Ecotoxicology and Environmental Safety,
Journal Year:
2024,
Volume and Issue:
283, P. 116863 - 116863
Published: Aug. 10, 2024
Cadmium
(Cd)
is
a
toxic
heavy
metal
pollutant
in
the
environment.
Excessive
Cd
water
has
effects
on
fish,
endangering
their
healthy
growth
and
ultimately
affecting
quality
safety
of
aquatic
products.
To
evaluate
toxicity
excessive
to
fish
through
potential
oxidative
damage,
Siniperca
chuatsi
was
exposed
for
15
days.
It
found
that
exposure
significantly
decreased
survival
rate
S.
detected
muscle.
Meanwhile,
disrupts
redox
balance
by
reducing
antioxidant
enzyme
activities,
increasing
reactive
oxygen
species
(ROS)
malondialdehyde
(MDA)
levels
muscle,
promoting
damage.
Histomorphology
showed
enlargement
muscle
fiber
gaps,
cell
swelling
vacuolar
degeneration
after
exposure.
In
addition,
induced
up-regulating
expression
miR-216a,
while
down-regulation
Nrf2
protein
its
downstream
genes
expression.
Further
analysis
revealed
miR-216a
negatively
correlated
with
Nrf2,
injection
antagomir
enhanced
genes,
as
well
activity
enzymes,
thereby
damage
fish.
These
results
suggested
miR-216a-mediated
signaling
pathway
plays
an
important
role
Cd-induced
stress
Animals,
Journal Year:
2024,
Volume and Issue:
14(16), P. 2318 - 2318
Published: Aug. 9, 2024
Marine
mollusks,
including
oysters,
are
highly
tolerant
to
high
levels
of
cadmium
(Cd),
but
the
molecular
mechanisms
underlying
their
response
acute
Cd
exposure
remain
unclear.
In
this
study,
Pacific
oyster
Crassostrea
gigas
was
used
as
a
biological
model,
exposed
stress
for
96
h.
Transcriptomic
analyses
gills
were
performed,
and
metabolomic
further
validated
these
results.
our
total
111
differentially
expressed
metabolites
(DEMs)
2108
genes
(DEGs)
identified
under
exposure.
Further
revealed
alterations
in
key
metabolic
pathways
associated
with
heavy
metal
response.
triggered
physiological
responses
enhanced
oxidative
disturbances
energy
metabolism,
changes
oysters
stress.
Moreover,
could
effectively
enhance
tolerance
detoxification
ability
through
activating
ABC
transporters,
enhancing
glutathione
metabolism
sulfur
relay
system
gill
cells,
regulating
metabolism.
This
study
reveals
mechanism
explores
by
using
combined
metabolomics
transcriptome
analysis.
Environmental Sciences Europe,
Journal Year:
2025,
Volume and Issue:
37(1)
Published: Jan. 15, 2025
Abstract
The
aquaculture
sector
is
facing
environmental
issues
because
of
rising
chemical
pollution
aquatic
systems,
which
may
be
caused
by
man-made
or
natural
causes.
combined
action
these
mixtures
can
produce
an
effect
that
either
severalfold
higher
lower
than
the
overall
toxicity
individual
components.
objective
this
study
to
evaluate
impact
three
toxicants:
lead
(Pb
0.088
mg
L
−1
),
mercury
(Hg
0.084
and
pendimethalin
(PM
0.355
)
their
combinations
on
behavior,
oxidative
stress,
immunology,
biochemistry,
histopathological
changes
in
Nile
tilapia.
results
show
mortality
was
evident
across
all
treatment
groups
highest
mixture
(MIX)
group,
at
33.4%.
Some
behavioral
included
increased
mucus
secretion,
fin
rot,
dark
skin
coloration
fish,
were
evidently
exacerbated
MIX
group.
erythrocyte
hemoglobin
indices
presented
marked
reductions
PM
comparison
control
group
had
levels
serum
creatinine
urea,
as
well
liver
enzymes
alanine
aminotransferase,
aspartate
transaminase,
alkaline
phosphatase.
They
also
malondialdehyde
total
antioxidant
capacity,
showed
stress.
stress
biomarkers,
cortisol
glucose,
greater
groups.
neurobehavioral
assessment
demonstrated
noticeable
decreased
acetylcholinesterase
MIX-exposed
In
immunological
parameters,
nitric
oxide
lysozyme
lower,
especially
experimental
groups,
spleen
pro-inflammatory
cytokine
genes
higher.
examination
revealed
lesions
gills,
liver,
brains
form
inflammation,
necrosis,
circulatory
alterations.
Among
exposed
exhibited
changes.
Collectively,
our
findings
significant
toxic
effects
heavy
metals
herbicides
tilapia,
revealing
a
synergistic
both
physiological
responses
resulting
from
exposures.
data
indicate
ecological
hazards
associated
with
ecosystems.
