“The Effects of Oral Gestational Particulate Matter 10 Exposure: Insights into Neurodevelopmental Milestones, Inhibitory Control, Adult Sociability, and Object Recognition.”

NeuroToxicology, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Air pollutants have been associated with various neurodevelopmental disorders, several studies specifically linking Particulate Matter (PM) exposure to attentional and social deficits. This link is even more pronounced when occurs during the prenatal period, as it can disrupt normal brain development. However, while deficits extensively studied adolescence, their impact on adult behaviors remains largely unexplored. To investigate these effects, pregnant Wistar rats were exposed throughout gestation (GD1-GD21) PM10 at a dosage of 200μg/Kg/day diluted in PBS that was freely drunk. After birth, pups evaluated developmental milestones such weight progression, ocular opening, muscular strength. In adulthood, inhibitory control assessed using Five Choice Serial Reaction Time Task (5-CSRTT), behavior Three-Chambered Crawley's Test (3-CT), object recognition Novelty Object Recognition test (NOR). The results indicated higher birth poorer performance neuromuscular tests. no significant differences observed (5-CSRTT) or (3-CT). Interestingly, prenatally rodents showed heightened novelty responses NOR test. conclusion, gestational related milestones, including While does not behavior, influences later life.

Language: Английский

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Modulating Neurotoxic Effects of Prenatal Chlorpyrifos Exposure Through Probiotic and Vitamin D Gestational Supplementation: Unexpected Effects on Neurodevelopment and Sociability

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 4, 2024

Abstract Autism is a neurodevelopmental disorder characterized by impairments in sociability and communication. Prenatal exposure to Chlorpyrifos has been associated with autism-like behaviors preclinical models. Interest grown the gut-brain axis role of microbiota modulation through dietetic supplementation reduce this ASD-like phenotype. This study examines effects prenatal CPF Wistar Rats assesses potential gestational probiotic vitamin D mitigate these offspring. significantly impaired adolescence, did not reverse deficits. However, control animals, induced changes, including alterations metabolic status, pattern expression ASD-related genes, regulation oxytocin vasopressin receptors, GABAergic system brain. Additionally, accelerated overall development, increased ultrasonic vocalization emission modified typical responses social novelty. blocked most at both behavioral molecular levels. While block CPF-induced impairments, altered observed controls, possibly indicating shared mechanisms. These findings highlight need for further research into safety during pregnancy.

Language: Английский

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Research Progress on the Correlation Between Atmospheric Particulate Matter and Autism

Journal of Applied Toxicology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 19, 2024

ABSTRACT Autism spectrum disorder (ASD) is a neurodevelopmental caused by the interaction of genetic and complex environmental factors. The prevalence autism has dramatically increased in countries regions undergoing rapid industrialization urbanization. Recent studies have shown that particulate matter (PM) air pollution affects development neurons disrupts function nervous system, leading to behavioral cognitive problems increasing risk ASD. However, research on mechanism factors ASD still its infancy. On this basis, we conducted literature search analysis review epidemiological correlation between fine (PM 2.5 ) inhalable 10 signaling pathways pathogenic mechanisms PM synaptic injury neuroinflammation are presented, candidate gene SHANK 3 was reviewed. Additionally, different sites action particles animal models humans were highlighted, differences their effects pathogenesis explained. We summarized aetiology PM‐induced look forward future breakthroughs improved assessment methods, multidisciplinary alliances high‐tech innovations.

Language: Английский

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Spatio-Temporal Dynamics and Haze Agglomeration Analysis in the Beijing-Tianjin-Hebei Region: A WOA-LSTM Approach

Journal of Urban Development and Management, Journal Year: 2023, Volume and Issue: 2(3), P. 145 - 159

Published: Sept. 30, 2023

The intensification of industrial and urban growth has precipitated a significant increase in atmospheric pollutant emissions, thereby exacerbating air quality deterioration. This phenomenon is particularly pronounced within the Beijing-Tianjin-Hebei agglomeration, where haze events have manifested with increasing frequency. Prior investigations predominantly concentrated on temporal trends, often overlooking critical impact geographical factors development. research delves into spatio-temporal distribution traits region, employing Whale Optimization Algorithm-Long Short-Term Memory (WOA-LSTM) model. Findings indicate spatial concentration pollution region's southern sector. In terms distribution, Air Quality Index (AQI) demonstrates distinct seasonal fluctuations, highest levels recorded winter notably lower observed during summer. study's innovation lies development WOA-LSTM model, which not only predicts AQI - comprehensive index but also offers early warnings pertinent to public travel. By integrating extensive datasets applying advanced analytical techniques, study contributes significantly understanding complex interplay between dynamics distribution. underscores necessity for regional policies tailored specific spatiotemporal characteristics, aiding effective management mitigation strategies agglomerations.

Language: Английский

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