Exposome analysis in toxicology: A comprehensive review DOI Creative Commons
Utsav Anand Mani,

Husain Abbas,

Mukesh Kumar

et al.

Deleted Journal, Journal Year: 2023, Volume and Issue: 1(1), P. 267 - 267

Published: Dec. 2, 2023

Toxicology has extensively evolved with the study of how external agents impact living organisms. This manuscript examines exposome, a paradigm representing all environmental exposures human encounter from conception onward, introducing holistic approach to understanding these effects on health. First coined by Dr. Christopher Wild in 2005, recent interpretations Miller and Jones emphasize not only factors but also behavioral influences, internal biochemical processes, implications microbiome. These augmentations underscore body’s dynamic responses continuous adjustments challenges. Traditional toxicology, which primarily focused singular compounds, often overlooked intricate interplays between multifaceted exposures; exposome aims bridge this gap. To analyze vast spectrum lifetime exposures, various state-of-the-art techniques are use, such as untargeted high-resolution mass spectrometry, biobanking, biomonitoring, diverse omics approaches (metabolomics, adductomics, proteomics, transcriptomics). methods empower scientists uncover unknown risks, offering insights into complex nexus health outcomes.

Language: Английский

Geospatial Science for the Environmental Epidemiology of Cancer in the Exposome Era DOI Creative Commons
Trang VoPham, Alexandra J. White, Rena R. Jones

et al.

Cancer Epidemiology Biomarkers & Prevention, Journal Year: 2024, Volume and Issue: 33(4), P. 451 - 460

Published: April 3, 2024

Abstract Geospatial science is the of location or place that harnesses geospatial tools, such as geographic information systems (GIS), to understand features environment according their locations. has been transformative for cancer epidemiologic studies through enabling large-scale environmental exposure assessments. As research paradigm exposome, totality exposures across life course, continues evolve, will serve a critical role in determining optimal practices how measure part external exposome. The objectives this article are provide summary key concepts, present conceptual framework illustrates applied epidemiology practice and lens discuss following opportunities advancing research: enhancing spatial temporal resolutions extents data; methodologies climate change factors; approaches facilitating use patient addresses studies; combining internal exposome data models insights into biological pathways environment–disease relationships; incorporation personalized screening policies clinical decision making.

Language: Английский

Citations

1

Unveiling organizational consciousness: a conceptual framework for nurturing thriving organizations DOI
Muhammad Ajmal, Azmat Islam,

Zeenat Islam

et al.

Journal of Organizational Change Management, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 3, 2024

Purpose This article aims to tackle the organization's problems with a new paradigm of organizational consciousness by developing framework. Design/methodology/approach The Phenomenological and Framework Synthesis approach is used develop conceptual framework for consciousness. Findings research highlights consciousness's implications long-term sustainable success. It emphasizes positive impact conscious organizations on stakeholder well-being resolution environmental social problems. Originality/value encompasses collective awareness, values, purpose that guide an actions decisions. aligning needs, goals all stakeholders' social, environmental, well-being. interconnectedness stakeholders encourages system-thinking perspective. Furthermore, it acknowledges role individual group in driving transformation. discusses pathway success through practices, emphasizing value creation beyond monetary gain. explores leadership, innovative continuous learning, adaptation fostering organizations.

Language: Английский

Citations

1

Environmental perceptions, self-regulation, and coping with noise mediate the associations between children’s physical environment and sleep and mental health problems DOI Creative Commons
Peter Lercher, Angel M. Dzhambov, Kerstin Persson Waye

et al.

Environmental Research, Journal Year: 2024, Volume and Issue: unknown, P. 120414 - 120414

Published: Nov. 1, 2024

Language: Английский

Citations

1

Children’s access to urban greenspace: a survey of factors and measures DOI Creative Commons
Roos Teeuwen, Alessandro Bozzon, Achilleas Psyllidis

et al.

Cities & Health, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 21

Published: Sept. 2, 2024

Access to greenspace impacts children's physical, social, and mental health. Numerous factors affect access urban greenspaces, often distinct from those affecting the general population, including parental restrictions, limited routine activity-space, particular preferences. Most accessibility measures, however, employ same principles for children a comprehensive exploration of corresponding measures remains lacking. We conduct scoping review workshops with researchers practitioners identify greenspace, synthesize them into conceptual model, assess how existing address these factors. focus on aged 6–11 years old. Our analysis indicates involves trade-off between reachability, determined by route connecting child's starting setting attractiveness, greenspaces adhere child's, their companions', preferences motivations visiting. Safety perceptions are important throughout. Existing predominantly emphasize neglecting personal characteristics motivations. Based our findings, we propose future directions developing child-centered metrics. overview metrics can facilitate decision-making in selection suitable while model foster shared understanding greenspace.

Language: Английский

Citations

1

Exposome analysis in toxicology: A comprehensive review DOI Creative Commons
Utsav Anand Mani,

Husain Abbas,

Mukesh Kumar

et al.

Deleted Journal, Journal Year: 2023, Volume and Issue: 1(1), P. 267 - 267

Published: Dec. 2, 2023

Toxicology has extensively evolved with the study of how external agents impact living organisms. This manuscript examines exposome, a paradigm representing all environmental exposures human encounter from conception onward, introducing holistic approach to understanding these effects on health. First coined by Dr. Christopher Wild in 2005, recent interpretations Miller and Jones emphasize not only factors but also behavioral influences, internal biochemical processes, implications microbiome. These augmentations underscore body’s dynamic responses continuous adjustments challenges. Traditional toxicology, which primarily focused singular compounds, often overlooked intricate interplays between multifaceted exposures; exposome aims bridge this gap. To analyze vast spectrum lifetime exposures, various state-of-the-art techniques are use, such as untargeted high-resolution mass spectrometry, biobanking, biomonitoring, diverse omics approaches (metabolomics, adductomics, proteomics, transcriptomics). methods empower scientists uncover unknown risks, offering insights into complex nexus health outcomes.

Language: Английский

Citations

2