Nanozybiotics: Advancing Antimicrobial Strategies Through Biomimetic Mechanisms

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(33)

Published: June 14, 2024

Infectious diseases caused by bacterial, viral, and fungal pathogens present significant global health challenges. The rapid emergence of antimicrobial resistance exacerbates this issue, leading to a scenario where effective antibiotics are increasingly scarce. Traditional antibiotic development strategies proving inadequate against the swift evolution microbial resistance. Therefore, there is an urgent need develop novel with mechanisms distinct from those existing antibiotics. Nanozybiotics, which nanozyme-based antimicrobials, mimic catalytic action lysosomal enzymes in innate immune cells kill infectious pathogens. This review reinforces concept nanozymes provides comprehensive summary recent research advancements on potential candidates. Initially, nanozybiotics categorized based their activities, mimicking either oxidoreductase-like or hydrolase-like functions, thereby highlighting superior combating then discusses progress treating infections, confirming as translational nanozybiotic-based products, including hydrogels, nanorobots, sprays, bandages, masks, protective clothing, also considered. Finally, current challenges future prospects nanozybiotic-related products explored, emphasizing design capabilities for applications.

Language: Английский

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Ecotoxicity and trophic transfer of metallic nanomaterials in aquatic ecosystems

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 924, P. 171660 - 171660

Published: March 13, 2024

Language: Английский

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Co-exposure of butyl benzyl phthalate and TiO2 nanomaterials (anatase) in Metaphire guillelmi: Gut health implications by transcriptomics

Journal of Environmental Management, Journal Year: 2024, Volume and Issue: 354, P. 120429 - 120429

Published: Feb. 21, 2024

Language: Английский

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Toxicity of energetic nanomaterials assessed on L929 fibroblasts

Chemical Papers, Journal Year: 2024, Volume and Issue: 78(6), P. 3507 - 3514

Published: Feb. 15, 2024

Language: Английский

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In Silico Simulation of Daphnia magna Immobilization Exposed to Mixtures of TiO2 Nanoparticles with Inorganic Compounds

Journal of Composites Science, Journal Year: 2025, Volume and Issue: 9(1), P. 16 - 16

Published: Jan. 2, 2025

The development of models the physicochemical and biochemical behavior nanomaterials is useful for improving evaluation management this material. Quasi-SMILES technology makes it possible to quite successfully cope with kind modeling task, accounting various experimental conditions, where use other approaches difficult or even impossible. Here, we describe results using quasi-SMILES model toxicity mixtures titanium nano oxide inorganic substances towards Daphnia magna. approach based on stochastic process optimization correlation weights different codes used in quasi-SMILES. was carried out special statistical criteria predictive potential. It shown that built have best

Language: Английский

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Dilution Effect of Tempo-Oxidized Cellulose Nanofibers on Reproduction of Daphnia Magna

Published: Jan. 1, 2025

Language: Английский

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Soil enzyme activities and bacterial communities respond to co-exposure of butyl benzyl phthalate and TiO2 nanomaterials: Earthworm-mediated effects

Environmental Pollution, Journal Year: 2025, Volume and Issue: unknown, P. 126049 - 126049

Published: March 1, 2025

Language: Английский

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Dilution effect of TEMPO-oxidized cellulose nanofibers on reproduction of Daphnia magna

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 294, P. 118101 - 118101

Published: March 31, 2025

The expanding use of 2,2,6,6-tetramethylpiperidine-1-oxyl radical-oxidized cellulose nanofibers (TEMPO-CNFs) raises concerns about their environmental release and potential ecological impacts. Evaluating effects is critical for ensuring sustainable use. In this study, we aimed to assess the ecotoxicity TEMPO-CNFs on Daphnia magna reproduction explore mechanisms underlying observed effects. Reproductive toxicity was evaluated according Organisation Economic Co-operation Development test guideline, determining no effect concentration (NOEC) 10 % (EC10). Mechanistic insights were investigated through water chemistry analyses, a feeding inhibition test, gut evacuation experiment, 10-day life table experiments. NOEC EC10 12.5 mg/L 3.4 mg/L, respectively. Results supported dilution-effect hypothesis, indicating reduced availability essential food, such as Chlorella, driver toxicity. Gut experiments indicated that in D. individuals excreted within 24 h when they transferred CNF-free environment. results suggest are unlikely impact unless exposure continuous at high concentrations. These findings support environmentally application with controlled exposure.

Language: Английский

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Beneficial and toxicological impact of nanotechnology in agriculture as the basis for a regulatory framework

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 375 - 390

Published: Jan. 1, 2025

Language: Английский

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Electron-beam radiation-induced ultrafast synthesis of highly conjugated carbon quantum dots with excellent fluorescence intensity

Sustainable materials and technologies, Journal Year: 2025, Volume and Issue: unknown, P. e01448 - e01448

Published: May 1, 2025

Language: Английский

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