Mixture analysis of associations between environmental and workplace toxins and liver damage and telomere length, stratified by race/ethnicity DOI Creative Commons
Ning Ma, Rowena Yip, Mark Woodward

et al.

Journal of Environmental Sciences, Journal Year: 2024, Volume and Issue: 155, P. 316 - 328

Published: Aug. 24, 2024

This study aimed to identify the worst "bad actors" in mixtures of pollutants contributing liver damage and shorter telomeres U.S. population, using Weighted Quantile Sum (WQS) modeling with stratification by race/ethnicity. We conducted a comprehensive cross-sectional analysis National Health Nutrition Examination Survey datasets: a) 33,979 adults blood levels cadmium (Cd), lead (Pb), mercury, including subsets measurements per-/polyfluoroalkyl substances (PFAS), polychlorinated biphenyls (PCBs)/polychlorinated dibenzo-p-dioxins dibenzofurans (PCDD/Fs); b) 7360 telomeres, Cd, Pb. Multivariable-adjusted WQS regression examined associations between mixture indices injury [alanine aminotransferase (ALT)-elevation], advanced liver-fibrosis (LF), telomere length. WQSmetal were associated advanced-LF all racial/ethnic groups. The top contributor was Cd total population non-Hispanic Whites (NHW), while Pb Blacks (NHB). WQSmetal-PCB-PCDD/F index ALT-elevation, PCB126, as main contributors; odds ratio (OR) per decile 1.50 (95 %CI, 1.26–1.78), OR WQSmetal-PFAS 1.03 0.98–1.05), not significant. telomeres. NHW, major bad actor NHB, suggesting that NHB may be especially susceptible toxicity. Metals Metal PCB/PCDD/F ALT-elevation. Heavy metals organic chemicals contribute liver-related morbidity healthcare disparities.

Language: Английский

The mechanism of DEHP-induced lipid accumulation in liver of female zebrafish DOI

Y. Mi,

Jiamin Shi,

Xuan Ma

et al.

Environmental Pollution, Journal Year: 2024, Volume and Issue: unknown, P. 125455 - 125455

Published: Dec. 1, 2024

Language: Английский

Citations

1
Unraveling the mechanisms underlying diabetic cataracts: insights from Mendelian randomization analysis DOI Creative Commons
Wenlan Liu,

Yiming Pan

Redox Report, Journal Year: 2024, Volume and Issue: 29(1)

Published: Dec. 5, 2024

Background Diabetic cataract (DC) is a major cause of blindness, with its pathogenesis involving oxidative stress and ferroptosis, according to recent studies.

Language: Английский

Citations

1
Investigation of the relationship between lead exposure in heavy metals mixtures and the prevalence of stroke: a cross-sectional study DOI Creative Commons
Jiarong He, Wei Zhang, Fang Zhao

et al.

BMC Public Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: Dec. 18, 2024

The adverse effects of environmental toxic metal exposure on human health are well-documented. However, the specific influence heavy stroke prevalence remains underexplored. This study utilized data from National Health and Nutrition Examination Survey (NHANES) spanning 2011 to 2018 investigate association between blood concentrations incidence stroke. Four analytical approaches—logistic regression, Restricted Cubic Splines (RCS), Weighted Quantile Sum regression (WQS), Bayesian Kernel Machine Regression (BKMR)—were employed assess relationship, with a mediation analysis conducted explore role inflammatory markers in Pb exposure-induced Among 9,399 participants this project, 421 (4.4%) were diagnosed After adjusting for covariates, multivariable logistic model identified positive logarithmic concentration Besides, using both WQS BKMR methodologies found consistent composite metals frequency cases, emerging as predominant factor relationship. An evident saturation phenomenon was noted correlation lead risk Additionally, interplay manifestation be partially mediated by markers, which responsible 6.9% observed effect (95%CI:0.01, 0.24, P = 0.03). These findings indicate notable contribution risk, highlighting inflammation significant intermediary mechanism exposure-stroke association.

Language: Английский

Citations

1
Association of blood cadmium levels with all-cause and cause-specific mortality among adults with Non-Alcoholic Fatty Liver Disease: A prospective cohort study DOI Creative Commons

Congxi Xu,

Zhi Li, Shirui Hao

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: June 26, 2024

Abstract Background Cadmium (Cd) accumulates in the body over time, damaging organs such as liver, kidneys, and brain. Some researchers have suggested that elevated blood Cd levels may contribute to onset progression of nonalcoholic fatty liver disease (NAFLD). However, only a few studies investigated association between exposure long-term health outcomes patients with NAFLD. This study aimed evaluate predictive value cadmium for mortality risk Methods analyzed data from 13,790 NAFLD National Health Nutrition Examination Survey (NHANES) database, covering years 1999 2018. Patients were categorized into three groups based on their levels. The relationship concentrations all-cause, cardiovascular, cancer was assessed using Cox proportional hazards regression while accounting potential confounders. Results visualised Kaplan-Meier restricted cubic spline (RCS) curves. Stratified analyses performed validation robustness results. included individuals. After adjusting all covariates, positively associated NAFLD, showing significant linear dose-response relationship. Specifically, each unit increase Log-transformed concentration, all-cause increased by 195% (HR = 2.95, 95% CI: 2.43–3.58); cardiovascular 173% 2.73, 1.90–3.93); 277% 3.77, 2.54–5.59). analysis confirmed these findings, indicating female those under 60 more susceptible effects mortality. Additionally, hypertension age vulnerable Conclusions Our suggests high Blood adversely affect prognosis Individuals should be aware take preventive measures. Moreover, stricter environmental protection policies necessary reduce exposure.

Language: Английский

Citations

0
Mixture analysis of associations between environmental and workplace toxins and liver damage and telomere length, stratified by race/ethnicity DOI Creative Commons
Ning Ma, Rowena Yip, Mark Woodward

et al.

Journal of Environmental Sciences, Journal Year: 2024, Volume and Issue: 155, P. 316 - 328

Published: Aug. 24, 2024

This study aimed to identify the worst "bad actors" in mixtures of pollutants contributing liver damage and shorter telomeres U.S. population, using Weighted Quantile Sum (WQS) modeling with stratification by race/ethnicity. We conducted a comprehensive cross-sectional analysis National Health Nutrition Examination Survey datasets: a) 33,979 adults blood levels cadmium (Cd), lead (Pb), mercury, including subsets measurements per-/polyfluoroalkyl substances (PFAS), polychlorinated biphenyls (PCBs)/polychlorinated dibenzo-p-dioxins dibenzofurans (PCDD/Fs); b) 7360 telomeres, Cd, Pb. Multivariable-adjusted WQS regression examined associations between mixture indices injury [alanine aminotransferase (ALT)-elevation], advanced liver-fibrosis (LF), telomere length. WQSmetal were associated advanced-LF all racial/ethnic groups. The top contributor was Cd total population non-Hispanic Whites (NHW), while Pb Blacks (NHB). WQSmetal-PCB-PCDD/F index ALT-elevation, PCB126, as main contributors; odds ratio (OR) per decile 1.50 (95 %CI, 1.26–1.78), OR WQSmetal-PFAS 1.03 0.98–1.05), not significant. telomeres. NHW, major bad actor NHB, suggesting that NHB may be especially susceptible toxicity. Metals Metal PCB/PCDD/F ALT-elevation. Heavy metals organic chemicals contribute liver-related morbidity healthcare disparities.

Language: Английский

Citations

0