Effects of Emerging Pollutant Mixtures: Assessing the Impact of Caffeine and Ionic Liquid on Cyanobacteria and Diatom Species

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: unknown, P. 138011 - 138011

Published: March 1, 2025

Language: Английский

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Metabolome and Its Mechanism Profiling in the Synergistic Toxic Effects Induced by Co-Exposure of Tenuazonic Acid and Patulin in Caco-2 Cells

Toxins, Journal Year: 2024, Volume and Issue: 16(7), P. 319 - 319

Published: July 15, 2024

Tenuazonic acid (TeA), usually found in cereals, fruits, vegetables, oil crops, and their products, was classified as one of the highest public health problems by EFSA early 2011, but it has still not been regulated legislation due to limited toxicological profile. Moreover, reported that coexistence TeA patulin (PAT) certain agricultural products; however, there are no available data about combined toxicity. Considering gastrointestinal tract is physiological barrier body, would be first target site at which exogenous substances interact with body. Thus, we assessed toxicity (cell viability, ROS, CAT, ATP) Caco-2 cells using mathematical modeling (Chou-Talalay) explored mechanisms non-targeted metabolomics molecular biology methods. It revealed co-exposure + PAT (12.5 μg/mL 0.5 μg/mL) can induce enhanced toxic effects more severe oxidative stress. Mechanistically, lipid amino metabolisms PI3K/AKT/FOXO signaling pathways were mainly involved PAT-induced synergistic effects. Our study only enriches scientific basis for development regulatory policies also provides potential targets treatment options alleviating toxicities.

Language: Английский

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Combined effect of zinc and cadmium ions on nitrification performance during the biological nitrogen removal of livestock breeding wastewater

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 13, 2024

Abstract Zinc and cadmium ions are usually found in livestock breeding wastewater, the mixed will have an impact on biological nitrogen removal. Nitrification performance plays important role In order to investigate combined effect of zinc nitrification reveal interactions between ions, three concentration ratios as well 18 different gradients were designed with direct equipartition ray dilution factor method. The pollutants removal was analyzed by nonlinear regression equation, concentration-addition model conducted probe into relationship performance. results showed that increased significantly increase reaction duration pollutant concentration, which indicated effects concentration-dependent time-dependent. suggested mainly antagonistic. However, interaction strengths, compared ratio R1, R2 R3 more antagonistic a greater

Language: Английский

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Predicting the occurrence of antagonism within ternary guanidine mixture pollutants based on the concentration ratio of components

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 913, P. 169380 - 169380

Published: Dec. 19, 2023

Language: Английский

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Combined effect of zinc and cadmium ions on nitrification performance during the biological nitrogen removal of simulated livestock breeding wastewater

Environmental Science and Pollution Research, Journal Year: 2024, Volume and Issue: 31(28), P. 41155 - 41166

Published: June 7, 2024

Language: Английский

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