Ceramics International, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 1, 2024
Language: Английский
Alexandria Engineering Journal, Journal Year: 2024, Volume and Issue: 88, P. 230 - 244
Published: Jan. 18, 2024
Infected wounds pose significant challenges in clinical settings due to the risk of complications and delayed healing wounds. The most common wound dressings are cotton balls gauze, yet these traditional have inherent shortcomings including low antibacterial properties, less oxygen permeation, mechanical moisture content essential for infected Herein, we fabricate polyvinyl alcohol/chitosan/pectin (PVA/CH/PEC) hydrogel loaded with green-synthesized nanometals, synthetic antibiotics treatment enhanced synergistic higher moisture, permeation content. silver nanoparticles (AgNPs), synthesized via sea buckthorn leaf extract, ciprofloxacin were incorporated bio-nanocomposite hydrogels. particle size AgNPs was found be range 15 42 nm. hydrogels confirm its biocompatible nature because reduction percentage hemolysis from 1.7% 1.4% cell viability exceeding 87% PVA/CH/PEC poly vinyl alcohol/chitosan/pectin–Silver/ (PVA/CH/PEC-Ag/cipro) membranes, respectively. Microscopic observation PVA/CH/PEC/Ag-Ciprofloxacin demonstrated last stages regeneration skin reformation towards normal as compared scaffold without ciprofloxacin. promoted advanced reformation, signifying potential a promising dressing material applications.
Language: Английский
Citations
3
Polymers and Polymer Composites, Journal Year: 2025, Volume and Issue: 33
Published: Jan. 1, 2025
Wound dressings used in medical applications serve as a protective barrier for wounds, creating an environment that promotes wound healing. The typical traditional often present challenges, including weak function and tendency to adhere wounds. Therefore, there is critical need develop advanced dressing with strong antibacterial properties can prevent the spread of infection accelerate healing process. To hydrogels properties, silver nanoparticles (AgNPs) derived from 1 mM AgNO 3 using green catalyst matcha tea extract ( camellia sinensis) were incorporated into chitosan alginate This was accomplished by mixing nitrate produce nanoparticles, which then added hydrogel crosslinkers. synthesized nanomaterials characterized UV-VIS spectroscopy, TEM, EDX, FTIR, SEM techniques. Their antimicrobial efficiency has been evaluated through inhibition zone assays, antibiofilm evaluation against P.aeruginosa, E. coli, S. aureus, C.albicans, A.niger, minimum inhibitory concentration (MIC). It found that, novel hydrogel, infused AgNPs, exhibited superior water absorption retention, ensuring moist while effectively absorbing substantial exudate. Additionally, demonstrated robust mechanical potent activity. study highlights exceptional newly developed natural polymer Ag anti-inflammatory action. Hence, silver-loaded proves be ideal material.
Language: Английский
Citations
0
Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 141741 - 141741
Published: Feb. 1, 2025
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 3937 - 3937
Published: April 1, 2024
In patients with autoimmune disorders such as rheumatoid arthritis (RA), delayed wound healing is often observed. Timely and effective a crucial determinant of patient's quality life, novel materials for skin repair, bioactive peptides, are continuously being studied developed. One peptide, AESIS-1, has been its well-established anti-rheumatoid properties. this study, we attempted to use the anti-RA material AESIS-1 therapeutic wound-healing agent based on disease-modifying antirheumatic drugs (DMARDs), which can help restore prompt healing. The efficacy in was assessed using full-thickness excision model diabetic mice; studying chronic repair. Initial observations revealed that mice treated exhibited significantly advanced repair compared control group. vitro studies increased migration activity human dermal fibroblasts (HDFs) without affecting proliferative activity. Moreover, HDF cell mediated by upregulating chemokine receptor expression, CXC 2 (CXCR2). upregulation CXCR2 through treatment enhanced chemotactic reactivity ligands, including motif ligand 8 (CXCL8). directly activates ERK p38 mitogen-activated protein kinase (MAPK) signaling cascades, regulate expression fibroblasts. Our results suggest peptide strong substance increases movement turning MAPK cascades.
Language: Английский
Citations
3
Catalysts, Journal Year: 2024, Volume and Issue: 14(6), P. 371 - 371
Published: June 10, 2024
Chitin and chitosan, abundant biopolymers derived from the shells of crustaceans cell walls fungi, have garnered considerable attention in pharmaceutical circles due to their biocompatibility, biodegradability, versatile properties. Deep eutectic solvents (DESs), emerging green composed mixtures hydrogen bond acceptors donors, offer promising avenues for enhancing solubility functionality chitin chitosan formulations. This review delves into potential utilizing DESs as highlighting efficiency dissolving these polymers, which facilitates production novel drug delivery systems, wound dressings, tissue engineering scaffolds, antimicrobial agents. The distinctive physicochemical properties DESs, including low toxicity, volatility, adaptable solvation power, enable customization chitosan-based materials meet specific requirements. Moreover, environmentally friendly nature aligns with growing demand sustainable eco-friendly processes manufacturing. revision underscores recent advances illustrating role evolving applications laying groundwork development innovative systems biomedical enhanced efficacy safety profiles.
Language: Английский
Citations
2
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 156888 - 156888
Published: Oct. 1, 2024
Language: Английский
Citations
2
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 282, P. 137352 - 137352
Published: Nov. 8, 2024
Language: Английский
Citations
2
Gels, Journal Year: 2024, Volume and Issue: 10(12), P. 835 - 835
Published: Dec. 18, 2024
Bacterial-infected skin wounds caused by trauma remain a significant challenge in modern medicine. Clinically, there is growing demand for wound dressings with exceptional antibacterial activity and robust regenerative properties. To address the need, this study proposes novel multifunctional dressing designed to combine efficient gas exchange, effective microbial barriers, precise drug delivery capabilities, thereby promoting cell proliferation accelerating healing. This work reports development of 3D-printed hydrogel scaffold incorporating flavanone (FLA)-loaded ZIF-8 nanoparticles (FLA@ZIF-8 NPs) within composite matrix κ-carrageenan (KC) konjac glucomannan (KGM). The forms stable dual-network structure through chelation KC potassium ions intermolecular hydrogen bonding between KGM. not only enhances mechanical stability but also improves its adaptability complex environments. In mildly acidic conditions, FLA@ZIF-8 NPs release Zn2+ controlled manner, providing sustained effects vivo studies using rat full-thickness infected model demonstrated that FLA@ZIF-8/KC@KGM significantly accelerated healing, showcasing superior performance treatment wounds.
Language: Английский
Citations
2
Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 100, P. 106138 - 106138
Published: Aug. 29, 2024
Language: Английский
Citations
1
Ceramics International, Journal Year: 2024, Volume and Issue: 50(18), P. 33656 - 33665
Published: June 14, 2024
Language: Английский
Citations
0