Journal of Environmental Sciences,
Journal Year:
2024,
Volume and Issue:
155, P. 316 - 328
Published: Aug. 24, 2024
This
study
aimed
to
identify
the
worst
"bad
actors"
in
mixtures
of
pollutants
contributing
liver
damage
and
shorter
telomeres
U.S.
population,
using
Weighted
Quantile
Sum
(WQS)
modeling
with
stratification
by
race/ethnicity.
We
conducted
a
comprehensive
cross-sectional
analysis
National
Health
Nutrition
Examination
Survey
datasets:
a)
33,979
adults
blood
levels
cadmium
(Cd),
lead
(Pb),
mercury,
including
subsets
measurements
per-/polyfluoroalkyl
substances
(PFAS),
polychlorinated
biphenyls
(PCBs)/polychlorinated
dibenzo-p-dioxins
dibenzofurans
(PCDD/Fs);
b)
7360
telomeres,
Cd,
Pb.
Multivariable-adjusted
WQS
regression
examined
associations
between
mixture
indices
injury
[alanine
aminotransferase
(ALT)-elevation],
advanced
liver-fibrosis
(LF),
telomere
length.
WQSmetal
were
associated
advanced-LF
all
racial/ethnic
groups.
The
top
contributor
was
Cd
total
population
non-Hispanic
Whites
(NHW),
while
Pb
Blacks
(NHB).
WQSmetal-PCB-PCDD/F
index
ALT-elevation,
PCB126,
as
main
contributors;
odds
ratio
(OR)
per
decile
1.50
(95
%CI,
1.26–1.78),
OR
WQSmetal-PFAS
1.03
0.98–1.05),
not
significant.
telomeres.
NHW,
major
bad
actor
NHB,
suggesting
that
NHB
may
be
especially
susceptible
toxicity.
Metals
Metal
PCB/PCDD/F
ALT-elevation.
Heavy
metals
organic
chemicals
contribute
liver-related
morbidity
healthcare
disparities.
Seminars in Liver Disease,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 21, 2025
Environmental
pollutants
significantly
impact
liver
disease
development,
progression,
and
outcomes.
This
review
examines
the
complex
relationship
between
environmental
exposures
pathology,
from
malignant
conditions
like
hepatocellular
carcinoma
to
steatotic
cholestatic
diseases.
Key
factors
include
air
pollutants,
volatile
organic
compounds,
persistent
heavy
metals,
per-
polyfluoroalkyl
substances.
These
compounds
can
act
through
multiple
mechanisms,
including
endocrine
disruption,
metabolic
perturbation,
oxidative
stress,
direct
hepatotoxicity.
The
of
these
is
often
modified
by
such
as
sex,
diet,
genetic
predisposition.
Recent
research
has
revealed
that
even
low-level
certain
chemicals
affect
health,
particularly
when
combined
with
other
risk
factors.
emergence
exposomics
a
tool
promises
enhance
our
understanding
how
influence
disease.
Importantly,
exposure
effects
vary
demographic
socioeconomic
factors,
highlighting
justice
concerns.
Implementation
this
knowledge
in
clinical
practice
requires
new
diagnostic
approaches,
healthcare
system
adaptations,
increased
awareness
among
medical
professionals.
In
conclusion,
provides
comprehensive
examination
current
evidence
linking
discusses
implications
for
public
health
policy.
Frontiers in Public Health,
Journal Year:
2025,
Volume and Issue:
13
Published: April 4, 2025
Background
Cadmium
(Cd)
accumulates
in
the
body
over
time,
damaging
organs
such
as
liver,
kidneys,
and
brain.
Some
researchers
have
suggested
that
elevated
blood
Cd
levels
may
contribute
to
onset
progression
of
nonalcoholic
fatty
liver
disease
(NAFLD).
However,
only
a
few
studies
explored
relationship
between
exposure
long-term
health
outcomes
patients
with
NAFLD.
This
study
aimed
evaluate
predictive
value
cadmium
for
mortality
risk
Methods
analyzed
data
from
13,450
NAFLD
National
Health
Nutrition
Examination
Survey
(NHANES)
database,
covering
years
1999
2018.
Patients
were
categorized
into
three
groups
based
on
their
levels.
The
concentrations
all-cause,
cardiovascular,
cancer
was
assessed
using
Cox
proportional
hazards
regression
while
accounting
potential
confounders.
Results
visualized
Kaplan–Meier
restricted
cubic
spline
(RCS)
curves.
Stratified
analyses
performed
validation
robustness
results.
After
adjusting
all
covariates,
positively
associated
NAFLD,
showing
significant
linear
dose–response
relationship.
Specifically,
each
unit
increase
Log-transformed
concentration,
all-cause
increased
by
191%
(HR
=
2.91,
95%
CI:
2.39–3.53);
cardiovascular
160%
2.6,
1.80–3.76);
279%
3.79,
2.54–5.65).
analysis
confirmed
these
findings.
Conclusion
Our
suggests
high
Blood
adversely
affect
prognosis
Individuals
should
be
aware
take
preventive
measures.
Moreover,
stricter
environmental
protection
policies
necessary
reduce
exposure.
Toxicology,
Journal Year:
2025,
Volume and Issue:
unknown, P. 154163 - 154163
Published: April 1, 2025
Lead
(Pb)
has
been
used
by
humans
since
prehistoric
times
to
make
tools
due
its
malleability
and
durability.
The
Roman
Empire,
the
Industrial
Revolution,
introduction
of
Pb
in
gasoline
during
1920s
contributed
increased
environmental
concentrations.
toxicity
led
removal
from
after
several
decades.
However,
continues
be
emitted
various
anthropogenic
sources,
including
but
not
limited
batteries,
mining,
foundries,
smelting,
e-waste
recycling,
painting.
remains
an
concern,
as
no
established
safe
concentration
for
human
health
identified.
Children
are
more
susceptible
absorption
poisoning
Pb.
Occupational
exposure
poses
a
significant
risk
workers
individuals
living
near
lead
industries.
primary
routes
inhalation
ingestion,
bioaccumulation
biomagnification
through
food
chain
major
sources
exposure.
This
review
aims
provide
overview
systemic
Pb,
effects
on
lungs,
blood,
liver,
kidneys,
nervous,
cardiovascular,
reproductive
systems.
Since
is
classified
probable
carcinogen
humans,
article
also
addresses
genotoxicity
cancer
risk.
Furthermore,
it
reviews
most
researched
mechanisms
toxicity,
calcium
mimicry,
oxidative
stress,
inflammation,
along
with
other
less-studied
mechanisms.
Nevertheless,
authors
emphasize
importance
exploring
less
examined
cells,
tissues,
deepen
understanding
at
concentrations,
particularly
cases
chronic
low-level
exposure,
develop
better
prevention
treatment
strategies
poisoning.
Digestive and Liver Disease,
Journal Year:
2023,
Volume and Issue:
56(4), P. 571 - 578
Published: Dec. 26, 2023
Metabolic
dysfunction-associated
steatotic
liver
disease
(MASLD)
has
been
traditionally
associated
with
insulin
resistance
and
obesity.
Recently,
pollutants
have
shown
to
contribute
the
development
of
MASLD.
Given
global
burden
MASLD,
understanding
whether
are
merely
steatosis
or
its
progression
advanced
chronic
(ACLD)
hepatocellular
carcinoma
(HCC)
is
critical.
Workers
exposed
occupational
toxicants
represent
an
ideal
population
for
assessing
potentially
hazardous
consequences
professional
exposure.
Confirming
a
link
between
exposure
ACLD/HCC
may
not
only
provide
further
elements
in
but
also
preventive
strategies
workers.
