Frontiers in Toxicology,
Journal Year:
2024,
Volume and Issue:
6
Published: Sept. 18, 2024
Glyphosate
is
a
chemical
compound
derived
from
glycine,
marketed
as
broad-spectrum
herbicide,
and
represents
one
of
the
most
widely
used
pesticides
in
world.
For
long
time,
it
was
assumed
that
glyphosate
harmless,
either
due
to
its
selective
enzymatic
acting
method
on
plants,
because
commercial
formulations
were
believed
contain
only
inert
chemicals.
spread
environment,
general
population
daily
exposed
via
different
routes,
including
consumption
both
plant,
non-plant
based
foods.
has
been
detected
high
amounts
workers’
urine,
but
likewise
bodily
fluids,
such
blood
maternal
milk,
also
60%–80%
population,
children.
Considering
massive
presence,
exposure
could
be
considered
health
risk
for
humans.
Indeed,
2015,
IARC
(International
Agency
Research
Cancer)
classified
derivatives
Group
2A,
probable
human
carcinogens.
In
2022,
nevertheless,
EFSA
(European
Food
Safety
Authority)
stated
available
data
did
not
provide
sufficient
evidence
prove
mutagenic/carcinogenic
effects
glyphosate.
Therefore,
European
Commission
(EC)
decided
renew
approval
another
10
years.
The
purpose
this
review
examine
scientific
literature,
focusing
potential
risks
arising
glyphosate,
metabolites
products
(e.g.,
Roundup
®
),
with
particular
regard
mutagenic
carcinogenic
endocrine
disrupter
(ED)
especially
reproductive
system.
Processes,
Journal Year:
2025,
Volume and Issue:
13(3), P. 860 - 860
Published: March 14, 2025
Glyphosate
(GLY)
is
the
most
widely
used
herbicide
in
agriculture
worldwide,
posing
a
significant
contamination
risk
to
rivers,
lakes,
wetlands,
and
soils.
Its
ultimate
fate
represents
potential
threat
health
of
both
terrestrial
aquatic
ecosystems.
This
study
evaluated
removal
efficiency
glyphosate
conventional
pollutants
mesocosm-scale
horizontal
subsurface
flow-constructed
wetlands
planted
with
Canna
indica,
Heliconia
psittacorum,
Alpinia
purpurata
runoff
water
contaminated
glyphosate.
Additionally,
examined
performances
these
species
monoculture
polyculture
settings
tropical
ornamental
plants.
indica
exhibited
highest
growth
(up
160
cm)
conditions,
as
well
efficiencies
for
total
nitrogen
(TN),
phosphorus
(TP),
phosphate
(PO43⁻),
achieving
91%,
93%,
98%
removal,
respectively.
Polyculture
systems
demonstrated
superior
ammonium
efficiency,
reaching
94%.
(>5
ppm
after
40
days)
psittacorum
200
were
effective
removal.
can
be
effectively
removed
from
environments
through
constructed
species,
offering
sustainable
approach
mitigating
bodies.
Toxicology Reports,
Journal Year:
2025,
Volume and Issue:
unknown, P. 102018 - 102018
Published: March 1, 2025
New
psychoactive
substances
(NPS)
have
emerged
as
a
significant
public
health
concern,
with
synthetic
cannabinoid
receptor
agonists
(SCRAs)
and
ketamine
derivatives
being
among
the
most
frequently
detected
compounds
in
forensic
context
worldwide.
The
Fish
Embryo
Acute
Toxicity
(FET)
Maximum
Tolerated
Concentration
(MTC)
tests
are
used
to
evaluate
acute
toxicity
of
chemicals.
In
this
study,
we
these
assays
three
NPS
zebrafish
embryos
larvae:
SCRA
MDMB-4en-PINACA
deschloroketamine
(DCK)
2-fluorodeschloroketamine
(2F-DCK).
Our
findings
demonstrated
that
induced
severe
developmental
abnormalities,
including
pericardial
edema
yolk
edema,
along
high
embryo
mortality
(10
µM),
characterized
by
endpoints
such
coagulation,
lack
heartbeat,
somite
formation.
contrast,
DCK
2F-DCK
exhibited
low
even
at
higher
concentrations.
larval
stages,
presented
8
%
larvae
µM)
eight
days
post-fertilization
(dpf),
whereas
led
100
2000
µM
MTC
test
dpf.
LC50
was
calculated
for
FET
MDMB-4en-PINACA,
both
2F-DCK.
Additionally,
our
results
support
absence
N-methyl-D-aspartate
(NMDA)
receptors
early
life
stages
described
previous
studies
highlight
significance
intoxications
when
NMDA
is
expressed.
Notably,
significantly
toxicity,
an
approximately
26
times
lower
than
derivatives.
These
particularly
relevant
given
increasing
global
prevalence
NPS-related
fatalities.
Using
vivo
model
toxicological
research
provides
efficient
approach
screening
effects
emerging
NPS.
