments challenges. Traditional toxicology, which primarily focused singular compounds, often overlooked intricate interplays between multifaceted exposures; exposome aims bridge this gap. To analyze vast spectrum lifetime exposures, various state-of-the-art techniques are use, such as untargeted high-resolution mass spectrometry, biobanking, biomonitoring, diverse omics approaches (metabolomics, adductomics, proteomics, transcriptomics). methods empower scientists uncover unknown risks, offering insights into complex nexus health outcomes.

Language: Английский

Artificial intelligence in environmental health and public safety: A comprehensive review of USA strategies DOI Creative Commons

Adedayo Adefemi,

Emmanuel Adikwu Ukpoju,

Oladipo Olugbenga Adekoya

et al.

World Journal of Advanced Research and Reviews, Journal Year: 2023, Volume and Issue: 20(3), P. 1420 - 1434

Published: Dec. 24, 2023

This study explores the transformative role of artificial intelligence (AI) in environmental health and public safety within USA, focusing on pollution monitoring, emergency response, sustainable practices for public. With growing challenges posed by climate change, pollution, emerging threats, integration Artificial Intelligence strategies has become imperative. comprehensive review diverse array AI applications implemented United States to address issues enhance measures. The paper analyzes multifaceted across various domains, including air water quality disease surveillance, disaster infrastructure resilience. advancements technologies that have revolutionized data collection, analysis, prediction are examined. Machine learning algorithms, sensor networks, satellite imagery examined as tools real-time monitoring early detection hazards. Additionally, investigates surveillance systems, showcasing how predictive analytics data-driven models contribute identification containment infectious diseases. Furthermore, sheds light incorporation management, emphasizing modeling risk assessment optimizing response strategies. implementation smart city intelligent systems is discussed, highlighting contributes enhancing minimizing impact natural disasters. also critically evaluates ethical, legal, privacy considerations associated with widespread adoption initiatives. It addresses concerns related security, algorithmic biases, need transparent accountable governance frameworks. Through an in-depth analysis case studies, policies, initiatives, this provides insights into successes USA. concludes recommendations future research directions policy ensure responsible effective safeguarding safety. findings presented broader discourse leveraging resilient communities face evolving challenges.

Language: Английский

Citations

36

Spatial Dynamics and Social Order in Traditional Towns of Saudi Arabia’s Nadji Region: The Role of Neighborhood Clustering in Urban Morphology and Decision-Making Processes DOI Open Access
Mohammed Mashary Alnaim, Emad Noaime

Sustainability, Journal Year: 2024, Volume and Issue: 16(7), P. 2830 - 2830

Published: March 28, 2024

This study explores how the layout of neighborhoods in traditional settlements Saudi Arabia’s Najdi region influence social interactions and urban planning decisions. The uses a multidisciplinary approach that includes morphology, architectural phenomenology, sociological methods to investigate relationships between spatial organization decision-making processes on both macro micro levels decision-making. purpose is look at collective action affect fabric norms different levels. applies case analysis approaches settlements’ structure promotes peace among inhabitants while also sustaining cultural traditions. qualitative investigates arrangements behaviors, developing better understanding residents interact with their surroundings. According study’s findings, these layouts sustain customs assist communities adapting environmental changes by retaining activities. identifies significance balancing development retention important values implementation long-term conservation plans. Traditional towns can serve as design examples, emphasizing need acknowledge distinct value vernacular architecture modern fostering cohesion.

Language: Английский

Citations

7

Adopting Mechanistic Molecular Biology Approaches in Exposome Research for Causal Understanding DOI Creative Commons
Amy Foreman, Benedikt Warth, Ellen V.S. Hessel

et al.

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: 58(17), P. 7256 - 7269

Published: April 19, 2024

Through investigating the combined impact of environmental exposures experienced by an individual throughout their lifetime, exposome research provides opportunities to understand and mitigate negative health outcomes. While current is driven epidemiological studies that identify associations between effects, new frameworks integrating more substantial population-level metadata, including electronic administrative records, will shed further light on characterizing exposure risks. Molecular biology offers methods concepts study biological impacts exposomes in experimental computational systems. Of particular importance growing use omics readouts clinical studies. This paper calls for adoption mechanistic molecular approaches as essential step understanding genotype interactions underlying human phenotypes. A series recommendations are presented make necessary appropriate steps move from association causation, with a huge potential inform precision medicine population health. includes establishing hypothesis-driven laboratory testing within field, supported read across model systems human.

Language: Английский

Citations

6

Putting the exposome into practice: An analysis of the promises, methods and outcomes of the European human exposome network DOI Creative Commons
Yohan Fayet, Thomas Bonnin, Stefano Canali

et al.

Social Science & Medicine, Journal Year: 2024, Volume and Issue: 354, P. 117056 - 117056

Published: June 15, 2024

Contemporary research on the exposome, i.e. sum of all exposures an individual encounters throughout life and that may influence human health, bears promise integrative policy-relevant effect environment health. Critical analyses first generation exposome projects have voiced concerns over their actual breadth inclusion environmental factors a related risk molecularization public health issues. The emergence European Human Exposome Network (EHEN) provides opportunity to better situate ambitions priorities approach basis new ongoing research. We assess promises, methods, limitations EHEN, as case study second A critical textual analysis profile articles from each involved in published Environmental Epidemiology, was carried out derive common priorities, innovations, methodological conceptual choices across EHEN discuss it. consolidates its outlook by reinforcing volume variety data, data infrastructure diversifying strategies deliver actionable knowledge. Yet data-driven severely restrict geographical political scope this knowledge issues primarily urban setups, which aggravate some socio-spatial inequalities Europe. doubles down initial ambition effects fuel interventions. This intensification is, however, accompanied significant epistemological challenges doesn't help overcome severe restrictions thus advocate for increased reflexivity conceptually methodologically

Language: Английский

Citations

6

Protective effect of restorative possibilities on cognitive function and mental health in children and adolescents: A scoping review including the role of physical activity DOI Creative Commons
Angel M. Dzhambov, Peter Lercher, Natalia Vincens

et al.

Environmental Research, Journal Year: 2023, Volume and Issue: 233, P. 116452 - 116452

Published: June 18, 2023

Background The exposome approach can be a powerful tool for understanding the intertwining of social, physical, and internal influences that shape mental health cognitive development throughout childhood. To distil conceptual models subsequent analyses, EU-funded project Early Environmental quality Life-course effects (Equal-Life) has conducted literature reviews on potential mediators linking to these outcomes. We report scoping review model role restorative possibilities physical activity. Methods Peer-reviewed studies published since year 2000 in English, association between health/cognition children/adolescents, quantitatively investigating restoration/restorative as mediating variable were considered. Database searches last updated December 2022. used an unstructured expert-driven fill gaps reviewed literature. Results Five records three distinct identified, indicating scarcity empirical evidence this newly developing research area. Not only few numbers, but also cross-sectional, lending tentative support idea perceived adolescent's living environment might mediate greenspace health. Physical activity emerged mediator leading better psychological outcomes environments. provide critical discussion caveats when restoration mechanism children propose hierarchical including restoration, activity, relational dynamics their environment, social context, well environments other than nature. Conclusions It is justified further explore early-life health/cognitive development. important consider child perspective specific methodological caveats. Given evolving definitions/operationalizations, Equal-Life will attempt gap

Language: Английский

Citations

16

Association between trajectories of the neighborhood social exposome and mental health in late adolescence: A FinnTwin12 cohort study DOI Creative Commons
Zhiyang Wang, Gabin Drouard, Alyce M. Whipp

et al.

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 358, P. 70 - 78

Published: April 30, 2024

Adolescent mental health problems impose a significant burden. Exploring evolving social environments could enhance comprehension of their impact on health. We aimed to depict the trajectories neighborhood exposome from middle late adolescence and assess intricate relationship between them adolescent Participants (n = 3965) FinnTwin12 cohort with completed questionnaires at age 17were used. Nine measures were assessed. The comprised 28 indicators. Trajectories these indicators ages 12 17 summarized via latent growth curve modeling into factors, including baseline intercept. Mixture effects all factors assessed through quantile-based g-computation. Repeated generalized linear regression identified factors. Sex stratification was performed. linear-quadratic model most optimal trajectory model. No mixture effect detected. Regression models showed some saliently linked p-factor, internalizing problems, anxiety, hyperactivity, aggression. majority intercepts. Quadratic about mother tongues correlated anxiety among sex-combined participants males. factor in proportion households couples without children associated females. limited only neighborhood-level exposures, multilevel contextual situation interfered our assessment. modestly influenced Tackling root causes inequalities targeted programs for living conditions improve

Language: Английский

Citations

4

New Directions in Geroscience: Integrating Social and Behavioral Drivers of Biological Aging DOI

Lisbeth Nielsen,

Anna L. Marsland, Elissa J. Hamlat

et al.

Psychosomatic Medicine, Journal Year: 2024, Volume and Issue: 86(5), P. 360 - 365

Published: May 8, 2024

ABSTRACT The “geroscience hypothesis” posits that slowing the physiological processes of aging would lead to delayed disease onset and longer healthspan lifespan. This shift from a focus on solely treating existing process is toward prevention, including risk factors found in social environment. Although geroscience traditionally has focused molecular cellular drivers biological aging, more fundamental causes may be exposome—the complex array human environmental exposures shape health disease. exposome interact with accelerate biology. In this commentary, we review potential these insights emerging field translational geroscience. articles special issue highlight how stress determinants are associated biomarkers such as inflammation, epigenetic clocks, telomeres, spotlight promising interventions mitigate stress-related inflammation. For incorporate into its agenda, studies needed elucidate quantify effects consider intervention targets. life course perspective allows us measure both biology over time sensitive periods development major transitions. addition, given rapid changes measurement biology, which include machine learning techniques, multisystem phenotypes being developed better reflect whole body replacing reliance single system biomarkers. expanded integrated geroscience, strategies targeting hold promise for achieving equity extending healthy longevity.

Language: Английский

Citations

4

Social Vulnerability and Biological Aging in New York City: An Electronic Health Records-Based Study DOI Creative Commons
Pablo Knobel, Elena Colicino, Itai Kloog

et al.

Journal of Urban Health, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

Abstract Chronological age is not an accurate predictor of morbidity and mortality risk, as individuals’ aging processes are diverse. Phenotypic acceleration (PhenoAgeAccel) a validated biological measure incorporating chronological biomarkers from blood samples commonly used in clinical practice that can better reflect aging-related risk. The heterogeneity age-related decline random, environmental exposures promote or impede healthy aging. Social Vulnerability Index (SVI) composite index accounting for different facets the social, economic, demographic environment grouped into four themes: socioeconomic status, household composition disability, minority status language, housing transportation. We aim to assess concurrent combined associations SVI themes on PhenoAgeAccel differential effects disadvantaged groups. use electronic health records data 31,913 patients Mount Sinai Health System (116,952 person-years) calculate PhenoAge years with available laboratory results (2011–2022). calculated weighted linear combination lab results, between age. A decile increase mixture dimensions was associated 0.23 (95% CI 0.21, 0.25) PhenoAgeAccel. dimension main driver association, 61% weight. Interaction models revealed more substantial detrimental association women racial ethnic minorities differences leading themes. These findings suggest neighborhood-level social vulnerability increases its residents, increasing risks. Socioeconomic has larger role among environment.

Language: Английский

Citations

0

Neighborhood-level socioeconomic disadvantage is associated with multiple cognitive domains in a community sample of older adults DOI
Rebecca G. Reed, Abby R. Hillmann

Aging Neuropsychology and Cognition, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 15

Published: Jan. 18, 2025

Greater neighborhood disadvantage is associated with poorer global cognition. However, less known about the variation in magnitude of effects across individual cognitive domains and whether strength these associations differs by individual-level factors. The current study investigated questions a community sample older adults (N = 166, mean age 72.5 years, 51% women), who reported addresses, linked to state-level Area Deprivation Index rankings, completed remote validated neuropsychological tests verbal intelligence (North American Adult Reading Test), fluency (Controlled Oral Word Association attention (Digit Span Forward), working memory Backward Sequencing, Letter-Number Sequencing). Linear regressions tested between each test, controlling for factors (age, sex, education). Exploratory analyses moderation factor. Independent factors, greater was lower performance domains: (β 0.30, p < .001), -0.19, .014), .024), two three -0.17- -0.22, ps .004-.039). Results were robust correction multiple comparisons spatial autocorrelation. In addition, higher - but not younger-older (p .035) women men .001). Education did moderate associations. Findings suggest that living more disadvantaged neighborhoods exhibit performance, particularly domain intelligence. Continued investigation effect modification may be fruitful uncovering whom are strongest.

Language: Английский

Citations

0

Identification of exposome clusters based on societal, social, built and natural environment – results of the ABCD cohort study DOI Creative Commons
Klaus Telkmann, Helene Gudi-Mindermann,

Rik Bogers

et al.

Environment International, Journal Year: 2025, Volume and Issue: unknown, P. 109335 - 109335

Published: Feb. 1, 2025

Language: Английский

Citations

0